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Characterization of CS-023 (RO4908463), a Novel Parenteral Carbapenem Antibiotic, and Meropenem as Substrates of Human Renal Transporters

Autor: Emi Kamiyama, Takahiro Shibayama, Daisuke Sugiyama, Taro Tokui, Toshihiko Ikeda, Takashi Hirota

Publikováno v: Drug Metabolism and Pharmacokinetics. 22:41-47

To characterize the renal handling of CS-023 (RO4908463), a novel parenteral carbapenem antibiotic, and meropenem in humans, we examined their affinities as substrates to human renal transporters. In vitro studies on the uptake of [14C]CS-023 and [14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e45118d1dc9399b66a858044beb3cf2
https://doi.org/10.2133/dmpk.22.41

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OATP1B1, OATP1B3, AND MRP2 ARE INVOLVED IN HEPATOBILIARY TRANSPORT OF OLMESARTAN, A NOVEL ANGIOTENSIN II BLOCKER

Autor: Takaaki Abe, Rie Nakagomi-Hagihara, Daisuke Nakai, Toshihiko Ikeda, Kenji Kawai, Taro Tokui, Yasushi Yoshigae

Publikováno v: Drug Metabolism and Disposition. 34:862-869

Hepatic uptake and biliary excretion of olmesartan, a new angiotensin II blocker, were investigated in vitro using human hepatocytes, cells expressing uptake transporters and canalicular membrane vesicles, and in vivo using Eisai hyperbilirubinemic r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646e2f03443c62b095e0ac21a0711870
https://doi.org/10.1124/dmd.105.008888

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Renal handling of CS-023 (RO4908463), a novel parenteral carbapenem antibiotic, in rabbits in comparison with meropenem

Autor: T. Shibayama, N. Yamamura, Takashi Hirota, T. Ikeda, Taro Tokui, Y. Matsushita

Publikováno v: Xenobiotica. 36:1273-1287

The plasma half-life of CS-023 (RO4908463), a novel parenteral carbapenem antibiotic, is longer than that of meropenem in animals and humans. To address this issue, renal clearance studies were conducted in rabbits. A constant rate infusion of CS-023

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a96ddf98d5439575f620b8630e526dc
https://doi.org/10.1080/00498250600944326

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Enhancement of the Inhibitory Activity of oatp Antisense Oligonucleotides by Incorporation of 2‘-O,4‘-C-Ethylene-Bridged Nucleic Acids (ENA) without a Loss of Subtype Selectivity

Autor: Miho Takagi, Daisuke Nakai, Koji Morita, Makoto Koizumi, Taro Tokui, Rie Nakagomi

Publikováno v: Biochemistry. 43:4501-4510

Antisense oligonucleotides (AONs) that specifically target the genes of rat organic anion transporting polypeptide (oatp) subtypes were selected by using antisense in vitro selection (AIVS) and a conventional gene alignment program (GAP). When we inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031fa11dea37b17b67598a938a22b94a
https://doi.org/10.1021/bi035847x

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Pyroglutamyl Aminopeptidase I, as a Drug Metabolizing Enzyme, Recognizes Xenobiotic Substrates Containing L-2-Oxothiazolidine-4-carboxylic Acid

Autor: Taro Tokui, Fujio Saito, Koji Abe, Makiko Yamada

Publikováno v: Biological and Pharmaceutical Bulletin. 27:113-116

Pyroglutamyl aminopeptidase I (PAP-I) is known for specifically removing the L-pyroglutamate (L-pGlu) residue from the amino terminus of L-pGlu proteins and peptides. In general, substrate recognition of PAP-I as to L-pGlu moiety is tightly regulated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787676b327071553710d3c3cf5c14305
https://doi.org/10.1248/bpb.27.113

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Marginal Involvement of Pyroglutamyl Aminopeptidase I in Metabolism of Thyrotropin-Releasing Hormone in Rat Brain

Autor: Kuniaki Fukuda, Taro Tokui, Koji Abe

Publikováno v: Biological and Pharmaceutical Bulletin. 27:1197-1201

On thyrotropin-releasing hormone (TRH) metabolism, pyroglutamyl aminopeptidase II (PAP-II), a zinc-dependent ectoenzyme primarily located in the central nervous system, is believed to play a predominant role. Recently we cloned pyroglutamyl aminopept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6253e0edbc15cdc5eb5e937b25e6d41
https://doi.org/10.1248/bpb.27.1197

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Novel Organic Nitrate Prodrug 4(R)-N-(2-Nitroxyethyl)-2-Oxothiazolidine-4-Carboxamide (RS-7897) Serves as a Xenobiotic Substrate for Pyroglutamyl Aminopeptidase I in Dogs

Autor: Hiroshi Mizuno, Koji Abe, Toshihiko Ikeda, Ryosuke Yorikane, Yuko Matsuoka, Taro Tokui, Toshio Terao, Makiko Yamada

Publikováno v: Drug Metabolism and Pharmacokinetics. 18:373-380

Summary: RS-7897, a novel organic nitrate, structurally contains aminoethylnitrate (AEN) and L-2oxothiazolidine-4-carboxylic acid (L-OTCA), which are linked together via an amide bond. Vasodilating activity of RS-7897 was 130 times weaker than that o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5dfc8c2c0b6d4e22a6d29be5c2595ad
https://doi.org/10.2133/dmpk.18.373

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Hydrolysis of Synthetic Substrate, L-Pyroglutamyl p-Nitroanilide is Catalyzed Solely by Pyroglutamyl Aminopeptidase I in Rat Liver Cytosol

Autor: Koji Abe, Toshihiko Ikeda, Nobuaki Watanabe, Taro Tokui, Makiko Yamada, Toshiyuki Kosaka

Publikováno v: Biological & Pharmaceutical Bulletin. 26:1528-1533

Pyroglutamyl aminopeptidase I (PAP-I) is a cytosolic cysteine peptidase, which hydrolytically removes the L-pyroglutamate residue from the amino terminus of endogenous proteins and peptides. L-Pyroglutamyl p-nitroanilide serves as the synthetic subst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::831455e6f6fb66b37bc6a2e796da2580
https://doi.org/10.1248/bpb.26.1528

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