Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Tariq E. Khoyratty"'
Autor:
Marco Bo, Magdalena Niegowska, Hayley L. Eames, Hannah Almuttaqi, Giannina Arru, Gian Luca Erre, Giuseppe Passiu, Tariq E. Khoyratty, Erinke van Grinsven, Irina A. Udalova, Leonardo A. Sechi
Publikováno v:
Journal of Translational Autoimmunity, Vol 3, Iss , Pp 100048- (2020)
Background: Improved knowledge of different biomarkers is crucial for early diagnosis of rheumatic diseases and to provide important insights for clinical management. In this study, we evaluated the seroreactivity of patients with different connectiv
Externí odkaz:
https://doaj.org/article/73914dab07394054811cad61d6eb6675
Autor:
Tariq E. Khoyratty, Bin Xie, Gabriela Pirgova, Tal I. Arnon, Enas Abu-Shah, Andrew J. MacLean, Michael L. Dustin, Zhiyuan Hu, Pablo F. Céspedes, Ahmed Ashour Ahmed, Irina A. Udalova
Publikováno v:
The Journal of Immunology Author Choice
Key Points The Zinc finger protein, Zbtb18, is downregulated during PC differentiation. Enhanced expression of Zbtb18 leads to impaired PC development. Zbtb18 directly binds and inhibits expression of PI3K subunits.
The PI3K pathway plays a key
The PI3K pathway plays a key
Autor:
Poonam Ghai, Adam J. Byrne, Tariq E. Khoyratty, Irina A. Udalova, Peter McErlean, J Iwasaki, Clare M. Lloyd, Gesa J. Albers, Patricia P. Ogger
Publikováno v:
Clinical and Experimental Immunology
Summary Interferon regulatory factor 5 (IRF5) is a master regulator of macrophage phenotype and a key transcription factor involved in expression of proinflammatory cytokine responses to microbial and viral infection. Here, we show that IRF5 controls
Autor:
Kristina Zec, Roman Fischer, Irina A. Udalova, Tariq E. Khoyratty, Claire Pearson, Hayley L. Eames, Benedikt M. Kessler, Hannah Almuttaqi, Grigory Ryzhakov, Simon Travis, Samuel J. Bullers, Luke Jostins-Dean, Alastair L. Corbin, Sarah Bonham, Zhichao Ai, Dorothée L. Berthold
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Interferon regulating factor 5 (IRF5) is a multifunctional regulator of immune responses, and has a key pathogenic function in gut inflammation, but how IRF5 is modulated is still unclear. Having performed a kinase inhibitor library screening in macr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8cfb57ebeee917922ddd5935776e62
https://doi.org/10.1038/s41467-021-27038-5
https://doi.org/10.1038/s41467-021-27038-5
Autor:
Ritu Arya, Tariq E. Khoyratty, Jade Bailey, Hector Gallart-Ayala, Mihai G. Netea, Ricardo Carnicer, André F. Rendeiro, Craig E. Wheelock, Robin P. Choudhury, Thomas Krausgruber, Irina A. Udalova, Klemen Ziberna, Alastair L. Corbin, Jurga Laurencikiene, Mark J. Crabtree, Thomas J. Cahill, Naveed Akbar, Adam Braithwaite, Joshua T. Chai, Madeleine E. Lemieux, Mikael Rydén, Laurienne Edgar, Christoph Bock, Keith M. Channon, Mohammad Alkhalil, Niels P. Riksen
Publikováno v:
Circulation, 144, 12, pp. 961-982
Circulation
Circulation, 144, 961-982
Circulation
Circulation, 144, 961-982
Supplemental Digital Content is available in the text.
Background: Cardiovascular risk in diabetes remains elevated despite glucose-lowering therapies. We hypothesized that hyperglycemia induces trained immunity in macrophages, promoting persist
Background: Cardiovascular risk in diabetes remains elevated despite glucose-lowering therapies. We hypothesized that hyperglycemia induces trained immunity in macrophages, promoting persist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c702e6678b0b9843a3ed29fda41cc2
https://repository.ubn.ru.nl/handle/2066/238017
https://repository.ubn.ru.nl/handle/2066/238017
Autor:
Annette Zehrer, Ashleigh Hemmings, Erinke van Grinsven, Sara A. Mathie, Tariq E. Khoyratty, Lihui Wang, Zhichao Ai, Nicola Willemsen, Irina A. Udalova, Iván Ballesteros, Andrés Hidalgo, Hayley L. Eames, Barbara Walzog, Valentin von Werz, Sandra Martín-Salamanca
Publikováno v:
Nature immunology. 22(9)
Neutrophils display distinct gene expression patters depending on their developmental stage, activation state and tissue microenvironment. To determine the transcription factor networks that shape these responses in a mouse model, we integrated trans
Autor:
Claudia Monaco, Raashid Luqmani, Kristina Zec, Susan J. Morris, Tariq E. Khoyratty, Alison Hudak, Lihui Wang, Irina A. Udalova, Erinke van Grinsven, Hayley L. Eames, David Ahern, Zhichao Ai, Evgeniy Eruslanov
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 20 (2020)
JCI Insight, Vol 5, Iss 20 (2020)
Giant cell arteritis (GCA) is a common form of primary systemic vasculitis in adults, with no reliable indicators of prognosis or treatment responses. We used single cell technologies to comprehensively map immune cell populations in the blood of pat
Autor:
Hayley L. Eames, Alastair L. Corbin, Grigory Ryzhakov, Hannah Almuttaqi, Zhichao Ai, Samuel J. Bullers, Dorothée L. Berthold, Simon Travis, Benedikt M. Kessler, Tariq E. Khoyratty, Roman Fischer, Irina A. Udalova, Luke Jostins-Dean, Sarah Bonham
Inflammatory bowel disease (IBD) is a group of inflammatory disorders of the gastro-intestinal tract caused by a complex combination of genetic and environmental factors. Interferon regulating factor 5 (IRF5) is a multifunctional regulator of immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53eb597b4bc265c4753ba90752c274f6
https://doi.org/10.1101/2020.05.24.113076
https://doi.org/10.1101/2020.05.24.113076
Autor:
Gabriel Fernández-Calvo, Florent Ginhoux, Ana Dopazo, Tommaso Vicanolo, Erinke van Grinsven, Eleonora Lusito, Estanislao Nistal-Villán, José M. Adrover, Iván Ballesteros, Giulia Barbiera, Sara González-Hernández, Alberto Benguria, Renato Ostuni, Francisco Mayo, Sandra Martín-Salamanca, Antonio Maccataio, Christian Schulz, Stefanie Ascher, Marco Genua, Juan A. Quintana, Lai Guan Ng, Tariq E. Khoyratty, Fátima Sánchez-Cabo, Irina A. Udalova, Andrés Hidalgo, Alejandra Aroca-Crevillen, Immanuel Kwok, Jackson LiangYao Li, Andrea Rubio-Ponce, Christoph Reinhardt, José Ángel Nicolás-Ávila, Matthias Gunzer, Oliver Soehnlein
Publikováno v:
Cell
Classically considered short-lived and purely defensive leukocytes, neutrophils are unique in their fast and moldable response to stimulation. This plastic behavior may underlie variable and even antagonistic functions during inflammation or cancer,
Autor:
Stephen N. Sansom, Tariq E. Khoyratty, Moustafa Attar, Alastair L. Corbin, Isabelle C. Arnold, Dorothée L. Berthold, Irina A. Udalova, Fiona Powrie, M Gomez-Vazquez, Hannah Almuttaqi
Mononuclear phagocytes (MNPs) play a key role in maintaining intestinal homeostasis but also in triggering immunopathology in response to acute microbial stimulation, which induces the recruitment of masses of Ly6Chimonocytes to the gut. The regulato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89f0ff78e3771dbb17b664588a00c31
https://doi.org/10.1101/601963
https://doi.org/10.1101/601963