Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Taro Kanamaru"'
Publikováno v:
European Journal of Pharmaceutical Sciences. 42:392-399
Oral bioavailability of DX-9065, a factor Xa inhibitor, was only 3% when it was administered as a conventional capsule formulation in fasted humans, and was further reduced to about one-tenth when it was administered to fed humans. The poor absorptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a2445cd31a6b4f4d5dcd2cb14d2b3d
https://doi.org/10.1016/j.ejps.2011.01.003
https://doi.org/10.1016/j.ejps.2011.01.003
Autor:
Shuichi Yada, Tsutomu Konno, Hiroaki Nakagami, Sachiko Fukui, Taro Kanamaru, Shinichiro Tajiri, Kazuhiro Yoshida, Yasue Hosoi
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 75:238-244
The purpose of this study was to develop a new method using beagle dogs in order to evaluate the colonic absorption properties of oral extended-release (ER) solid dosage forms. The established method is not only noninvasive and inexpensive but full-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a65e8df3f25f1c78efb766e88bb86d
https://doi.org/10.1016/j.ejpb.2010.03.009
https://doi.org/10.1016/j.ejpb.2010.03.009
Autor:
Shinichiro, Tajiri, Taro, Kanamaru, Makoto, Kamada, Kamada, Makoto, Tsutomu, Konno, Hiroaki, Nakagami
Publikováno v:
International Journal of Pharmaceutics. 383:99-105
The objective of the present work is to develop an extended-release dosage form of cevimeline. Two types of extended-release tablets (simple matrix tablets and press-coated tablets) were prepared and their potential as extended-release dosage forms w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33b982a2cafafefb6d6f0f34a95f9a8
https://doi.org/10.1016/j.ijpharm.2009.09.007
https://doi.org/10.1016/j.ijpharm.2009.09.007
Publikováno v:
Journal of Drug Delivery Science and Technology. 20:213-218
Extended-release tablets (ER) of cevimeline hydrochloride were prepared and in vivo absorptions following oral administration to beagle dogs were investigated. These in vivo studies were conducted with or without taking into account the gastrointesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::667d72715995cadcf9f1d120176f869d
https://doi.org/10.1016/s1773-2247(10)50032-7
https://doi.org/10.1016/s1773-2247(10)50032-7
Autor:
Dolly A. Parasrampuria, Yoshimasa Shimoto, Taro Kanamaru, Satoshi Kunitada, Ian R. Wilding, Koichiro Ogata, Alyson Connor
Publikováno v:
Journal of Clinical Pharmacology
Two studies in healthy subjects assessed the absorption of edoxaban when delivered to specific locations within the gastrointestinal tract using Enterion capsules. In study 1 (single‐dose, 4‐way crossover), 8 participants received edoxaban 60 mg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f172441a11d7d7531af0dc3aa67ed33a
https://pubmed.ncbi.nlm.nih.gov/25969414
https://pubmed.ncbi.nlm.nih.gov/25969414
Publikováno v:
Journal of Drug Targeting. 5:235-245
The biological effects and cellular uptake of human c-myc antisense oligonucleotides and their liposome complexes were investigated in vitro using human promonocytic leukemia U937 cells. Antisense phosphorothioate oligonucleotides (S-Oligo) significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4a7ae15feb66845391b369840ed076
https://doi.org/10.3109/10611869808995878
https://doi.org/10.3109/10611869808995878
Publikováno v:
Antisense and Nucleic Acid Drug Development. 6:177-183
The objective of this study was to examine the hepatic disposition characteristics of 20-mer model phosphodiester oligonucleotide (PO) and its partially phosphorothioated (PS3) and fully phosphorothioated (PS) derivatives in the single-pass isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809ec44e84ab85482f4f4f002a95d8e6
https://doi.org/10.1089/oli.1.1996.6.177
https://doi.org/10.1089/oli.1.1996.6.177
Autor:
Hiroaki Nakagami, Taro Kanamaru, Yoshimine Fujii, Hiroshi Kikuchi, Shinji Yamashita, Mitsuru Akashi, Shinji Sakuma
Publikováno v:
International journal of pharmaceutics. 421(2)
A clinical trial of (2S)-2-[4-[[(3S)-1-acetimidoyl-3-pyrrolidinyl]oxy]phenyl]-3-(7-amidino-2-naphtyl) propanoic acid (DX-9065) revealed that its oral bioavailability was only 3% when it was administered as a conventional capsule formulation. The low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e8c2fd91d39c0af25518020715979c
https://pubmed.ncbi.nlm.nih.gov/22001539
https://pubmed.ncbi.nlm.nih.gov/22001539
Autor:
Hiroaki Nakagami, Shuichi Yada, Taro Kanamaru, Tsutomu Konno, Yasue Hosoi, Kazuhiro Yoshida, Shinichiro Tajiri
Publikováno v:
Chemicalpharmaceutical bulletin. 58(10)
After the dosing of an extended-release (ER) formulation, compounds may exist in solutions at various concentrations in the colon because the drugs are released at various speeds from the ER dosage form. The aim of this study was to investigate the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f0115a49cc7fdc4b1a328ae2da1b9c
https://pubmed.ncbi.nlm.nih.gov/20930393
https://pubmed.ncbi.nlm.nih.gov/20930393
Autor:
Mitsuru Hashida, Ram I. Mahato, Mitsunobu Yoshida, Yoshinobu Takakura, Takehiko Nomura, Kenzo Sawai, Taro Kanamaru
Publikováno v:
Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems ISBN: 9784431658856
In order to construct the strategy for in vivo antisense oligonucleotide delivery systems, pharmacokinetic properties of a model antisense oligonucleotide, c-myc antisense 20-mer, were studied at organ level using organ perfusion experiments. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f29ab0da9b9d5300a2a5db7eb06439ed
https://doi.org/10.1007/978-4-431-65883-2_114
https://doi.org/10.1007/978-4-431-65883-2_114
