Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tarun V. Kamath"'
Autor:
Simon Dujardin, Analiese Fernandes, Riley Bannon, Caitlin Commins, Mark De Los Santos, Tarun V. Kamath, Mansuo Hayashi, Bradley T. Hyman
Publikováno v:
Brain Communications. 4
Progressive cognitive decline in Alzheimer’s disease correlates closely with the spread of tau protein aggregation across neural networks of the cortical mantle. We tested the hypothesis that heritable factors may influence the rate of propagation
Autor:
Caitlin Commins, Bradley T. Hyman, Naomi Klickstein, Matthew P. Frosch, Simon Dujardin, Tarun V. Kamath, Analiese R. Fernandes, Derek H. Oakley
Publikováno v:
Brain Communications
The accumulation of tau aggregates throughout the human brain is the hallmark of a number of neurodegenerative conditions classified as tauopathies. Increasing evidence shows that tau aggregation occurs in a ‘prion-like’ manner, in which a small
Autor:
Bradley T. Hyman, Tarun V. Kamath, Simon Dujardin, Derek H. Oakley, Caitlin Commins, Naomi Klickstein
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Riley N. Bannon, Tarun V. Kamath, Simon Dujardin, Bradley T. Hyman, Analiese R. Fernandes, Mark B. De Los Santos, Caitlin Commins
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Miwei Hu, Marta Perez-Rando, Bradley T. Hyman, Ashley B. Robbins, Analiese R. Fernandes, Tarun V. Kamath, Rachel E. Bennett, Simon Dujardin
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)
Microangiopathy, including proliferation of small diameter capillaries, increasing vessel tortuosity, and increased capillary blockage by leukocytes, was previously observed in the aged rTg4510 mouse model. Similar gene expression changes related to
Autor:
Ryan C. Clark, Bradley T. Hyman, Simon Dujardin, Benjamin D. Moore, Patrick M. Dooley, Mark B. De Los Santos, Caitlin Commins, Matthew E. Kennedy, Tarun V. Kamath, Dinorah Jean-Gilles
Publikováno v:
Alzheimer's & Dementia. 15
Autor:
Judith A. Steen, Dinorah Jean-Gilles, Pieter Beerepoot, Naomi Klickstein, Bradley T. Hyman, Mark B. De Los Santos, Tarun V. Kamath, Renee Moore, Arthur Viode, Aurélien Lathuilière, Lori B. Chibnik, Matthew P. Frosch, Ryan C. Clark, Derek H. Oakley, Alberto Serrano-Pozo, Benjamin D. Moore, Fiona Elwood, Rudolph E. Tanzi, Diana L. Corjuc, Simon Dujardin, Analiese R. Fernandes, Matthew E. Kennedy, Patrick M. Dooley, Bianca T. Corjuc, Kristina Mullin, Caitlin Commins, Kevin Atchison
Publikováno v:
Nat Med
Nature medicine, Vol. 26, No 8 (2020) pp. 1256-1263
Nature medicine, Vol. 26, No 8 (2020) pp. 1256-1263
Alzheimer's disease (AD) causes unrelenting, progressive cognitive impairments, but its course is heterogeneous, with a broad range of rates of cognitive decline1. The spread of tau aggregates (neurofibrillary tangles) across the cerebral cortex para
Autor:
Lori B. Chibnik, Benjamin D. Moore, Arthur Viode, Fiona Elwood, Tarun V. Kamath, Renee Moore, Patrick M. Dooley, Derek H. Oakley, Dinorah Jean-Gilles, Pieter Beerepoot, Alberto Serrano-Pozo, Diana L. Corjuc, Naomi Klickstein, Bradley T. Hyman, Kevin Atchison, Mark B. De Los Santos, Matthew P. Frosch, Aurélien Lathuilière, Judith A. Steen, Kristina Mullin, Analiese R. Fernandes, Matthew E. Kennedy, Caitlin Commins, Rudolph E. Tanzi, Simon Dujardin, Ryan C. Clark, Bianca T. Corjuc
Publikováno v:
Nature Medicine. 27:356-356
Autor:
Bradley T. Hyman, Naomi Klickstein, Marc Aurel Busche, George A. Carlson, Tarun V. Kamath, Julia Schiantarelli, Israel Nelken, Susanne Wegmann, Simon Dujardin, Caitlin Commins
Publikováno v:
Nature reviews / Neuroscience 22(1), 57-64 (2018). doi:10.1038/s41593-018-0289-8
The coexistence of amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the neocortex is linked to neural system failure and cognitive decline in Alzheimer’s disease. However, the underlying neuronal mechanisms are unknown. By employing in v
Autor:
Zhanyun Fan, Tarun V. Kamath, Anthony A. Hyman, Charles R. Vanderburg, J. Paul Taylor, Bahareh Eftekharzadeh, Amandine Molliex, Bradley T. Hyman, Katarzyna Marta Zoltowska, Katharina Tepper, Rachel E. Bennett, Allyson D. Roe, Pawel R. Laskowski, Susanne Wegmann, Amayra Hernández-Vega, Daniel J. Müller, Caitlin Commins, Eckhard Mandelkow, Simon Dujardin, Danny MacKenzie
Publikováno v:
EMBO Journal
The EMBO Journal
The EMBO journal 37(7), e98049 (2018). doi:10.15252/embj.201798049
The EMBO Journal
The EMBO journal 37(7), e98049 (2018). doi:10.15252/embj.201798049
The transition between soluble intrinsically disordered tau protein and aggregated tau in neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau species can undergo liquid–liquid phase separation (LLPS) under c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9167a871aa08aef02aee28352f25acf4
https://hdl.handle.net/21.11116/0000-0003-53A6-421.11116/0000-0003-53A8-2
https://hdl.handle.net/21.11116/0000-0003-53A6-421.11116/0000-0003-53A8-2