Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Tasha Morrison"'
Autor:
Kim Vanuytsel, Taylor Matte, Amy Leung, Zaw Htut Naing, Tasha Morrison, David H.K. Chui, Martin H. Steinberg, George J. Murphy
Publikováno v:
Blood Advances, Vol 2, Iss 15, Pp 1998-2011 (2018)
Abstract: Robust β-globin expression in erythroid cells derived from induced pluripotent stem cells (iPSCs) increases the resolution with which red blood cell disorders such as sickle cell disease and β thalassemia can be modeled in vitro. To bette
Externí odkaz:
https://doaj.org/article/90f65c6905b545d187d63ae96104ade0
Autor:
David H.K. Chui, George J. Murphy, Tasha Morrison, Zaw Htut Naing, Taylor Matte, Kim Vanuytsel, Martin H. Steinberg, Amy Leung
Publikováno v:
Blood advances. 2(15)
Robust β-globin expression in erythroid cells derived from induced pluripotent stem cells (iPSCs) increases the resolution with which red blood cell disorders such as sickle cell disease and β thalassemia can be modeled in vitro. To better quantify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c77b855632f2e0df405f49b8295922e
https://pubmed.ncbi.nlm.nih.gov/30108108
https://pubmed.ncbi.nlm.nih.gov/30108108
Autor:
Shuaiying Cui, George J. Murphy, David H.K. Chui, Ibifiri Wilcox, Tasha Morrison, Ryo Kurita, Hong-Yuan Luo, Yukio Nakamura, John J. Farrell, Martin H. Steinberg
Publikováno v:
Blood cells, moleculesdiseases. 69
The HBS1L-MYB intergenic region (chr6q23) regulates erythroid cell proliferation, maturation, and fetal hemoglobin (HbF) expression. An enhancer element within this locus, highlighted by a 3-bp deletion polymorphism (rs66650371), is known to interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ea7efa5057cfc08de2dc2be4ce2ba8
https://pubmed.ncbi.nlm.nih.gov/29227829
https://pubmed.ncbi.nlm.nih.gov/29227829
Autor:
George J. Murphy, Elizabeth Stanford Zulick, Nicholas Skvir, Zaw Htut Naing, Amy Leung, Kim Vanuytsel, Martin H. Steinberg, Tasha Morrison, David H. Sherr, Yan Dai, Zhongyan Wang, David H.K. Chui
Publikováno v:
Stem Cells (Dayton, Ohio)
Induced pluripotent stem cells (iPSCs) stand to revolutionize the way we study human development, model disease, and eventually, treat patients. However, these cell sources produce progeny that retain embryonic and/or fetal characteristics. The failu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d863691064f81e2773e903d61c3bdf26
https://pubmed.ncbi.nlm.nih.gov/29569827
https://pubmed.ncbi.nlm.nih.gov/29569827
Autor:
Elizabeth P. Henske, Yanan Guo, Jing Li, Carmen Priolo, Neil Auricchio, Po-Shun Lee, Chenggang Li, Andrey A. Parkhitko, Anna Planaguma, Kai-Feng Xu, Yang Sun, David J. Kwiatkowski, Chin-Lee Wu, Xiaoxiao Gu, Bruce D. Levy, John Blenis, Erik Zhang, Elliot Israel, Tasha Morrison, Shamsah Kazani, Jane J. Yu, Alfredo Csibi
Publikováno v:
The Journal of Experimental Medicine
Estradiol enhances COX-2 expression and prostaglandin biosynthesis in TSC2-deficient cells via a rapamycin-insensitive, mTORC2-dependent mechanism.
Lymphangioleiomyomatosis (LAM) is a progressive neoplastic disorder that leads to lung destructio
Lymphangioleiomyomatosis (LAM) is a progressive neoplastic disorder that leads to lung destructio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0fec8e6f6829369241fd66e92a7c29
https://doi.org/10.1084/jem.20131080
https://doi.org/10.1084/jem.20131080
Autor:
Jane J. Yu, Erik Zhang, Yuanguang Chen, Chenggang Li, Jing Li, Na Li, John Blenis, Jiang Wang, Tasha Morrison, Julia Sun, Yi Zhang, Mauricio J. Reginato, Kouhei Masuda, Xiangke Li, Elizabeth P. Henske, Nagla Abdel Karim, Yang Sun, Xiaolei Liu
Publikováno v:
JCI insight. 1(19)
Lymphangioleiomyomatosis (LAM) is a progressive lung disease that primarily affects young women. Genetic evidence suggests that LAM cells bearing TSC2 mutations migrate to the lungs, proliferate, and cause cystic remodeling. The female predominance i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7f0e31e8262da168d9f08e8ebbb622
https://pubmed.ncbi.nlm.nih.gov/27882343
https://pubmed.ncbi.nlm.nih.gov/27882343
Autor:
J. Julia Wu, Neil Auricchio, Toren Finkel, Andrey A. Parkhitko, Jane J. Yu, Elizabeth P. Henske, Magdalena Karbowniczek, Faina Myachina, Khadijah M. Hindi, Tasha Morrison, David J. Kwiatkowski
Publikováno v:
Proceedings of the National Academy of Sciences. 108:12455-12460
Tuberous sclerosis complex (TSC) is a tumor suppressor syndrome characterized by benign tumors in multiple organs, including the brain and kidney. TSC-associated tumors exhibit hyperactivation of mammalian target of rapamycin complex 1 (mTORC1), a di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db10d879bdb7710f52085260c84ad474
https://doi.org/10.1073/pnas.1104361108
https://doi.org/10.1073/pnas.1104361108
Autor:
Jane J. Yu, Fabrice Roegiers, Rachel Squillace, Emmanuelle Nicolas, Tasha Morrison, Diana Zitserman, Magdalena Karbowniczek, Elizabeth P. Henske, Tiffiney R. Hartman, Damir Khabibullin
Publikováno v:
Journal of Clinical Investigation. 120:93-102
Mutations in either of the genes encoding the tuberous sclerosis complex (TSC), TSC1 and TSC2, result in a multisystem tumor disorder characterized by lesions with unusual lineage expression patterns. How these unusual cell-fate determination pattern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59879c8cc8b4b1bef4049befa58071c
https://doi.org/10.1172/jci40221
https://doi.org/10.1172/jci40221
Publikováno v:
Journal of Investigative Dermatology. 128:980-987
The objective of this study was to determine whether activation of the kinase mammalian target of rapamycin (mTOR) is associated with human melanoma. We found moderate or strong hyperphosphorylation of ribosomal protein S6 in 78/107 melanomas (73%).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58327985638688058be86ab6e7063d18
https://doi.org/10.1038/sj.jid.5701074
https://doi.org/10.1038/sj.jid.5701074
Autor:
Yang Sun, Xiaobo Zhou, Ana Pereira, Chenggang Li, Kathleen J. Haley, Li Xiong, Taotao Lao, Erik Zhang, Jane J. Yu, Tasha Morrison
Publikováno v:
Hormonescancer. 5(5)
Lymphangioleiomyomatosis (LAM) is a female-predominant lung disease that can lead to respiratory failure. LAM cells typically have inactivating tuberous sclerosis 2 (TSC2) mutations, leading to mTORC1 hyperactivation. The gender specificity of LAM su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1342a2af2fd507ac23f563fad35063d6
https://pubmed.ncbi.nlm.nih.gov/25069840
https://pubmed.ncbi.nlm.nih.gov/25069840