Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies

Autor: Nuzzi, A, Fiasella, A, Ortega, JA, Pagliuca, C, Ponzano, S, Pizzirani, D, Bertozzi, SM, Ottonello, G, Tarozzo, G, Reggiani, A, Bandiera, T, Bertozzi, F, Piomelli, D

Publikováno v: Nuzzi, A; Fiasella, A; Ortega, JA; Pagliuca, C; Ponzano, S; Pizzirani, D; et al.(2016). Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies. European Journal of Medicinal Chemistry, 111, 138-159. doi: 10.1016/j.ejmech.2016.01.046. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7rp5j680

© 2016 Elsevier Masson SAS. All rights reserved. 4-Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate (3b) is a potent, selective and systemically active inhibitor of intracellular NAAA activity, which produces profound anti-inflammatory effects in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::564f13db6da2606e473743bd1c1ed415
http://www.escholarship.org/uc/item/7rp5j680

O-(triazolyl)methyl carbamates as a novel and potent class of Fatty Acid Amide Hydrolase (FAAH) inhibitors

Autor: Colombano, G, Albani, C, Ottonello, G, Ribeiro, A, Scarpelli, R, Tarozzo, G, Daglian, J, Jung, KM, Piomelli, D, Bandiera, T

Publikováno v: Colombano, G; Albani, C; Ottonello, G; Ribeiro, A; Scarpelli, R; Tarozzo, G; et al.(2015). O-(triazolyl)methyl carbamates as a novel and potent class of Fatty Acid Amide Hydrolase (FAAH) inhibitors. ChemMedChem, 10(2), 380-395. doi: 10.1002/cmdc.201402374. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6pg4m96n

© 2015 Wiley-VCH Verlag GmbH & Co. KGaA. Inhibition of fatty acid amide hydrolase (FAAH) activity is under investigation as a valuable strategy for the treatment of several disorders, including pain and drug addiction. A number of potent FAAH inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::5d6ebc025b913d4477b61c35a6599dee
http://www.escholarship.org/uc/item/6pg4m96n

Synthesis and structure-activity relationship (SAR) of 2-methyl-4-oxo-3- oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors

Autor: Ponzano, S, Bertozzi, F, Mengatto, L, Dionisi, M, Armirotti, A, Romeo, E, Berteotti, A, Fiorelli, C, Tarozzo, G, Reggiani, A, Duranti, A, Tarzia, G, Mor, M, Cavalli, A, Piomelli, D, Bandiera, T

Publikováno v: Ponzano, S; Bertozzi, F; Mengatto, L; Dionisi, M; Armirotti, A; Romeo, E; et al.(2013). Synthesis and structure-activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors. Journal of Medicinal Chemistry, 56(17), 6917-6934. doi: 10.1021/jm400739u. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/28k244m2

N-Acylethanolamine acid amidase (NAAA) is a lysosomal cysteine hydrolase involved in the degradation of saturated and monounsaturated fatty acid ethanolamides (FAEs), a family of endogenous lipid agonists of peroxisome proliferator-activated receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::47b3328e9b18202e62ff3194f05b2dbc
http://www.escholarship.org/uc/item/28k244m2

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