Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Tarja, Ikonen"'
Autor:
Rebecca S Kristeleit, Antoine Italiano, Petri Bono, Giuseppe Curigliano, Analia Azaro, Katriina J Peltola, Pasi Hakulinen, Chris Garratt, Tarja Ikonen, Mika V J Mustonen
Publikováno v:
ESMO Open, Vol 5, Iss 6 (2020)
Background Genetic alterations in fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor receptor (VEGFR) signalling are observed in various tumours. We report a first-in-human phase I/IIa trial evaluating tolerability, pharm
Externí odkaz:
https://doaj.org/article/37210da0f0874e5b851261086f8e9984
Autor:
Pekka J. Kallio, Murali Ramachandra, Nanduri Srinivas, Ravi K. Ujjinamatada, Subhendu Mukherjee, Samiulla Dhodheri, Thomas Anthony, Nagaraj Gowda, Rashmi Nair, Jiju Mani, Raghuveer K. Ramachandra, Kishore Narayanan, Shekar Chelur, Srinivasan Rajagopalan, Susanta Samajdar, Timo Korjamo, Riikka Oksala, Stefan Karlsson, Gerd Wohlfahrt, Tero Linnanen, Mari L. Björkman, Tarja Ikonen, Anu-Maarit Moilanen, Tim H. Holmström
Supplementary table S1 shows the effect of ODM-203 in a large kinase panel. Supplementary figure S1 shows how ODM-203 is synthesized. Supplementary figure S2 shows the effect of ODM-203 on FRS2 phosphorylation. Supplement figure S3 shows the effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a4b40ece62b019671a48c99c70cd8b
https://doi.org/10.1158/1535-7163.22505722
https://doi.org/10.1158/1535-7163.22505722
Autor:
Pekka J. Kallio, Murali Ramachandra, Nanduri Srinivas, Ravi K. Ujjinamatada, Subhendu Mukherjee, Samiulla Dhodheri, Thomas Anthony, Nagaraj Gowda, Rashmi Nair, Jiju Mani, Raghuveer K. Ramachandra, Kishore Narayanan, Shekar Chelur, Srinivasan Rajagopalan, Susanta Samajdar, Timo Korjamo, Riikka Oksala, Stefan Karlsson, Gerd Wohlfahrt, Tero Linnanen, Mari L. Björkman, Tarja Ikonen, Anu-Maarit Moilanen, Tim H. Holmström
Alterations in the gene encoding for the FGFR and upregulation of the VEGFR are found often in cancer, which correlate with disease progression and unfavorable survival. In addition, FGFR and VEGFR signaling synergistically promote tumor angiogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0ba784729eaeca665669c7e27a87040
https://doi.org/10.1158/1535-7163.c.6538162.v1
https://doi.org/10.1158/1535-7163.c.6538162.v1
Autor:
Emmanuel S. Antonarakis, Nicole Zhang, Jayati Saha, Liina Nevalaita, Scott A. Shell, Chris Garratt, Tarja Ikonen, Karim Fizazi
Publikováno v:
Journal of Clinical Oncology. 41:204-204
204 Background: Treatment of men with metastatic castration-resistant prostate cancer (mCRPC) using drugs targeting the AR pathway is hampered by development of resistance including activating AR ligand-binding domain (LBD) point mutations. AR LBD mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61f5e645125e636b2ba4b6d3b582f102
https://doi.org/10.1200/jco.2023.41.6_suppl.204
https://doi.org/10.1200/jco.2023.41.6_suppl.204
Autor:
Alice Bernard-Tessier, Tapio Utriainen, Natalie Cook, Philippe Barthélémy, Nada Lallous, Martin Gleave, Tarja Ikonen, Reetta Riikonen, Pasi Pohjanjousi, Chris Garratt, Karim Fizazi
Publikováno v:
Journal of Clinical Oncology. 40:5057-5057
5057 Background: Activating AR mutations ensure a continued AR activation by non-androgen steroid ligands, e.g. progesterone and glucocorticoids. CYP11A1 is the only enzyme that catalyzes the conversion of cholesterol to pregnenolone, from which all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::131d4440de9d92ba19c3a5cf96ef8a98
https://doi.org/10.1200/jco.2022.40.16_suppl.5057
https://doi.org/10.1200/jco.2022.40.16_suppl.5057
Autor:
Karim Fizazi, Natalie Cook, Philippe Barthélémy, Alice Bernard-Tessier, Capucine Baldini, Niamh Peters, Pirjo Nykänen, Tarja Ikonen, Pasi Pohjanjousi, Leena Mattila, Lauri Jouhi, Annamari Vuorela, Chris Garratt, Tapio Utriainen
Publikováno v:
Journal of Clinical Oncology. 40:18-18
18 Background: ODM-208 is a novel, oral, non-steroidal and selective inhibitor of CYP11A1, the first and rate-limiting enzyme of steroid biosynthesis. ODM-208 suppresses the production of all steroid hormones and their precursors that may activate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dbd862d56815ed3b864e424a6d0f359
https://doi.org/10.1200/jco.2022.40.6_suppl.018
https://doi.org/10.1200/jco.2022.40.6_suppl.018
Autor:
Shekar Chelur, Murali Ramachandra, Samiulla Dhodheri, Stefan Karlsson, Nanduri Srinivas, Thomas Anthony, Nagaraj Gowda, Kishore Narayanan, Tero Linnanen, Raghuveer Ramachandra, Tarja Ikonen, Jiju Mani, Susanta Samajdar, Ravi Kotrabasaiah Ujjinamatada, Srinivasan Rajagopalan, Timo Korjamo, Mari Björkman, Subhendu Mukherjee, Pekka Kallio, Rashmi Nair, Riikka Oksala, Gerd Wohlfahrt, Tim H. Holmström, Anu-Maarit Moilanen
Publikováno v:
Molecular cancer therapeutics. 18(1)
Alterations in the gene encoding for the FGFR and upregulation of the VEGFR are found often in cancer, which correlate with disease progression and unfavorable survival. In addition, FGFR and VEGFR signaling synergistically promote tumor angiogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef7dde209da91f1d77c8d247e665c2b
https://pubmed.ncbi.nlm.nih.gov/30301864
https://pubmed.ncbi.nlm.nih.gov/30301864
Autor:
Reetta Riikonen, Tarja Ikonen, Pekka Kallio, Juha Rantala, Aravind A B, Susanta Samajdar, Mari Björkman, Murali Ramachandra, Elina Mattila, Girish Daginakatte, Mahaboobi Jaleel, Anu-Maarit Moilanen, Chandrasekhar Abbineni, Sivapriya Marappan
Publikováno v:
Cancer Research. 77:118-118
Background: Bromodomain and extra-terminal (BET) family proteins are dual bromodomain-containing epigenetic readers that bind to acetylated-lysine residues at gene promoter and enhancer elements in histones and recruit protein complexes to promote tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41ad629b045cd353dac989ceecb26ac8
https://doi.org/10.1158/1538-7445.am2017-118
https://doi.org/10.1158/1538-7445.am2017-118
Autor:
Jordi Rodon, Chris Garratt, Rebecca Kristeleit, Mika Mustonen, Ulrik Lassen, Christophe Massard, H.-T. Arkenau, Antoine Italiano, K. Peltola, Analia Azaro, Tarja Ikonen, Petri Bono, Pasi Hakulinen
Publikováno v:
Annals of Oncology. 29:viii137-viii138
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a9669fd67d638ac946df038a55868b4
https://doi.org/10.1093/annonc/mdy279.408
https://doi.org/10.1093/annonc/mdy279.408
Autor:
Heli Nevanlinna, Jukka-Pekka Mecklin, Pia Vahteristo, Kaija Holli, Kirsi Syrjäkoski, Peter Lipman, Heikki Järvinen, Sanna Siltanen, Carl Blomqvist, Teuvo L.J. Tammela, Rainer Fagerholm, Joan E. Bailey-Wilson, Lauri A. Aaltonen, Jacob Mallott, Johanna Schleutker, Tarja Ikonen, Kristiina Aittomäki
Publikováno v:
European Journal of Human Genetics. 16:983-991
Recently, a nonsense alteration Trp149Stop in the ARLTS1 gene was found more frequently in familial cancer cases versus sporadic cancer patients and healthy controls. Here, the role of Trp149Stop or any other ARLTS1 germline variant was evaluated on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705edcf4cfb19cded3ffb60a66b36660
https://doi.org/10.1038/ejhg.2008.43
https://doi.org/10.1038/ejhg.2008.43