Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tasha R, Steel"'
Autor:
Lewis P. M. Green, Tasha R. Steel, Mie Riisom, Muhammad Hanif, Tilo Söhnel, Stephen M. F. Jamieson, L. James Wright, James D. Crowley, Christian G. Hartinger
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Multimetallic complexes have been shown in several examples to possess greater anticancer activity than their monometallic counterparts. The increased activity has been attributed to altered modes of action. We herein report the synthesis of a series
Externí odkaz:
https://doaj.org/article/a21f05c5e4db47739cd389b575891a47
Autor:
Matthew P. Sullivan, David C. Goldstone, Muhammad Hanif, Hugh H. Harris, Katja Hummitzsch, Jake W Andersen, Dianna Truong, Kelvin K. H. Tong, James H. Lovett, Tilo Söhnel, Christian G. Hartinger, Ingo Ott, Nils Metzler-Nolte, Tasha R. Steel, Stephen M. F. Jamieson, Andre Prause, Claire M. Weekley
Publikováno v:
Inorganic Chemistry. 59:3281-3289
Metal complexes provide a versatile platform to develop novel anticancer pharmacophores, and they form stable compounds with N-heterocyclic carbene (NHC) ligands, some of which have been shown to inhibit the cancer-related selenoenzyme thioredoxin re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e12beca9a85af62d04cca5037090f83
https://doi.org/10.1021/acs.inorgchem.9b03640
https://doi.org/10.1021/acs.inorgchem.9b03640
Autor:
Jonathan W. Astin, Muhammad Hanif, Stephen M. F. Jamieson, Shahida Parveen, Euphemia Leung, Tasha R. Steel, Christian G. Hartinger, Gayan Heruka De Zoysa, Annie Yang, Kelvin K. H. Tong, Sanam Movassaghi, David M. Goodman, Vijayalekshmi Sarojini, Tilo Söhnel
Publikováno v:
Chemical Communications. 55:12016-12019
Redox-modulating anticancer drugs allow the exploitation of altered redox biology observed in many cancer cells. We discovered dinuclear RhIII(Cp*) and IrIII(Cp*) complexes that have in vitro anticancer activity superior to cisplatin and the investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47201a98acb906af4753cd2959e512d
https://doi.org/10.1039/c9cc03822a
https://doi.org/10.1039/c9cc03822a
Autor:
Corinna Schattschneider, Haleh H. Haeri, Dariush Hinderberger, Karolina Bossad-Ahmad, Mie Riisom, Christian G. Hartinger, Stephen M. F. Jamieson, Alexander Langhans, Jannis Barrera, Wojciech Bal, Nora Kulak, Matthias Stein, Tasha R. Steel, Julian Heinrich, Vinja Hergl
Publikováno v:
Chemistry – A European Journal
Redox-active Cu(II) complexes are able to form reactive oxygen species (ROS) in the presence of oxygen and reducing agents. Recently, Faller et al. reported that ROS generation by Cu(II) ATCUN complexes is not as high as assumed for decades. High com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2836cb910089a2809a1c24d88e8d3192
https://doi.org/10.1002/chem.202102601
https://doi.org/10.1002/chem.202102601
Autor:
Tasha R. Steel, Christian G. Hartinger
Publikováno v:
Metallomics : integrated biometal science. 12(11)
Proteomics has played an important role in elucidating the fundamental processes occuring in living cells. Translating these methods to metallodrug research (‘metalloproteomics’) has provided a means for molecular target identification of metal-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b451ac8f1ed1a2e3e87e038e4e6e5429
https://pubmed.ncbi.nlm.nih.gov/33063808
https://pubmed.ncbi.nlm.nih.gov/33063808
Autor:
Dianna, Truong, Matthew P, Sullivan, Kelvin K H, Tong, Tasha R, Steel, Andre, Prause, James H, Lovett, Jake W, Andersen, Stephen M F, Jamieson, Hugh H, Harris, Ingo, Ott, Claire M, Weekley, Katja, Hummitzsch, Tilo, Söhnel, Muhammad, Hanif, Nils, Metzler-Nolte, David C, Goldstone, Christian G, Hartinger
Publikováno v:
Inorganic chemistry. 59(5)
Metal complexes provide a versatile platform to develop novel anticancer pharmacophores, and they form stable compounds with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a4b4b57fbc1164427543707d662f4fb
https://pubmed.ncbi.nlm.nih.gov/32073260
https://pubmed.ncbi.nlm.nih.gov/32073260
Autor:
Saawan Kumar, Muhammad Hanif, Tasha R. Steel, Christian G. Hartinger, Anna Wieczorek-Błauż, Fearghal P. Walsh, Matthew P. Sullivan, David M. Goodman, William D.J. Tremlett
Publikováno v:
Coordination Chemistry Reviews. 445:213950
The small molecule anticancer agent cisplatin and its Pt(II) analogs carboplatin and oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural simplicity, side effects and disadvantages, they are cornerstones of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::720438229dcf9e827537aed5d4825529
https://doi.org/10.1016/j.ccr.2021.213950
https://doi.org/10.1016/j.ccr.2021.213950
Autor:
Anna Wieczorek-Błauż, Muhammad Hanif, Christian G. Hartinger, Tasha R. Steel, Fearghal P. Walsh
Publikováno v:
Coordination Chemistry Reviews. 439:213890
Metallodrugs have a central role in the treatment and diagnosis of diseases. To overcome potential toxicity and equip metal-based anticancer agents with biological activity, the choice of the ligands coordinated to the metal center is essential. A re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04c42fc450387d5e92b4a810733daa5b
https://doi.org/10.1016/j.ccr.2021.213890
https://doi.org/10.1016/j.ccr.2021.213890
Autor:
Kelvin K. H. Tong, Christian G. Hartinger, Stephen M. F. Jamieson, Muhammad Hanif, James D. Crowley, L. James Wright, Tasha R. Steel, Tilo Söhnel
Publikováno v:
Inorganica Chimica Acta. 518:120220
In some instances, multimetallic complexes have shown higher anticancer activity than mononuclear analogues, possibly by interacting with target molecules through a different binding mode. Therefore, a series of novel bis-pyridylimine-based homodinuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce2dd7d1703cdc626645bf660ecb64c5
https://doi.org/10.1016/j.ica.2020.120220
https://doi.org/10.1016/j.ica.2020.120220
Autor:
Sanam Movassaghi, William D.J. Tremlett, Tasha R. Steel, Tilo Söhnel, Stephen M. F. Jamieson, Christian G. Hartinger, Muhammad Hanif, Kelvin K. H. Tong
Publikováno v:
Journal of Inorganic Biochemistry. 199:110768
Organometallic compounds based on bioactive ligand systems have shown promising antiproliferative properties. The use of 8-hydroxyquinoline and its derivatives as bioactive ligands resulted in organometallic complexes with potent anticancer activity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95151c5d6b66d0a6d7b8442ebef48f8
https://doi.org/10.1016/j.jinorgbio.2019.110768
https://doi.org/10.1016/j.jinorgbio.2019.110768