Výsledky vyhledávání - "Taro E. Akiyama"

Akademický článek

Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis

Publikováno v: Cell Reports Medicine, Vol 1, Iss 4, Pp 100056- (2020)

Summary: Fibrosis, or the accumulation of extracellular matrix, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, we cross-examine human primary cells from various tissues treated with TGF-β, a

Externí odkaz: https://doaj.org/article/063a70c64d8f4793abcfad76e4a93d9a

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Akademický článek

Effects of small interfering RNA-mediated hepatic glucagon receptor inhibition on lipid metabolism in db/db mice[S]

Autor: Seongah Han, Taro E. Akiyama, Stephen F. Previs, Kithsiri Herath, Thomas P. Roddy, Kristian K. Jensen, Hong-Ping Guan, Beth A. Murphy, Lesley A. McNamara, Xun Shen, Walter Strapps, Brian K. Hubbard, Shirly Pinto, Cai Li, Jing Li

Publikováno v: Journal of Lipid Research, Vol 54, Iss 10, Pp 2615-2622 (2013)

Hepatic glucose overproduction is a major characteristic of type 2 diabetes. Because glucagon is a key regulator for glucose homeostasis, antagonizing the glucagon receptor (GCGR) is a possible therapeutic strategy for the treatment of diabetes melli

Externí odkaz: https://doaj.org/article/1d1d5798fd99409895b2d79ffd6971d0

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Endothelial Cell–Targeted Deletion of PPARγBlocks Rosiglitazone-Induced Plasma Volume Expansion and Vascular Remodeling in Adipose Tissue

Autor: Lesley Mcnamara, Christopher J. Nicol, Emanuel Zycband, C. H. Chang, Haiying Liu, Elizabeth Lightbody, Neelam Sharma, Frank J. Gonzalez, Rachel E. Rubino, Jia Yue Shi, Taro E. Akiyama, Joel P. Berger, Graham Skelhorne-Gross, John Woods

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 368:514-523

Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor γ (PPARγ) agonists that represent an effective class of insulin-sensitizing agents; however, clinical use is associated with weight gain and peripheral edema. To elucidate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2adc48a9d8a14f64019db9af30380e58
https://doi.org/10.1124/jpet.118.250985

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Discovery of a new class of integrin antibodies for fibrosis

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Lung fibrosis, or the scarring of the lung, is a devastating disease with huge unmet medical need. There are limited treatment options and its prognosis is worse than most types of cancer. We previously discovered that MK-0429 is an equipotent pan-in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecfe11e15ed0f1957b9c142f77bf8253
http://europepmc.org/articles/PMC7822819

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Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis

Publikováno v: Cell Reports Medicine
Cell Reports Medicine, Vol 1, Iss 4, Pp 100056-(2020)

Summary Fibrosis, or the accumulation of extracellular matrix, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, we cross-examine human primary cells from various tissues treated with TGF-β, as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfdffc0cd9c8343fd1d503ee93abf772
http://europepmc.org/articles/PMC7659620

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Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition

Publikováno v: ACS Medicinal Chemistry Letters. 9:1082-1087

[Image: see text] We report new SSTR5 antagonists with enhanced potency, subtype selectivity, and minimal off-target activities as compared to previously reported compounds. Starting from the reported SSTR5 antagonist 1, we systematically surveyed ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f799c113adab203716f4e156f34e4f72
https://doi.org/10.1021/acsmedchemlett.8b00305

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Ketohexokinase knockout mice, a model for essential fructosuria, exhibit altered fructose metabolism and are protected from diet-induced metabolic defects

Autor: Thomas W. Rosahl, Jin Cao, Kithsiri Herath, Ku Lu, Guillaume Pavlovic, Gaochao Zhou, Taro E. Akiyama, Corin O. Miller, Cai Li, Xiaodong Yang, Roger Askew

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 315:E386-E393

Fructose consumption in humans and animals has been linked to enhanced de novo lipogenesis, dyslipidemia, and insulin resistance. Hereditary deficiency of ketohexokinase (KHK), the first enzymatic step in fructose metabolism, leads to essential fruct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5919e13d4211b01af9fbec4c5834b6
https://doi.org/10.1152/ajpendo.00027.2018

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CM-101: Type I Collagen–targeted MR Imaging Probe for Detection of Liver Fibrosis

Publikováno v: Radiology. 287:581-589

Purpose To evaluate the biodistribution, metabolism, and pharmacokinetics of a new type I collagen-targeted magnetic resonance (MR) probe, CM-101, and to assess its ability to help quantify liver fibrosis in animal models. Materials and Methods Biodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2e99231bada8f3d04ff41e46cebdd9
https://doi.org/10.1148/radiol.2017170595

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Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with in Vivo Activity in Rodents

Publikováno v: ACS Medicinal Chemistry Letters. 8:96-101

GPR120 (FFAR4) is a fatty acid sensing G protein coupled receptor (GPCR) that has been identified as a target for possible treatment of type 2 diabetes. A selective activator of GPR120 containing a chromane scaffold has been designed, synthesized, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5c4bd187bc901f79299111d7c132c57
https://doi.org/10.1021/acsmedchemlett.6b00394

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