Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Taryn E Gillies"'
Autor:
Taryn E Gillies, Michael Pargett, Jillian M Silva, Carolyn K Teragawa, Frank McCormick, John G Albeck
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 10, Pp 1-19 (2020)
Abstract Activating mutations in RAS are present in ~ 30% of human tumors, and the resulting aberrations in ERK/MAPK signaling play a central role in oncogenesis. However, the form of these signaling changes is uncertain, with activating RAS mutants
Externí odkaz:
https://doaj.org/article/804bdc66e1774d43b932492177689289
Autor:
Yin P Hung, Carolyn Teragawa, Nont Kosaisawe, Taryn E Gillies, Michael Pargett, Marta Minguet, Kevin Distor, Briana L Rocha-Gregg, Jonathan L Coloff, Mark A Keibler, Gregory Stephanopoulos, Gary Yellen, Joan S Brugge, John G Albeck
Publikováno v:
eLife, Vol 6 (2017)
Cells use multiple feedback controls to regulate metabolism in response to nutrient and signaling inputs. However, feedback creates the potential for unstable network responses. We examined how concentrations of key metabolites and signaling pathways
Externí odkaz:
https://doaj.org/article/f8f04aa15ba940f9b5b72b1ccab92464
Publikováno v:
Cell Syst
Summary Quantitative systems biology, in which predictive mathematical models are constructed to guide the design of experiments and predict experimental outcomes, is at an exciting transition point, where the foundational scientific principles are b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543149b13db699945d1c8c1dc2ac21c4
https://europepmc.org/articles/PMC8217727/
https://europepmc.org/articles/PMC8217727/
Autor:
Jarrett D. Egertson, Cassandra Stawicki, Taryn E. Gillies, James H. Joly, Noah Steiner, Kevin Cardenas, Jonathan B. Leano, Kevin Chen, Sophie Watts, Hunter B. Boyce, Dan DiPasquo, Alana Killeen, Vadim Lobanov, Greg Kapp, Sujal Patel, Parag Mallick
Publikováno v:
Cancer Research. 82:LB225-LB225
Protein Identification by Short-epitope Mapping (PrISM) is a novel proteomics method with the goal of comprehensive proteome quantification at single-molecule sensitivity. In this work, we present computational modeling demonstrating the feasibility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8192fc0699725988348163484613469
https://doi.org/10.1158/1538-7445.am2022-lb225
https://doi.org/10.1158/1538-7445.am2022-lb225
Autor:
Frank McCormick, John G. Albeck, Taryn E. Gillies, Carolyn Teragawa, Jillian M. Silva, Michael Pargett
Publikováno v:
Molecular Systems Biology
Molecular Systems Biology, Vol 16, Iss 10, Pp n/a-n/a (2020)
Molecular systems biology, vol 16, iss 10
Molecular Systems Biology, Vol 16, Iss 10, Pp n/a-n/a (2020)
Molecular systems biology, vol 16, iss 10
Activating mutations in RAS are present in ~ 30% of human tumors, and the resulting aberrations in ERK/MAPK signaling play a central role in oncogenesis. However, the form of these signaling changes is uncertain, with activating RAS mutants linked to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d0710560595328af36d85162776db5
https://pubmed.ncbi.nlm.nih.gov/33073539
https://pubmed.ncbi.nlm.nih.gov/33073539
Publikováno v:
The Journal of biological chemistry, vol 294, iss 47
J Biol Chem
J Biol Chem
The association of plasma membrane (PM)-localized voltage-gated potassium (Kv2) channels with endoplasmic reticulum (ER)-localized vesicle-associated membrane protein-associated proteins VAPA and VAPB defines ER–PM junctions in mammalian brain neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44617fa67c3d7f670a60b1fa0085831a
https://escholarship.org/uc/item/07k8f443
https://escholarship.org/uc/item/07k8f443
Autor:
Michael Pargett, Alexander E. Davies, Gerald Quon, Savannah J. Tobin, Celina E. Juliano, Stefan Siebert, Taryn E. Gillies, Mina J. Bissell, Yongin Choi, Vaibhav Murthy, Abhineet R. Ram, John G. Albeck
Publikováno v:
Cell Syst
Intratumoral heterogeneity is associated with aggressive tumor behavior, therapy resistance, and poor patient outcomes. Such heterogeneity is thought to be dynamic, shifting over periods of minutes to hours in response to signaling inputs from the tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a727a2eaebb806edf4db0aa7179275c7
https://doi.org/10.1016/j.cels.2020.07.004
https://doi.org/10.1016/j.cels.2020.07.004
Autor:
Peter D. Karp, Inbal Maayan, Gwanggyu Sun, Sajia Akhter, Taryn E. Gillies, Daniel Weaver, Heejo Choi, Jerry H. Morrison, Samuel R. Bray, Ingrid M. Keseler, Morgan L. Paull, Ryan K. Spangler, Travis A. Ahn-Horst, Markus W. Covert, Nicholas A. Ruggero, Mialy M. DeFelice, John C. Mason, Javier Carrera, Derek N. Macklin, Keara Michelle Lane, Eran Agmon
Publikováno v:
Science. 369:eaav3751
The extensive heterogeneity of biological data poses challenges to analysis and interpretation. Construction of a large-scale mechanistic model of Escherichia coli enabled us to integrate and cross-evaluate a massive, heterogeneous dataset based on m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94b08b6985d35dcd7c31c99e05c62ffb
https://doi.org/10.1126/science.aav3751
https://doi.org/10.1126/science.aav3751
Autor:
Savannah J Tobin, Abhineet R. Ram, Gerald Quon, Alexander E. Davies, Taryn E. Gillies, Mina J. Bissell, Celina E. Juliano, Stefan Siebert, John G. Albeck, Michael Pargett
The EGFR/Ras/ERK signalling pathway is a driver of cancer cell proliferation and metastasis in tumours that exhibit high cell-to-cell heterogeneity. While the signalling activity of this pathway is frequently amplified in tumours, it is not understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e5059074ff6ff964795db4a3753683
https://doi.org/10.1101/466656
https://doi.org/10.1101/466656
Autor:
Derek N, Macklin, Travis A, Ahn-Horst, Heejo, Choi, Nicholas A, Ruggero, Javier, Carrera, John C, Mason, Gwanggyu, Sun, Eran, Agmon, Mialy M, DeFelice, Inbal, Maayan, Keara, Lane, Ryan K, Spangler, Taryn E, Gillies, Morgan L, Paull, Sajia, Akhter, Samuel R, Bray, Daniel S, Weaver, Ingrid M, Keseler, Peter D, Karp, Jerry H, Morrison, Markus W, Covert
Publikováno v:
Science (New York, N.Y.). 369(6502)
The extensive heterogeneity of biological data poses challenges to analysis and interpretation. Construction of a large-scale mechanistic model of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9276b425197d6724fbd306f575e1a3a3
https://pubmed.ncbi.nlm.nih.gov/32994565
https://pubmed.ncbi.nlm.nih.gov/32994565