Lecanemab for Alzheimer's disease: new hope or another false dawn?

Autor: Mark Dashwood, Tarun Kuruvilla

Publikováno v: Progress in Neurology and Psychiatry. 27:4-6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bb6eb215cd7c8ff4804a481c6663c46
https://doi.org/10.1002/pnp.772

Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial): a double-blind, randomised, placebo-controlled, phase 2 trial

Autor: Patrick Gavin Kehoe, Nicholas Turner, Beth Howden, Lina Jarutyte, Shona Louise Clegg, Ian Brian Malone, Josephine Barnes, Casper Nielsen, Carole Hélène Sudre, Aileen Wilson, Ngoc Jade Thai, Peter Sinclair Blair, Elizabeth Coulthard, Janet Athene Lane, Peter Passmore, Jodi Taylor, Henk-Jan Mutsaerts, David Lee Thomas, Nick Charles Fox, Ian Wilkinson, Yoav Ben-Shlomo, Kirsty Harkness, Tarun Kuruvilla, Rupert McShane, Peter Connelly, Gordon Duncan, Lucy Calvert, Alasdair Lawrie, Matthew Sheridan, Eric Jackson, Bernard Udeze, Stephen Pearson, Tobias Langheinrich, Suvarna Wagle, Joseph Butchart, Ajay Macharouthu, Andrew Donaldson, Wendy Neil, Vivek Pattan, David Findlay, Alan Thomas, Robert Barber, Andrew Byrne, Madhusudan Dalvi, Rashi Negi, Bernadette McGuinness

Publikováno v: The Lancet. Neurology
Lancet Neurology, 20(11), 895-906. Lancet Publishing Group
Kehoe, P G, Turner, N, Howden, B, Jarutyte, L, Clegg, S L, Malone, I B, Barnes, J, Nielsen, C, Sudre, C H, Wilson, A, Thai, N J, Blair, P S, Coulthard, E, Lane, J A, Passmore, P, Taylor, J, Mutsaerts, H-J, Thomas, D L, Fox, N C, Wilkinson, I, Ben-Shlomo, Y & RADAR investigators 2021, ' Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial) : a double-blind, randomised, placebo-controlled, phase 2 trial ', Lancet Neurology, vol. 20, no. 11, pp. 895-906 . https://doi.org/10.1016/S1474-4422(21)00263-5
RADAR investigators 2021, ' Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial): a double-blind, randomised, placebo-controlled, phase 2 trial ', The Lancet. Neurology, vol. 20, no. 11, pp. 895-906 . https://doi.org/10.1016/S1474-4422(21)00263-5
2021, ' Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial) : a double-blind, randomised, placebo-controlled, phase 2 trial ', Lancet Neurology, vol. 20, no. 11, pp. 895-906 . https://doi.org/10.1016/S1474-4422(21)00263-5
Kehoe, P G, Turner, N, Howden, B, Jarutyte, L, Clegg, S L, Malone, I B, Barnes, J, Nielsen, C, Sudre, C H, Wilson, A, Thai, N J, Blair, P S, Coulthard, E, Lane, J A, Passmore, P, Taylor, J, Mutsaerts, H-J, Thomas, D L, Fox, N C, Wilkinson, I & Ben-Shlomo, Y 2021, ' Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial): a double-blind, randomised, placebo-controlled, phase 2 trial ', Lancet Neurology, vol. 20, no. 11, pp. 895-906 .

BACKGROUND: Drugs modifying angiotensin II signalling could reduce Alzheimer's disease pathology, thus decreasing the rate of disease progression. We investigated whether the angiotensin II receptor antagonist losartan, compared with placebo, could r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a28429bb9f725cd7e59ecafb894961
http://europepmc.org/articles/PMC8528717

Confusion-inducing drugs in a memory assessment service: an audit

Autor: Clara Martinez-Clavera, Tarun Kuruvilla, Eva Bowditch, Prianka Padmanathan

Publikováno v: Progress in Neurology and Psychiatry. 22:15-18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d5379281d2eac49aa88ffe3760664c6
https://doi.org/10.1002/pnp.508

Evidence for neuroinflammation in Alzheimer's disease

Autor: Emma Phillips, Maya Biju, Rui Zheng, Anna Walters, Tarun Kuruvilla

Publikováno v: Progress in Neurology and Psychiatry. 20:25-31

New understanding in neuroscience has established that alongside the amyloid plaques, neurofibrillary tangles and atrophy, the neuroinflammation triggered by the CNS's innate immune response plays a central role in the pathogenesis of Alzheimer's dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d5c6e7ceab9d720f96e378372deaa5b
https://doi.org/10.1002/pnp.444

Population-based screening for dementia: controversy and current status

Autor: Emma Philips, Maya Biju, Anna Walters, Tarun Kuruvilla

Publikováno v: Progress in Neurology and Psychiatry. 20:6-10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b0434f1437b407394efc1cb8ed2782c
https://doi.org/10.1002/pnp.410