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Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

Autor: Ju, YS, Tubio, JM, Mifsud, W, Fu, B, Davies, HR, Ramakrishna, M, Li, Y, Yates, L, Gundem, G, Tarpey, PS, Behjati, S, Papaemmanuil, E, Martin, S, Fullam, A, Gerstung, M, ICGC Prostate Cancer Working Group, ICGC Bone Cancer Working Group, ICGC Breast Cancer Working Group, Nangalia, J, Green, AR, Caldas, C, Borg, Å, Tutt, A, Lee, MT, Van't Veer, LJ, Tan, BK, Aparicio, S, Span, PN, Martens, JW, Knappskog, S, Vincent-Salomon, A, Børresen-Dale, AL, Eyfjörd, JE, Flanagan, AM, Foster, C, Neal, DE, Cooper, C, Eeles, R, Lakhani, Desmedt, C, Thomas, G, Richardson, AL, Purdie, CA, Thompson, AM, McDermott, U, Yang, F, Nik-Zainal, S, Campbell, PJ, Stratton, MR

Mitochondrial genomes are separated from the nuclear genome for most of the cell cycle by the nuclear double membrane, intervening cytoplasm, and the mitochondrial double membrane. Despite these physical barriers, we show that somatically acquired mi

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Correction: Clinical findings and a DNA methylation signature in kindreds with alterations in ZNF711.

Autor: Wang J; Greenwood Genetic Center, Greenwood, SC, USA., Foroutan A; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada., Richardson E; Greenwood Genetic Center, Greenwood, SC, USA., Skinner SA; Greenwood Genetic Center, Greenwood, SC, USA., Reilly J; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada., Kerkhof J; Verspeeten Clinical Genome Centre, London Health Sciences Centre, London, ON, Canada., Curry CJ; Genetic Medicine, University of California, San Francisco/Fresno, Fresno, CA, USA., Tarpey PS; Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK., Robertson SP; Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand., Maystadt I; Centre de Génétique Humaine, Institute de Pathologie et de Génétique, Gosselies, BE, Charleroi, Belgium., Keren B; Genetic Department, La Pitie-Salpetriere Hospital, APHP.Sorbonne Universite, Paris, France., Dixon JW; Genetic Health Services New Zealand, Christchurch Hospital, Christchurch, New Zealand., Skinner C; Greenwood Genetic Center, Greenwood, SC, USA., Stapleton R; Genetic Health Services New Zealand, Christchurch Hospital, Christchurch, New Zealand., Ruaud L; Department of Genetics, APHP.Nord, Robert Debré Hospital, Paris, FR and University of Paris, UMR 1141NEURODIDEROT, INSERM, Paris, France., Gumus E; Medical Genetics Department, Mugla Sitki Kocman University, Mugla, Turkey., Lakeman P; Department of Clinical Genetics, Amsterdam University Medical Center, Amsterdam, Netherlands., Alders M; Department of Clinical Genetics, Amsterdam University Medical Center, Amsterdam, Netherlands., Tedder ML; Greenwood Genetic Center, Greenwood, SC, USA., Schwartz CE; Greenwood Genetic Center, Greenwood, SC, USA., Friez MJ; Greenwood Genetic Center, Greenwood, SC, USA., Sadikovic B; Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada.; Verspeeten Clinical Genome Centre, London Health Sciences Centre, London, ON, Canada., Stevenson RE; Greenwood Genetic Center, Greenwood, SC, USA. res@ggc.org.

Publikováno v: European journal of human genetics : EJHG [Eur J Hum Genet] 2023 Dec 01. Date of Electronic Publication: 2023 Dec 01.