Elucidation of the biodegradation pathways of bis(2-hydroxyethyl) terephthalate and dimethyl terephthalate under anaerobic conditions revealed by enrichment culture and microbiome analysis

Autor: Kyohei Kuroda, Takashi Narihiro, Yuki Nakaya, Taro Q.P. Noguchi, Ryota Maeda, Masaru K. Nobu, Yuki Ohnishi, Yasuhiro Kumaki, Tomoyasu Aizawa, Hisashi Satoh

Publikováno v: Chemical Engineering Journal. 450:137916

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21dadce56232a600f9aafc894bca3757
https://doi.org/10.1016/j.cej.2022.137916

Real-Time 3D Imaging and Inhibition Analysis of Various Amyloid Aggregations Using Quantum Dots

Autor: Taro Q.P. Noguchi, Masahiro Kuragano, Xuguang Lin, Kiyotaka Tokuraku, Reina Tainaka, Keiya Shimamori, Nuomin Galaqin

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 6
International Journal of Molecular Sciences, Vol 21, Iss 6, p 1978 (2020)

Amyloidosis refers to aggregates of protein that accumulate and are deposited as amyloid fibrils into plaques. When these are detected in organs, they are the main hallmark of Alzheimer&rsquo
s disease, Parkinson&rsquo
s disease, and other

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd520afbcc0ca18c53887161cc7c8462
http://hdl.handle.net/10258/00010219

Rapid Nucleotide Exchange Renders Asp-11 Mutant Actins Resistant to Depolymerizing Activity of Cofilin, Leading to Dominant Toxicity in Vivo

Autor: Jun Nakajima, Taro Q.P. Uyeda, Nobuhisa Umeki, Kohji Ito, Akira Nagasaki, Keiko Hirose, Taro Q.P. Noguchi, Kiyotaka Tokuraku

Publikováno v: JOURNAL OF BIOLOGICAL CHEMISTRY. 288(3):1739-1749

Conserved Asp-11 of actin is a part of the nucleotide binding pocket, and its mutation to Gln is dominant lethal in yeast, whereas the mutation to Asn in human alpha-actin dominantly causes congenital myopathy. To elucidate the molecular mechanism of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52dba1f8f42dbb096b7b6274c25f01bd
http://hdl.handle.net/10258/00010361

G146V Mutation at the Hinge Region of Actin Reveals a Myosin Class-specific Requirement of Actin Conformations for Motility

Autor: Noriyuki Demizu, Kiyotaka Tokuraku, Nobuhisa Umeki, Taro Q.P. Noguchi, Taro Q.P. Uyeda, Toshio Yanagida, Kohji Ito, Atsuko H. Iwane, Tomotaka Komori

Publikováno v: Journal of Biological Chemistry. 287:24339-24345

The G146V mutation in actin is dominant lethal in yeast. G146V actin filaments bind cofilin only minimally, presumably because cofilin binding requires the large and small actin domains to twist with respect to one another around the hinge region con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31ef9d80ec51f524582aa26a6272408
https://doi.org/10.1074/jbc.m111.321752

Screening of novel dominant negative mutant actins using glycine targeted scanning identifies G146V actin that cooperatively inhibits cofilin binding

Autor: Ryo Toya, Kiyotaka Tokuraku, Taro Q.P. Noguchi, Taro Q.P. Uyeda, Hironori Ueno

Publikováno v: Biochemical and Biophysical Research Communications. 396:1006-1011

A number of studies suggested that the structure of actin filaments changes by interaction with actin-binding proteins such as cofilin and myosin, and that the conformational changes of the actin subunits within a filament are cooperative. To underst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741671e07bc9be8db8896defb7102fd6
https://doi.org/10.1016/j.bbrc.2010.05.047