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pro vyhledávání: '"Taryn Loomis"'
Matrix stiffness and architecture drive fibro-adipogenic progenitors’ activation into myofibroblasts
Autor:
Taryn Loomis, Lin-Ya Hu, Ross P. Wohlgemuth, Rosemary R. Chellakudam, Pooja D. Muralidharan, Lucas R. Smith
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Fibro-adipogenic progenitors (FAPs) are essential in supporting regeneration in skeletal muscle, but in muscle pathologies FAPs the are main source of excess extracellular matrix (ECM) resulting in fibrosis. Fibrotic ECM has altered mechanic
Externí odkaz:
https://doaj.org/article/d4c89bcf1aff489aace0172dfaa34bfa
Autor:
Marissa Gionet-Gonzales, Cassidy Jane Mileti, Sarah Ahmad, J. Kent Leach, Taryn Loomis, Lin-Ya Hu, Ross P. Wohlgemuth, Sarah E. Brashear, Lucas R. Smith, Rosemary R Chellakudam
Publikováno v:
Am J Physiol Cell Physiol
Muscle stem cells (MuSCs) are essential for the robust regenerative capacity of skeletal muscle. However, in fibrotic environments marked by abundant collagen and altered collagen organization, the regenerative capability of MuSCs is diminished. MuSC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8fbb4ba73f09791c69d13f9e168901
https://pubmed.ncbi.nlm.nih.gov/34191625
https://pubmed.ncbi.nlm.nih.gov/34191625