Focused CRISPR-Cas9 genetic screening reveals USO1 as a vulnerability in B-cell acute lymphoblastic leukemia

Autor: Amit Kumar Jaiswal, Hellen Truong, Tiffany M. Tran, Tasha L. Lin, David Casero, Michael O. Alberti, Dinesh S. Rao

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Post-transcriptional gene regulation, including that by RNA binding proteins (RBPs), has recently been described as an important mechanism in cancer. We had previously identified a set of RBPs that were highly dysregulated in B-cell acute ly

Externí odkaz: https://doaj.org/article/21414bf1581e42608d925e918106ab1e

The RNA-binding protein IGF2BP3 is critical for MLL-AF4-mediated leukemogenesis

Autor: Oscar Silva, J. King, May Paing, Julia Philipp, Dinesh S. Rao, Tasha L. Lin, Tiffany M. Tran, Jaspal Bassi, Sol Katzman, Jeremy R. Sanford, Amit Kumar Jaiswal, Jolene M. Draper, Neha Nibber, Jayanth Kumar Palanichamy

Publikováno v: Leukemia, vol 36, iss 1
Leukemia

Despite recent advances in therapeutic approaches, patients with MLL-rearranged leukemia still have poor outcomes. Here, we find that the RNA-binding protein IGF2BP3, which is overexpressed in MLL-translocated leukemia, strongly amplifies MLL-Af4-med

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5597ab10bcdee8f0c9f1537a25fd07
https://escholarship.org/uc/item/5wr144fv

IGF2BP3 as a Prognostic Biomarker in Well-Differentiated/Dedifferentiated Liposarcoma.

Autor: Klingbeil, Kyle D.^1,2,3 (AUTHOR) chrisfrias@mednet.ucla.edu, Tang, Jack Pengfei⁴ (AUTHOR), Graham, Danielle S.^1,2 (AUTHOR), Lofftus, Serena Y.¹ (AUTHOR), Jaiswal, Amit Kumar⁵ (AUTHOR), Lin, Tasha L.⁶ (AUTHOR), Frias, Chris¹ (AUTHOR), Chen, Lucia Y.⁷ (AUTHOR), Nakasaki, Manando⁵ (AUTHOR), Dry, Sarah M.^2,5 (AUTHOR), Crompton, Joseph G.^1,2 (AUTHOR), Eilber, Fritz C.^1,2 (AUTHOR), Rao, Dinesh S.^2,5,8 (AUTHOR), Kalbasi, Anusha⁹ (AUTHOR) akalbasi@stanford.edu, Kadera, Brian E.^1,2 (AUTHOR) akalbasi@stanford.edu

Publikováno v: Cancers. Sep2023, Vol. 15 Issue 18, p4489. 14p.

The RNA-binding protein IGF2BP3 is critical for MLL-AF4-mediated leukemogenesis.

Autor: Tran TM; Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA.; Molecular, Cellular, and Integrative Physiology Interdepartmental Ph.D. Program, UCLA, Los Angeles, CA, 90095, USA., Philipp J; Department of Molecular, Cellular and Developmental Biology, UCSC, Santa Cruz, CA, 95064, USA., Bassi JS; Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA., Nibber N; Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA., Draper JM; Department of Molecular, Cellular and Developmental Biology, UCSC, Santa Cruz, CA, 95064, USA., Lin TL; Division of Hematology/Oncology, Department of Medicine, UCLA, Los Angeles, CA, 90095, USA.; Molecular Biology Interdepartmental Doctoral Program, UCLA, Los Angeles, CA, 90095, USA., Palanichamy JK; Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA.; Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, 110029, India., Jaiswal AK; Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA., Silva O; Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA., Paing M; Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA., King J; Division of Rheumatology, Department of Medicine, UCLA, Los Angeles, CA, 90095, USA., Katzman S; UCSC Genomics Institute, Santa Cruz, CA, 95064, USA., Sanford JR; Department of Molecular, Cellular and Developmental Biology, UCSC, Santa Cruz, CA, 95064, USA., Rao DS; Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA. DRao@mednet.ucla.edu.; Molecular, Cellular, and Integrative Physiology Interdepartmental Ph.D. Program, UCLA, Los Angeles, CA, 90095, USA. DRao@mednet.ucla.edu.; Jonsson Comprehensive Cancer Center (JCCC), UCLA, Los Angeles, CA, 90095, USA. DRao@mednet.ucla.edu.; Broad Stem Cell Research Center, UCLA, Los Angeles, CA, 90095, USA. DRao@mednet.ucla.edu.

Publikováno v: Leukemia [Leukemia] 2022 Jan; Vol. 36 (1), pp. 68-79. Date of Electronic Publication: 2021 Jul 29.