Quantitative Mid‐Infrared Plasmonic Biosensing on Scalable Graphene Nanostructures

Autor: Nestor Jr. Bareza, Ewelina Wajs, Bruno Paulillo, Antti Tullila, Hannakaisa Jaatinen, Roberto Milani, Camilla Dore, Agustin Mihi, Tarja K. Nevanen, Valerio Pruneri

Publikováno v: Advanced Materials Interfaces, Vol 10, Iss 2, Pp n/a-n/a (2023)

Abstract Graphene nanostructures, exhibiting tunable and nanoscale‐confined mid‐infrared (mid‐IR) plasmons, prevail as a powerful spectroscopic platform for novel surface‐enhanced molecular identification. Particularly, graphene shows excitin

Externí odkaz: https://doaj.org/article/0e3f6a95aa214def9cf115b427c6f4d3

Utilization of Multi-Immunization and Multiple Selection Strategies for Isolation of Hapten-Specific Antibodies from Recombinant Antibody Phage Display Libraries

Autor: Antti Tullila, Tarja K. Nevanen

Publikováno v: International Journal of Molecular Sciences, Vol 18, Iss 6, p 1169 (2017)

Phage display technology provides a powerful tool for the development of novel recombinant antibodies. In this work, we optimized and streamlined the recombinant antibody discovery process for haptens as an example. A multi-immunization approach was

Externí odkaz: https://doaj.org/article/7fdf836e43064fccad2f7c9c03603be1

Structural insight to elucidate the binding specificity of the anti-cortisol Fab fragment with glucocorticoids

Autor: Veikko Eronen, Antti Tullila, Kristiina Iljin, Juha Rouvinen, Tarja K. Nevanen, Nina Hakulinen

Publikováno v: Eronen, V, Tullila, A, Iljin, K, Rouvinen, J, Nevanen, T K & Hakulinen, N 2023, ' Structural insight to elucidate the binding specificity of the anti-cortisol Fab fragment with glucocorticoids ', Journal of Structural Biology, vol. 215, no. 2, 107966 . https://doi.org/10.1016/j.jsb.2023.107966

Cortisol is a steroid hormone that is produced by the adrenal gland. It is a primary stress hormone that increases glucose levels in the blood stream. High concentrations of cortisol in the body can be used as a biomarker for acute and chronic stress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5308381e7ae11aea0e1554ad31f31abb
https://cris.vtt.fi/en/publications/06e4ad63-7650-458e-a656-421f311cea9d

Molecular super-gluing: a straightforward tool for antibody labelling and its application to mycotoxin biosensing

Autor: Fernando Pradanas-González, Bettina Glahn-Martínez, Elena Benito-Peña, Henri O. Arola, Tarja K. Nevanen, María C. Moreno-Bondi

Publikováno v: Pradanas-González, F, Glahn-Martínez, B, Benito-Peña, E, Arola, H O, Nevanen, T K & Moreno-Bondi, M C 2022, ' Molecular super-gluing : a straightforward tool for antibody labelling and its application to mycotoxin biosensing ', Analytical and Bioanalytical Chemistry, vol. 414, no. 18, pp. 5373-5384 . https://doi.org/10.1007/s00216-021-03841-3
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Mycotoxins are low molecular weight toxic compounds, which can cause severe health problems in animals and humans. Immunoassays allow rapid, simple and cost-effective screening of mycotoxins. Sandwich assays with a direct readout provide great improv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd517e5ec491df7cef2167a810c75283
https://doi.org/10.1007/s00216-021-03841-3

Quantitation of Thyroid Hormone Binding to Anti-Thyroxine Antibody Fab Fragment by Native Mass Spectrometry

Autor: Janne Jänis, Senthil K. Thangaraj, Henri O. Arola, Juha Rouvinen, Antti Tullila, Tarja K. Nevanen

Publikováno v: ACS Omega
Thangaraj, S K, Arola, H, Tullila, A, Nevanen, T K, Rouvinen, J & Jänis, J 2019, ' Quantitation of Thyroid Hormone Binding to Anti-Thyroxine Antibody Fab Fragment by Native Mass Spectrometry ', ACS Omega, vol. 4, no. 20, pp. 18718-18724 . https://doi.org/10.1021/acsomega.9b02659
ACS Omega, Vol 4, Iss 20, Pp 18718-18724 (2019)

Thyroid hormones are important regulatory hormones, acting on nearly every cell in the body. The two main thyroid hormones are l-thyroxine (tetraiodo-l-thyronine, T4) and 3,3′,5-triiodo-l-thyronine (T3), which are produced in the thyroid gland and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d7ca27c03907df613f88931015ae51
https://doi.org/10.1021/acsomega.9b02659