Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Tarjei S Mikkelsen"'
Autor:
Jacob C Ulirsch, Jessica N Lacy, Xiuli An, Narla Mohandas, Tarjei S Mikkelsen, Vijay G Sankaran
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004890 (2014)
Erythropoiesis is one of the best understood examples of cellular differentiation. Morphologically, erythroid differentiation proceeds in a nearly identical fashion between humans and mice, but recent evidence has shown that networks of gene expressi
Externí odkaz:
https://doaj.org/article/62902e3ad7a84ba4a3686b75f8c39554
Autor:
Lin Jiang, Ola Wallerman, Shady Younis, Carl-Johan Rubin, Elizabeth R Gilbert, Elisabeth Sundström, Awaisa Ghazal, Xiaolan Zhang, Li Wang, Tarjei S Mikkelsen, Göran Andersson, Leif Andersson
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94187 (2014)
ZBED6 is a recently discovered transcription factor, unique to placental mammals, that has evolved from a domesticated DNA transposon. It acts as a repressor at the IGF2 locus. Here we show that ZBED6 acts as a transcriptional modulator in mouse myob
Externí odkaz:
https://doaj.org/article/8be74448d56b4cd8b456efec2dac58e5
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96615 (2014)
The in vitro process of chondrogenic differentiation of mesenchymal stem cells for tissue engineering has been shown to require three-dimensional culture along with the addition of differentiation factors to the culture medium. In general, this leads
Externí odkaz:
https://doaj.org/article/1b4253b53b1743fab6f12505282f30d7
Autor:
Ellen Markljung, Lin Jiang, Jacob D Jaffe, Tarjei S Mikkelsen, Ola Wallerman, Martin Larhammar, Xiaolan Zhang, Li Wang, Veronica Saenz-Vash, Andreas Gnirke, Anders M Lindroth, Romain Barrés, Jie Yan, Sara Strömberg, Sachinandan De, Fredrik Pontén, Eric S Lander, Steven A Carr, Juleen R Zierath, Klas Kullander, Claes Wadelius, Kerstin Lindblad-Toh, Göran Andersson, Göran Hjälm, Leif Andersson
Publikováno v:
PLoS Biology, Vol 7, Iss 12, p e1000256 (2009)
A single nucleotide substitution in intron 3 of IGF2 in pigs abrogates a binding site for a repressor and leads to a 3-fold up-regulation of IGF2 in skeletal muscle. The mutation has major effects on muscle growth, size of the heart, and fat depositi
Externí odkaz:
https://doaj.org/article/de9e5045bde1421896199b15ecd03097
Autor:
Manching Ku, Richard P Koche, Esther Rheinbay, Eric M Mendenhall, Mitsuhiro Endoh, Tarjei S Mikkelsen, Aviva Presser, Chad Nusbaum, Xiaohui Xie, Andrew S Chi, Mazhar Adli, Simon Kasif, Leon M Ptaszek, Chad A Cowan, Eric S Lander, Haruhiko Koseki, Bradley E Bernstein
Publikováno v:
PLoS Genetics, Vol 4, Iss 10, p e1000242 (2008)
In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications mark the promoters of more than 2,000 genes. To gain insight into t
Externí odkaz:
https://doaj.org/article/1453d4c8492f42d6b64093bfc315acfe
Autor:
Pardis C Sabeti, Emily Walsh, Steve F Schaffner, Patrick Varilly, Ben Fry, Holli B Hutcheson, Mike Cullen, Tarjei S Mikkelsen, Jessica Roy, Nick Patterson, Richard Cooper, David Reich, David Altshuler, Stephen O'Brien, Eric S Lander
Publikováno v:
PLoS Biology, Vol 3, Iss 11, p e378 (2005)
The C-C chemokine receptor 5, 32 base-pair deletion (CCR5-Delta32) allele confers strong resistance to infection by the AIDS virus HIV. Previous studies have suggested that CCR5-Delta32 arose within the past 1,000 y and rose to its present high frequ
Externí odkaz:
https://doaj.org/article/08cd36e6040b4450862144729a1f1a28
Autor:
Yenarae Lee, Xiaoping Yang, Lisa Brenan, Priya Pancholi, Utthara Nayar, M. Do Carmo, David E. Root, Sasha Pantel, Desiree Hernandez, J. Cordova, Cory M. Johannessen, Federica Piccioni, Tarjei S. Mikkelsen, Amanda J. Walker, Shunsuke Kitajima, Ofir Cohen, Rizwan Haq, P. Ram, Murugappan Sathappa, T. K. Hayes, Nicole S. Persky, Cong Zhu, David A. Barbie
Publikováno v:
Nature Structural & Molecular Biology. 27:92-104
Kinases are involved in disease development and modulation of their activity can be therapeutically beneficial. Drug-resistant mutant kinases are valuable tools in drug discovery efforts, but the prediction of mutants across the kinome is challenging
Autor:
Jun Feng, Drake LeFace, Aaron Cooper, Michelle L.T. Nguyen, Suchismita Mohanty, Angela C. Boroughs, Jason F. Hall, Adam J. Litterman, Jenessa B. Smith, Jeff Granja, Dina Polyak, John D. Gagnon, Jaspar Williams, Kanika Chawla, Susie Jun, Stephen Santoro, Tarjei S. Mikkelsen, Grace X.Y. Zheng, Natalie Bezman, David DeTomaso
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundIn solid tumors, CAR T cell efficacy is limited by off-tumor toxicity and suppression by the tumor microenvironment (TME). AB-X is an integrated circuit T cell (ICT cell) intended for the treatment of ovarian cancer. AB-X includes a transge
This manuscript has been withdrawn by bioRxiv as it was submitted and made public without the full consent of all the authors. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fc166cc83c7317bf84c379b6c312e26
https://doi.org/10.1101/2021.05.04.442640
https://doi.org/10.1101/2021.05.04.442640
Autor:
Michael H. Cho, Fei Du, Xiaobo Zhou, Dandi Qiao, Tarjei S. Mikkelsen, Betty Pham, Yan Li, Feng Guo, Edwin K. Silverman, Zun Zar Chi Naing, Peter J. Castaldi
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 199:52-61
Rationale: The identification of causal variants responsible for disease associations from genome-wide association studies (GWASs) facilitates functional understanding of the biological mechanisms by which those genetic variants influence disease sus