Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Tarsha Ward"'
GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm
Autor:
Arun Sharma, Lauren K Wasson, Jon AL Willcox, Sarah U Morton, Joshua M Gorham, Daniel M DeLaughter, Meraj Neyazi, Manuel Schmid, Radhika Agarwal, Min Young Jang, Christopher N Toepfer, Tarsha Ward, Yuri Kim, Alexandre C Pereira, Steven R DePalma, Angela Tai, Seongwon Kim, David Conner, Daniel Bernstein, Bruce D Gelb, Wendy K Chung, Elizabeth Goldmuntz, George Porter, Martin Tristani-Firouzi, Deepak Srivastava, Jonathan G Seidman, Christine E Seidman, Pediatric Cardiac Genomics Consortium
Publikováno v:
eLife, Vol 9 (2020)
Damaging GATA6 variants cause cardiac outflow tract defects, sometimes with pancreatic and diaphragmic malformations. To define molecular mechanisms for these diverse developmental defects, we studied transcriptional and epigenetic responses to GATA6
Externí odkaz:
https://doaj.org/article/de48ca73426c4e9e8cd88b2b87f1b9e5
Autor:
Qi Zhang, Seong Won Kim, Joshua M. Gorham, Daniel M. DeLaughter, Tarsha Ward, Christine E. Seidman, Jonathan G. Seidman
Publikováno v:
Current protocols. 2(10)
This protocol describes a robust pipeline for simultaneously analyzing multiple samples by single-nucleus (sn)RNA-seq. cDNA obtained from each single sample are labeled with the same lipid-coupled oligonucleotide barcode (10X Genomics). Nuclei from a
Autor:
Xuebiao Yao, Shi-Yuan Cheng, Kefen Dou, Felix Aikhionbare, Jingde Zhu, Kelong Ma, Winston Thompson, Xia Ding, Chibuzo Emenari, Peng Xia, Tarsha Ward, Jian Liao, Xue Yu, Fei Gao, Hongjun Xiang, Ti Zhou, Hui Deng, Bing Wu, Jun Zhao, Zhen Guo, Dongmei Wang, Yong Chen
Supplementary Methods, Figures 1-4 from Rho Kinase Phosphorylation Promotes Ezrin-Mediated Metastasis in Hepatocellular Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e4860b063c52ca4860de6e101fcda69
https://doi.org/10.1158/0008-5472.22387211.v1
https://doi.org/10.1158/0008-5472.22387211.v1
Autor:
Bruce D. Gelb, Yuri Kim, Jonathan G. Seidman, Joshua M. Gorham, Kehan Zhang, Sylvia Varland, Christine E. Seidman, Tarsha Ward, Kris Gevaert, Richard P. Lifton, Min Young Jang, Alireza Haghighi, Alexandre C. Pereira, Elizabeth Goldmuntz, Wendy K. Chung, Jason Homsy, Warren Tai, Martina Brueckner, Jon A. L. Willcox, Christopher S. Chen, George A. Porter, Thomas Arnesen, Sarah U. Morton, Benoit G. Bruneau, H. Joseph Yost, Craig C. Benson, Evy Timmerman, Petra Van Damme, Francis Impens, Delphi Van Haver, Steven R. DePalma, Gabriela Venturini
Publikováno v:
Circ Res
CIRCULATION RESEARCH
CIRCULATION RESEARCH
Rationale: NAA15 (N-alpha-acetyltransferase 15) is a component of the NatA (N-terminal acetyltransferase complex). The mechanism by which NAA15 haploinsufficiency causes congenital heart disease remains unknown. To better understand molecular process
Autor:
Angela Tai, Elizabeth Goldmuntz, Lauren K. Wasson, Yuri Kim, Manuel Schmid, Deepak Srivastava, Steven R. DePalma, Daniel M. DeLaughter, Jonathan G. Seidman, George A. Porter, Min Young Jang, Arun Sharma, Jon A. L. Willcox, Sarah U. Morton, Alexandre C. Pereira, Radhika Agarwal, Martin Tristani-Firouzi, Seongwon Kim, Joshua M. Gorham, Christine E. Seidman, Tarsha Ward, Christopher N. Toepfer, Meraj Neyazi, Daniel Bernstein, Wendy K. Chung, Bruce D. Gelb, David A. Conner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fabd1d03a5ba415963a8fa292ca44a3
https://doi.org/10.7554/elife.53278.sa2
https://doi.org/10.7554/elife.53278.sa2
GATA6 mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm
Autor:
Min Young Jang, Yuri Kim, Daniel Bernstein, Deepak Srivastava, Jonathan G. Seidman, Elizabeth Goldmuntz, Daniel M. DeLaughter, Manuel Schmid, Christopher N. Toepfer, David A. Conner, Angela Tai, Steven R. DePalma, Alexandre C. Pereira, Bruce D. Gelb, Jon A. L. Willcox, Meraj Neyazi, George A. Porter, Arun Sharma, Radhika Agarwal, Martin Tristani-Firouzi, Tarsha Ward, Lauren K. Wasson, Sarah U. Morton, Seongwon Kim, Joshua M. Gorham, Christine E. Seidman, Wendy K. Chung
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Damaging GATA6 variants cause cardiac outflow tract defects, sometimes with pancreatic and diaphragmic malformations. To define molecular mechanisms for these diverse developmental defects, we studied transcriptional and epigenetic responses to GATA6
Autor:
Yin Zhang, Dongmei Wang, McKay Mullen, Fengsong Wang, Wendy Yao, Xueying Wang, Xuebiao Yao, Wenwen Wang, Jiying Jiang, Xinwang Cao, Ping Gui, Xuannv Zhao, Ruijun Tian, Xing Liu, Larry Brako, Xiao Yuan, Zeqi Su, Xia Ding, Phil Y. Yao, Tarsha Ward, Calmour Henry
Publikováno v:
Journal of Biological Chemistry. 292:16174-16187
Digestion in the stomach depends on acidification of the lumen. Histamine-elicited acid secretion is triggered by activation of the PKA cascade, which ultimately results in the insertion of gastric H,K-ATPases into the apical plasma membranes of pari
Autor:
Xuebiao Yao, Qi Wang, Yun Zhao, Peng R Chen, Youjun Chu, Guowei Fang, Fei Mo, Wenwen Wang, Zhen Dou, Ruoying Yu, Ping Gui, Jun Cao, Shihao Du, Lingluo Chu, Mahboob Ali, Huihui Wu, Xinjiao Gao, Jianye Zang, Jianyu Wang, Tarsha Ward, Hazrat Ismail, F.M. Yang, Xing Liu, Mingliang Ye
Publikováno v:
Journal of Molecular Cell Biology
Faithful segregation of mitotic chromosomes requires bi-orientation of sister chromatids, which relies on the sensing of correct attachments between spindle microtubules and kinetochores. Although the mechanisms underlying PLK1 activation have been e
Autor:
Seongwon Kim, Joshua M. Gorham, Christopher N. Toepfer, David A. Conner, Jon A. L. Willcox, Lauren K. Wasson, Christine E. Seidman, Megan Jang, Daniel M. DeLaughter, Tarsha Ward, Steven R. DePalma, Alexandre C. Pereira, Angela Tai, Manuel Schmid, Sarah U. Morton, Meraj Neyazi, Arun Sharma, Yuri Kim, Benoit G. Bruneau, Jon G. Seidman, Radhika Agarwal
Publikováno v:
Circulation Research. 125
The discovery of damaging gene mutations in congenital heart disease (CHD) patients enables identification of regulators of cardiac development. Exome sequencing identified de novo heterozygous loss-of-function (LoF) and missense variants in GATA6 am
Autor:
Joshua M. Gorham, Christine E. Seidman, Tarsha Ward, Arun Sharma, Min Young Jang, Alexandre C. Pereira, Jon G. Seidman, Radhika Agarwal, David M. McKean, Daniel Reichart, Daniel M. DeLaughter
Publikováno v:
Circulation Research. 125
Rationale: Neural crest cells (NCCs) play a critical role in normal cardiac development, and defects in NCCs likely cause congenital heart disease (CHD). NCCs are transient and multipotent migratory stem cells that give rise to diverse tissues, inclu