Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Tarja Porkka-heiskanen"'
Autor:
Alexandra Lahtinen, Antti Häkkinen, Sampsa Puttonen, Päivi Vanttola, Katriina Viitasalo, Tarja Porkka-Heiskanen, Mikko Härmä, Tiina Paunio
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The human DNA methylome is responsive to our environment, but its dynamics remain underexplored. We investigated the temporal changes to DNA methylation (DNAme) in relation to recovery from a shift work disorder (SWD) by performing a paired
Externí odkaz:
https://doaj.org/article/434e9f11df7f45e9bf9da206bfbe8325
Autor:
Cathalijn H. C. Leenaars, Sergey A. Savelyev, Stevie Van der Mierden, Ruud N. J. M. A. Joosten, Maurice Dematteis, Tarja Porkka-Heiskanen, Matthijs G. P. Feenstra
Publikováno v:
Journal of Circadian Rhythms, Vol 16, Iss 1 (2018)
The neuroregulator adenosine is involved in sleep-wake control. Basal forebrain (BF) adenosine levels increase during sleep deprivation. Only a few studies have addressed the effect of sleep deprivation on extracellular adenosine concentrations in ot
Externí odkaz:
https://doaj.org/article/e1df65515fad43ffb88ac3d2fbf4bff2
Autor:
Selena Marini, Olena Santangeli, Pirjo Saarelainen, Benita Middleton, Namrata Chowdhury, Debra J. Skene, Rodolfo Costa, Tarja Porkka-Heiskanen, Sara Montagnese
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Patients with liver cirrhosis can develop hyperammonemia and hepatic encephalopathy (HE), accompanied by pronounced daytime sleepiness. Previous studies with healthy volunteers show that experimental increase in blood ammonium levels increases sleepi
Externí odkaz:
https://doaj.org/article/071db9e35e114ecd94c82549d1d42731
Autor:
Katri Kantojärvi, Johanna Liuhanen, Outi Saarenpää-Heikkilä, Anna-Liisa Satomaa, Anneli Kylliäinen, Pirjo Pölkki, Julia Jaatela, Auli Toivola, Lili Milani, Sari-Leena Himanen, Tarja Porkka-Heiskanen, Juulia Paavonen, Tiina Paunio
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0180652 (2017)
Genetic variants in CACNA1C (calcium voltage-gated channel subunit alpha1 C) are associated with bipolar disorder and schizophrenia where sleep disturbances are common. In an experimental model, Cacna1c has been found to modulate the electrophysiolog
Externí odkaz:
https://doaj.org/article/41228eb76fe042e28750f726021381d8
Publikováno v:
The Scientific World Journal, Vol 3, Pp 790-798 (2003)
While the exact function of sleep remains unknown, it is evident that sleep was developed early in phylogenesis and represents an ancient and vital strategy for survival. Several pieces of evidence suggest that the function of sleep is associated wit
Externí odkaz:
https://doaj.org/article/ba55d07e2e5f48e690b28a0afaa1c4ec
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144694 (2015)
Several lines of evidence suggest a regulatory role of histamine in circadian rhythms, but little is known about signaling pathways that would be involved in such a putative role. The aim of this study was to examine whether histamine mediates its ef
Externí odkaz:
https://doaj.org/article/fd0b8410db474b6f9eee031e6fc41a35
Autor:
Vilma Aho, Hanna M Ollila, Ville Rantanen, Erkki Kronholm, Ida Surakka, Wessel M A van Leeuwen, Maili Lehto, Sampsa Matikainen, Samuli Ripatti, Mikko Härmä, Mikael Sallinen, Veikko Salomaa, Matti Jauhiainen, Harri Alenius, Tiina Paunio, Tarja Porkka-Heiskanen
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77184 (2013)
Epidemiological studies have shown that short or insufficient sleep is associated with increased risk for metabolic diseases and mortality. To elucidate mechanisms behind this connection, we aimed to identify genes and pathways affected by experiment
Externí odkaz:
https://doaj.org/article/625d9771d6214b2a8ee224d4b019e562
Autor:
Siddheshwar J Utge, Pia Soronen, Anu Loukola, Erkki Kronholm, Hanna M Ollila, Sami Pirkola, Tarja Porkka-Heiskanen, Timo Partonen, Tiina Paunio
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9259 (2010)
Disturbances in the circadian pacemaker system are commonly found in individuals with depression and sleep-related problems. We hypothesized that some of the canonical circadian clock genes would be associated with depression accompanied by signs of
Externí odkaz:
https://doaj.org/article/c574ebcdbab043a18d593cd3ff463f92
Autor:
Wessel M. A. van Leeuwen, Christer Hublin, Mikael Sallinen, Mikko Härmä, Ari Hirvonen, Tarja Porkka-Heiskanen
Publikováno v:
International Journal of Endocrinology, Vol 2010 (2010)
This study identifies the effects of sleep restriction and subsequent recovery sleep on glucose homeostasis, serum leptin levels, and feelings of subjective satiety. Twenty-three healthy young men were allocated to a control group (CON) or an experim
Externí odkaz:
https://doaj.org/article/ab6a63a0735344b7b48a8a4165546ed6
Autor:
Wessel M A van Leeuwen, Maili Lehto, Piia Karisola, Harri Lindholm, Ritva Luukkonen, Mikael Sallinen, Mikko Härmä, Tarja Porkka-Heiskanen, Harri Alenius
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4589 (2009)
BACKGROUND: Sleep restriction, leading to deprivation of sleep, is common in modern 24-h societies and is associated with the development of health problems including cardiovascular diseases. Our objective was to investigate the immunological effects
Externí odkaz:
https://doaj.org/article/27233b350547473598fc977fb0532e51