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Akademický článek

Leveraging the microbiome to understand clinical heterogeneity in depression: findings from the T-RAD study

Autor: Cherise R. Chin Fatt, Sarah Asbury, Manish K. Jha, Abu Minhajuddin, Sangita Sethuram, Taryn Mayes, Sidney H. Kennedy, Jane A. Foster, Madhukar H. Trivedi

Publikováno v: Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract Alterations in the gut microbiome have been linked to a variety of mental illnesses including anxiety and depression. This study utilized advanced bioinformatics tools that integrated both the compositional and community nature of gut microb

Externí odkaz: https://doaj.org/article/733ffc6714da42598571f4ed35ce0279

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Akademický článek

Multi-omics driven predictions of response to acute phase combination antidepressant therapy: a machine learning approach with cross-trial replication

Autor: Jeremiah B. Joyce, Caroline W. Grant, Duan Liu, Siamak MahmoudianDehkordi, Rima Kaddurah-Daouk, Michelle Skime, Joanna Biernacka, Mark A. Frye, Taryn Mayes, Thomas Carmody, Paul E. Croarkin, Liewei Wang, Richard Weinshilboum, William V. Bobo, Madhukar H. Trivedi, Arjun P. Athreya

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Combination antidepressant pharmacotherapies are frequently used to treat major depressive disorder (MDD). However, there is no evidence that machine learning approaches combining multi-omics measures (e.g., genomics and plasma metabolomics)

Externí odkaz: https://doaj.org/article/bf2ec854954a47dc9cf4c2ef7c12b746

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Akademický článek

Immune characterization of suicidal behavior in female adolescents

Autor: Cherise R. Chin Fatt, J. David Farrar, Manish K. Jha, Abu Minhajuddin, Taryn Mayes, Jane A. Foster, Madhukar H. Trivedi

Publikováno v: Brain, Behavior, & Immunity - Health, Vol 25, Iss , Pp 100499- (2022)

Background: To address the need to identify potential markers of suicide behavior for adolescents (ages 12–18 years), mass cytometry was used to explore the cellular mechanisms that may underpin immune dysregulation in adolescents with recent suici

Externí odkaz: https://doaj.org/article/98d3e3e73c634230a0a5a93e8dd93093

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Akademický článek

Network science approach elucidates integrative genomic-metabolomic signature of antidepressant response and lifetime history of attempted suicide in adults with major depressive disorder

Autor: Caroline W. Grant, Angelina R. Wilton, Rima Kaddurah-Daouk, Michelle Skime, Joanna Biernacka, Taryn Mayes, Thomas Carmody, Liewei Wang, Konstantinos Lazaridis, Richard Weinshilboum, William V. Bobo, Madhukar H. Trivedi, Paul E. Croarkin, Arjun P. Athreya

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Background: Individuals with major depressive disorder (MDD) and a lifetime history of attempted suicide demonstrate lower antidepressant response rates than those without a prior suicide attempt. Identifying biomarkers of antidepressant response and

Externí odkaz: https://doaj.org/article/610d982fbf6b413188abb5c457460212

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The impact of age on antidepressant response: A mega-analysis of individuals with major depressive disorder

Autor: Jeffrey R. Strawn, Jeffrey A. Mills, Vikram Suresh, Taryn Mayes, Melanie T. Gentry, Madhukar Trivedi, Paul E. Croarkin

Publikováno v: Journal of Psychiatric Research. 159:266-273

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4a0f2622eae96bea09f28dfc285ffd0
https://doi.org/10.1016/j.jpsychires.2023.01.043

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Data driven clusters derived from resting state functional connectivity: Findings from the EMBARC study

Autor: Cherise R. Chin Fatt, Abu Minhajuddin, Manish K. Jha, Taryn Mayes, A. John Rush, Madhukar H. Trivedi

Publikováno v: Journal of Psychiatric Research. 158:150-156

To address the clinical heterogeneity of Major Depressive Disorder (MDD), this investigation determined whether resting state functional magnetic resonance imaging (fMRI) could be deployed to identify circuit based homogeneous subgroups, and whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7ac4e0e865ee7b5d0341498c45444d
https://doi.org/10.1016/j.jpsychires.2022.12.002

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