Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Tarja Malm"'
Autor:
Zengjie Xia, Emily E. Prescott, Agnieszka Urbanek, Hollie E. Wareing, Marianne C. King, Anna Olerinyova, Helen Dakin, Tom Leah, Katy A. Barnes, Martyna M. Matuszyk, Eleni Dimou, Eric Hidari, Yu P. Zhang, Jeff Y. L. Lam, John S. H. Danial, Michael R. Strickland, Hong Jiang, Peter Thornton, Damian C. Crowther, Sohvi Ohtonen, Mireia Gómez-Budia, Simon M. Bell, Laura Ferraiuolo, Heather Mortiboys, Adrian Higginbottom, Stephen B. Wharton, David M. Holtzman, Tarja Malm, Rohan T. Ranasinghe, David Klenerman, Suman De
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Which isoforms of apolipoprotein E (apoE) we inherit determine our risk of developing late-onset Alzheimer’s Disease (AD), but the mechanism underlying this link is poorly understood. In particular, the relevance of direct interactions bet
Externí odkaz:
https://doaj.org/article/65a320a335c64d1798e94a4de6e507f4
Autor:
Laura Mussalo, Riikka Lampinen, Simone Avesani, Táňa Závodná, Zdeněk Krejčík, Juho Kalapudas, Elina Penttilä, Heikki Löppönen, Anne M. Koivisto, Tarja Malm, Jan Topinka, Rosalba Giugno, Pasi Jalava, Katja M. Kanninen
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103272- (2024)
Constituents of air pollution, the ultrafine particles (UFP) with a diameter of ≤0.1 μm, are considerably related to traffic emissions. Several studies link air pollution to Alzheimer's disease (AD), yet the exact relationship between the two rema
Externí odkaz:
https://doaj.org/article/5fe4cf95d0a6478bb39e07f3433e085c
Autor:
Henna Jäntti, Steffi Jonk, Mireia Gómez Budia, Sohvi Ohtonen, Ilkka Fagerlund, Mohammad Feroze Fazaludeen, Päivi Aakko-Saksa, Alice Pebay, Šárka Lehtonen, Jari Koistinaho, Katja M. Kanninen, Pasi I. Jalava, Tarja Malm, Paula Korhonen
Publikováno v:
Particle and Fibre Toxicology, Vol 21, Iss 1, Pp 1-21 (2024)
Abstract Background Air pollution is recognized as an emerging environmental risk factor for neurological diseases. Large-scale epidemiological studies associate traffic-related particulate matter (PM) with impaired cognitive functions and increased
Externí odkaz:
https://doaj.org/article/2ffcedbcf3f049898ce5fdfb9dd94b96
Autor:
Sohvi Ohtonen, Luca Giudice, Henna Jäntti, Mohammad Feroze Fazaludeen, Anastasia Shakirzyanova, Mireia Gómez-Budia, Nelli-Noora Välimäki, Jonna Niskanen, Nea Korvenlaita, Ilkka Fagerlund, Jari Koistinaho, Mahmood Amiry-Moghaddam, Ekaterina Savchenko, Laurent Roybon, Šárka Lehtonen, Paula Korhonen, Tarja Malm
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract LRRK2-G2019S is one of the most common Parkinson’s disease (PD)-associated mutations and has been shown to alter microglial functionality. However, the impact of LRRK2-G2019S on transcriptional profile of human induced pluripotent stem cel
Externí odkaz:
https://doaj.org/article/cbf0d639bf06480ebb4d53aab63905d3
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 4, p e1012022 (2024)
The Patient Similarity Network paradigm implies modeling the similarity between patients based on specific data. The similarity can summarize patients' relationships from high-dimensional data, such as biological omics. The end PSN can undergo un/sup
Externí odkaz:
https://doaj.org/article/21386579c61b40a0a8ea737100b45f98
Autor:
Flavia Scoyni, Valeriia Sitnikova, Luca Giudice, Paula Korhonen, Davide M. Trevisan, Ana Hernandez de Sande, Mireia Gomez-Budia, Raisa Giniatullina, Irene F. Ugidos, Hiramani Dhungana, Cristiana Pistono, Nea Korvenlaita, Nelli-Noora Välimäki, Salla M. Kangas, Anniina E. Hiltunen, Emma Gribchenko, Minna U. Kaikkonen-Määttä, Jari Koistinaho, Seppo Ylä-Herttuala, Reetta Hinttala, Morten T. Venø, Junyi Su, Markus Stoffel, Anne Schaefer, Nikolaus Rajewsky, Jørgen Kjems, Mary P. LaPierre, Monika Piwecka, Jukka Jolkkonen, Rashid Giniatullin, Thomas B. Hansen, Tarja Malm
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113862- (2024)
Summary: Brain functionality relies on finely tuned regulation of gene expression by networks of non-coding RNAs (ncRNAs) such as the one composed by the circular RNA ciRS-7 (also known as CDR1as), the microRNA miR-7, and the long ncRNA Cyrano. We de
Externí odkaz:
https://doaj.org/article/3f5181ebf602423b89fa5aca16a2796d
Autor:
Martin S. Lietzén, Andrea Mari, Ronja Ojala, Jaakko Hentilä, Kalle Koskensalo, Riikka Lautamäki, Eliisa Löyttyniemi, Riitta Parkkola, Virva Saunavaara, Anna K. Kirjavainen, Johan Rajander, Tarja Malm, Leo Lahti, Juha O. Rinne, Kirsi H. Pietiläinen, Patricia Iozzo, Jarna C. Hannukainen
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1070 (2024)
Obesity and sedentarism are associated with increased liver and pancreatic fat content (LFC and PFC, respectively) as well as impaired organ metabolism. Exercise training is known to decrease organ ectopic fat but its effects on organ metabolism are
Externí odkaz:
https://doaj.org/article/04969fed64184f7bbf66f75addef9065
Autor:
Anna Jalo, Jatta S. Helin, Jaakko Hentilä, Tuuli A. Nissinen, Sanna M. Honkala, Marja A. Heiskanen, Eliisa Löyttyniemi, Tarja Malm, Jarna C. Hannukainen
Publikováno v:
Journal of Functional Morphology and Kinesiology, Vol 9, Iss 2, p 58 (2024)
Recent studies have shown that obesity and insulin resistance are associated with increased insulin-stimulated glucose uptake (GU) in the brain. Thus, insulin sensitivity seems to work differently in the brain compared to the peripheral tissues like
Externí odkaz:
https://doaj.org/article/fda9e3b0223a426a8186f7ffcdbc894d
Autor:
Henna Jäntti, Valeriia Sitnikova, Yevheniia Ishchenko, Anastasia Shakirzyanova, Luca Giudice, Irene F. Ugidos, Mireia Gómez-Budia, Nea Korvenlaita, Sohvi Ohtonen, Irina Belaya, Feroze Fazaludeen, Nikita Mikhailov, Maria Gotkiewicz, Kirsi Ketola, Šárka Lehtonen, Jari Koistinaho, Katja M. Kanninen, Damian Hernández, Alice Pébay, Rosalba Giugno, Paula Korhonen, Rashid Giniatullin, Tarja Malm
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-22 (2022)
Abstract Background Microglia are the endogenous immune cells of the brain and act as sensors of pathology to maintain brain homeostasis and eliminate potential threats. In Alzheimer's disease (AD), toxic amyloid beta (Aβ) accumulates in the brain a
Externí odkaz:
https://doaj.org/article/1e1bbd5ec02d41988a4d4b166aeb1c91
Autor:
Nikita Mikhailov, Anaïs Virenque, Kseniia Koroleva, Elisa Eme-Scolan, Matei Teleman, Ali Abdollahzadeh, Raisa Giniatullina, Oleg Gafurov, Georgii Krivoshein, Tarja Malm, Riikka H. Hämäläinen, Alejandra Sierra, Jussi Tohka, Rejane Rua, Francesco M. Noe, Rashid Giniatullin
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract A system of lymphatic vessels has been recently characterized in the meninges, with a postulated role in ‘cleaning’ the brain via cerebral fluid drainage. As meninges are the origin site of migraine pain, we hypothesized that malfunction
Externí odkaz:
https://doaj.org/article/613a7cfcc49742c485b8f4d089339b8c