Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Tarun N. Bhatia"'
Autor:
Silvia Radenkovic, Rohit Budhraja, Teun Klein-Gunnewiek, Alexia Tyler King, Tarun N. Bhatia, Anna N. Ligezka, Karen Driesen, Rameen Shah, Bart Ghesquière, Akhilesh Pandey, Nael Nadif Kasri, Steven A. Sloan, Eva Morava, Tamas Kozicz
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113883- (2024)
Summary: Phosphomannomutase 2-congenital disorder of glycosylation (PMM2-CDG) is a rare inborn error of metabolism caused by deficiency of the PMM2 enzyme, which leads to impaired protein glycosylation. While the disorder presents with primarily neur
Externí odkaz:
https://doaj.org/article/024f4555f92c4b3d86ca5b20b595064b
Autor:
Tarun N. Bhatia, Anuj S. Jamenis, Muslim Abbas, Rachel N. Clark, Kristin M. Miner, Manisha N. Chandwani, Roxanne E. Kim, William Hilinski, Lauren A. O'Donnell, Kelvin C. Luk, Yejie Shi, Xiaoming Hu, Jun Chen, Jeffrey L. Brodsky, Rehana K. Leak
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106196- (2023)
Reactive microglia are observed with aging and in Lewy body disorders, including within the olfactory bulb of men with Parkinson's disease. However, the functional impact of microglia in these disorders is still debated. Resetting these reactive cell
Externí odkaz:
https://doaj.org/article/9721d7f26b7b4036901bb4feac886942
Autor:
Tarun N. Bhatia, Deepti B. Pant, Elizabeth A. Eckhoff, Rachel N. Gongaware, Timothy Do, Daniel F. Hutchison, Amanda M. Gleixner, Rehana K. Leak
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
In order to fulfill their evolutionary role as support cells, astrocytes have to tolerate intense oxidative stress under conditions of brain injury and disease. It is well known that astrocytes exposed to mild oxidative stress are preconditioned agai
Externí odkaz:
https://doaj.org/article/44967618233b4c5fa0955b92d1a73725
Autor:
Xiaoming Hu, Kristin M. Miner, Rehana K. Leak, Tarun N. Bhatia, Jeffrey L. Brodsky, Anuj S Jamenis, Patrick G. Needham, Nevil Abraham, Kelvin C. Luk, Rachel N Clark, Elizabeth A. Eckhoff, Peter Wipf
Publikováno v:
Neurotherapeutics
The role of molecular chaperones, such as heat shock protein 70 (Hsp70), is not typically studied as a function of biological sex, but by addressing this gap we might improve our understanding of proteinopathic disorders that predominate in one sex.
Autor:
Anuj S. Jamenis, Tarun N. Bhatia, Kristin M. Miner, Krishna Kaku, Yesha Shah, Brett A. DeMarco, Rachel N. Clark, Aleem Gangjee, Rehana K. Leak
Publikováno v:
The FASEB Journal. 36
Autor:
Kristin M. Miner, Tarun N. Bhatia, Anuj S. Jamenis, Rachel N. Clark, Nevil Abraham, Dhivyaa Rajasundaram, Sylvie Sauvaigo, R. A. Stetler, Jun Chen, Laurie H. Sanders, Kelvin C. Luk, Rehana K. Leak
Publikováno v:
The FASEB Journal. 36
Autor:
Kristin M. Miner, Anuj S. Jamenis, Tarun N. Bhatia, Rachel N. Clark, Dhivyaa Rajasundaram, Sylvie Sauvaigo, Daniel M. Mason, Jessica M. Posimo, Nevil Abraham, Brett A. DeMarco, Xiaoming Hu, R. Anne Stetler, Jun Chen, Laurie H. Sanders, Kelvin C. Luk, Rehana K. Leak
Publikováno v:
Progress in neurobiology. 216
Lewy body disorders are characterized by oxidative damage to DNA and inclusions rich in aggregated forms of α-synuclein. Among other roles, apurinic/apyrimidinic endonuclease 1 (APE1) repairs oxidative DNA damage, and APE1 polymorphisms have been li
Autor:
Kandarp M. Dave, Donna B. Stolz, Venugopal R. Venna, Victoria A. Quaicoe, Michael E. Maniskas, Michael John Reynolds, Riyan Babidhan, Duncan X. Dobbins, Maura N. Farinelli, Abigail Sullivan, Tarun N. Bhatia, Hannah Yankello, Rohan Reddy, Younsoo Bae, Rehana K. Leak, Sruti S. Shiva, Louise D. McCullough, Devika S Manickam
Ischemic stroke causes brain endothelial cell (BEC) death and damages tight junction integrity of the blood-brain barrier (BBB). We harnessed the innate mitochondrial load of endothelial cell-derived extracellular vesicles (EVs) and utilized mixtures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bd9baa88f4bdee3a273561f9c25437
https://doi.org/10.1101/2021.10.29.466491
https://doi.org/10.1101/2021.10.29.466491
Autor:
Rehana K. Leak, John F. Stolz, Kristin M. Miner, Kelvin C. Luk, Daniel M. Mason, Yaqin Wang, Sara A. Trbojevic, Tarun N. Bhatia
Publikováno v:
Brain Pathol
At early disease stages, Lewy body disorders are characterized by limbic vs. brainstem α-synucleinopathy, but most preclinical studies have focused solely on the nigrostriatal pathway. Furthermore, male gender and advanced age are two major risk fac
Publikováno v:
CNS Neuroscience & Therapeutics
Stroke is a leading cause of disability and mortality, with limited treatment options. After stroke injury, microglia and CNS‐resident macrophages are rapidly activated and regulate neuropathological processes to steer the course of functional reco