Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Tariq Hussain Khan"'
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 9:717-727
Metastatic malignant melanoma remains a highly aggressive form of skin cancer for which no reliable methods for treatment exist. Given the increasing incidence of this cancer, considerable attention has focused on the development of new and improved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5decb4d8d7ee0b16948890ad29b98da
https://doi.org/10.2174/187152009789056886
https://doi.org/10.2174/187152009789056886
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:2625-2633
The suitability of 4-di(2-chloroethyl)aminoanilino-4-hydroxyphenethylaminomethanone 2 to act as a prodrug for melanocyte-directed enzyme prodrug therapy (MDEPT) is assessed. Thus its synthesis, ability to generate a cytotoxic agent upon exposure to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5fbcbee8c7adbce87b815a54b52f8c1
https://doi.org/10.1016/s0968-0896(02)00097-4
https://doi.org/10.1016/s0968-0896(02)00097-4
Autor:
Helen M. I. Osborn, Hugh Malkin, Andrew Photiou, Allan M. Jordan, Tariq Hussain Khan, Patrick A. Riley
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:1549-1558
Evaluation of second generation prodrugs for MDEPT, by oximetry, has highlighted structural properties that are advantageous and disadvantageous for efficient oxidation using mushroom tyrosinase. In particular, a sterically undemanding prodrug bis-(2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fec479b4e3e267662582f8595357e24
https://doi.org/10.1016/s0968-0896(01)00039-6
https://doi.org/10.1016/s0968-0896(01)00039-6
Autor:
Frances Searle, Pat J. Browne, Tariq Hussain Khan, Ebun A. Eno-Amooquaye, Helen M. I. Osborn, Philip J. Burke
Publikováno v:
Journal of Medicinal Chemistry. 42:951-956
The design and synthesis of potent thiocarbamate inhibitors for carboxypeptidase G2 are described. The best thiocarbamate inhibitor N-(p-methoxybenzenethiocarbonyl)amino-L-glutamic acid 6d, chosen for preliminary investigations of in vitro antibody-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a896bdfd87cb31d36da344d3c0fd85
https://doi.org/10.1021/jm990004i
https://doi.org/10.1021/jm990004i
Autor:
Tariq Hussain Khan, Helen M. I. Osborn
Publikováno v:
Tetrahedron. 55:1807-1850
A review of methods available for the polymer supported syntheses of oligosaccharides and glycopeptides is presented. The range of polymers and linkers, oligosaccharide assembly strategies, and analytical techniques employed in recent syntheses are d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27eaf642d57ecd7576d63c5bd739188f
https://doi.org/10.1016/s0040-4020(98)01200-9
https://doi.org/10.1016/s0040-4020(98)01200-9
Autor:
Helen M. I. Osborn, Tariq Hussain Khan
Publikováno v:
ChemInform. 30
A review of methods available for the polymer supported syntheses of oligosaccharides and glycopeptides is presented. The range of polymers and linkers, oligosaccharide assembly strategies, and analytical techniques employed in recent syntheses are d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eface23b88d749fa40b195295aa665d7
https://doi.org/10.1002/chin.199924256
https://doi.org/10.1002/chin.199924256