Zobrazeno 1 - 10
of 442
pro vyhledávání: '"Taroh Kinoshita"'
Autor:
Yoshiko Murakami, Saori Umeshita, Kae Imanishi, Yoshichika Yoshioka, Akinori Ninomiya, Takehiko Sunabori, Shibi Likhite, Masato Koike, Kathrin C. Meyer, Taroh Kinoshita
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101176- (2024)
Thirty genes are involved in the biosynthesis and modification of glycosylphosphatidylinositol (GPI)-anchored proteins, and defects in these genes cause inherited GPI deficiency (IGD). PIGA is X-linked and involved in the first step of GPI biosynthes
Externí odkaz:
https://doaj.org/article/181bb1efa9434f12a9c25cb49690553b
Autor:
Ryoko Kuwayama, Keiichiro Suzuki, Jun Nakamura, Emi Aizawa, Yoshichika Yoshioka, Masahito Ikawa, Shin Nabatame, Ken-ichi Inoue, Yoshiari Shimmyo, Keiichi Ozono, Taroh Kinoshita, Yoshiko Murakami
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Inherited GPI deficiency (IGD) is caused by PIGO mutations. Here, the authors generate a mouse model of IGD and show that AAV-mediate gene therapy, for knock-in as well as extra-chromosomal expression of Pigo cDNA, ameliorates pathology in the mice.
Externí odkaz:
https://doaj.org/article/279353779621470d85a9bf09f282cfcc
Autor:
Ikhlas Ben Ayed, Olfa Jallouli, Yoshiko Murakami, Amal Souissi, Salma Mallouli, Amal Bouzid, Fatma Kamoun, Ines Elloumi, Fakher Frikha, Abdelaziz Tlili, Sarah Weckhuysen, Taroh Kinoshita, Chahnez Charfi Triki, Saber Masmoudi
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Pathogenic germline variants in the PIGT gene are associated with the “multiple congenital anomalies–hypotonia-seizures syndrome 3” (MCAHS3) phenotype. So far, fifty patients have been reported, most of whom suffer from intractable epilepsy. Re
Externí odkaz:
https://doaj.org/article/b81bd57e58bf4419a6550dcb1a914289
Autor:
Roberta Salinas-Marín, Yoshiko Murakami, Carlos Alberto González-Domínguez, Mario Ernesto Cruz-Muñoz, Héctor Manuel Mora-Montes, Eva Morava, Taroh Kinoshita, Susana Monroy-Santoyo, Iván Martínez-Duncker
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
A subgroup of congenital disorders of glycosylation (CDGs) includes inherited GPI-anchor deficiencies (IGDs) that affect the biosynthesis of glycosylphosphatidylinositol (GPI) anchors, including the first reaction catalyzed by the X-linked PIGA. Here
Externí odkaz:
https://doaj.org/article/ae958a3ab8354ab78668866d0b631d0e
Autor:
Si-Si Liu, Yi-Shi Liu, Xin-Yu Guo, Yoshiko Murakami, Ganglong Yang, Xiao-Dong Gao, Taroh Kinoshita, Morihisa Fujita
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Liu et al. construct a knock out cell library of genes involved in the biosynthesis of glycosylphosphatidylinositol (GPI)-anchored protein (GPI-APs) from HEK-293 cells and analyzed the surface expression and sensitivity to phosphatidylinositol-specif
Externí odkaz:
https://doaj.org/article/3671a2fc33684958a4cc3730bc6d41d1
Autor:
Yicheng Wang, Yusuke Maeda, Yi-Shi Liu, Yoko Takada, Akinori Ninomiya, Tetsuya Hirata, Morihisa Fujita, Yoshiko Murakami, Taroh Kinoshita
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Glycosylphosphatidylinositol (GPI) anchors are found on many cell surface proteins but their biosynthesis is not fully understood. Here, the authors identify genes involved in GPI galactosylation and reveal functional connections between GPI processi
Externí odkaz:
https://doaj.org/article/af50b6c2882743e491efc238b271b2f7
Autor:
Taroh Kinoshita
Publikováno v:
Open Biology, Vol 10, Iss 3 (2020)
At least 150 human proteins are glycosylphosphatidylinositol-anchored proteins (GPI-APs). The protein moiety of GPI-APs lacking transmembrane domains is anchored to the plasma membrane with GPI covalently attached to the C-terminus. The GPI consists
Externí odkaz:
https://doaj.org/article/20b6130ff029439a9d8b3b2d87237932
Autor:
Tetsuya Hirata, Sushil K. Mishra, Shota Nakamura, Kazunobu Saito, Daisuke Motooka, Yoko Takada, Noriyuki Kanzawa, Yoshiko Murakami, Yusuke Maeda, Morihisa Fujita, Yoshiki Yamaguchi, Taroh Kinoshita
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Mammalian GPI membrane anchors are modified by GalNAc to confer structural diversity but the biosynthetic pathway is poorly understood. Here, the authors identify and characterize the Golgi-resident GPI-GalNAc transferase PGAP4, providing insights in
Externí odkaz:
https://doaj.org/article/476885486e374cb9b0577fcd177b83ae
Autor:
Si-Si Liu, Fei Jin, Yi-Shi Liu, Yoshiko Murakami, Yukihiko Sugita, Takayuki Kato, Xiao-Dong Gao, Taroh Kinoshita, Motoyuki Hattori, Morihisa Fujita
Publikováno v:
Molecules, Vol 26, Iss 18, p 5462 (2021)
Glycosylphosphatidylinositol (GPI) anchor modification is a posttranslational modification of proteins that has been conserved in eukaryotes. The biosynthesis and transfer of GPI to proteins are carried out in the endoplasmic reticulum. Attachment of
Externí odkaz:
https://doaj.org/article/1243bbe3a95b4aab90632b9f330bf8b5
Autor:
Taroh Kinoshita, Morihisa Fujita
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 1, Pp 6-24 (2016)
Glycosylphosphatidylinositols (GPIs) act as membrane anchors of many eukaryotic cell surface proteins. GPIs in various organisms have a common backbone consisting of ethanolamine phosphate (EtNP), three mannoses (Mans), one non-N-acetylated glucosami
Externí odkaz:
https://doaj.org/article/f90fef0b960c45e39ce31fce9a4a7b5c