Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Tariq E. Farrah"'
Autor:
Tariq E. Farrah, Dan Pugh, Fiona A. Chapman, Emily Godden, Craig Balmforth, Gabriel C. Oniscu, David J. Webb, Baljean Dhillon, James W. Dear, Matthew A. Bailey, Peter J. Gallacher, Neeraj Dhaun
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract In patients with chronic kidney disease (CKD), there is an unmet need for novel biomarkers that reliably track kidney injury, demonstrate treatment-response, and predict outcomes. Here, we investigate the potential of retinal optical coheren
Externí odkaz:
https://doaj.org/article/c6fc4eec224e416b98d9113a9b9e3588
Autor:
Kathleen M. Scullion, A. D. Bastiaan Vliegenthart, Laura Rivoli, Wilna Oosthuyzen, Tariq E. Farrah, Alicja Czopek, David J. Webb, Robert W. Hunter, Matthew A. Bailey, Neeraj Dhaun, James W. Dear
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101937- (2021)
Summary: Vascular and kidney dysfunction commonly co-exist. There is a need for biomarkers of vascular health. Circulating microRNAs are biomarkers; miR-126 is endothelial cell-enriched. We measured circulating miR-126 in rats with nephrotoxic nephri
Externí odkaz:
https://doaj.org/article/be8bdfd2958a4679a313fe5958f85e1c
Autor:
Tariq E. Farrah, Vanessa Melville, Alicja Czopek, Henry Fok, Lorraine Bruce, Nicholas L. Mills, Matthew A. Bailey, David J. Webb, James W. Dear, Neeraj Dhaun
Publikováno v:
Farrah, T E, Melville, V, Czopek, A, Fok, H, Bruce, L, Mills, N L, Bailey, M A, Webb, D J, Dear, J W & Dhaun, N 2022, ' Arterial stiffness, endothelial dysfunction and impaired fibrinolysis are pathogenic mechanisms contributing to cardiovascular risk in ANCA-associated vasculitis ', Kidney International, vol. 102, pp. 1115-1126 . https://doi.org/10.1016/j.kint.2022.07.026
Cardiovascular disease is a complication of systemic inflammatory diseases and anti-neutrophil cytoplasm antibody-associated vasculitis (AAV) is an exemplar. Mechanisms are poorly understood, and risk-reduction strategies are lacking.In a series of d
Autor:
Ylenia Giarratano, Dan Pugh, Tariq E. Farrah, Gabriel C. Oniscu, Thomas J. MacGillivray, Baljean Dhillon, Neeraj Dhaun, Miguel O. Bernabeu
Publikováno v:
Giarratano, Y, Pugh, D, Farrah, T, Oniscu, G, MacGillivray, T J, Dhillon, B, Dhaun, N & Bernabeu, M O 2022, ' Novel retinal vascular phenotypes for the potential assessment of long-term risk in living kidney donors ', Kidney International, vol. 102, no. 3, pp. 661-665 . https://doi.org/10.1016/j.kint.2022.06.019
Autor:
Alicja Czopek, Rebecca Moorhouse, Peter J. Gallacher, Dan Pugh, Jessica R. Ivy, Tariq E. Farrah, Emily Godden, Robert W. Hunter, David J. Webb, Pierre-Louis Tharaux, David C. Kluth, James W. Dear, Matthew A. Bailey, Neeraj Dhaun
Publikováno v:
Science Translational Medicine. 14
Acute kidney injury (AKI) is common and associated with increased risks of cardiovascular and chronic kidney disease. Causative molecular/physiological pathways are poorly defined. There are no therapies to improve long-term outcomes. An activated en
Autor:
Fiona J Gifford, Francesca Moroni, Tariq E Farrah, Kirstie Hetherington, Tom J MacGillivray, Peter C Hayes, Neeraj Dhaun, Jonathan A Fallowfield
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 10, p 3332 (2020)
Microcirculatory dysfunction is associated with organ failure, poor response to vasoactive drugs and increased mortality in cirrhosis, but monitoring techniques are not established. We hypothesized that the chorioretinal structures of the eye could b
Externí odkaz:
https://doaj.org/article/fea86619c6d74a64a8915e33c53abca4
Autor:
Vanessa Melville, Nicola C. Edwards, Richard P. Steeds, Thomas F. Hiemstra, Anna S Herrey, Samir Mehta, Iain M. MacIntyre, Jonathan N. Townend, Amreen Kaur, Anna M Price, Tariq E. Farrah, Peter J. Greasley, Natalie Ives, Ian B. Wilkinson, David C. Wheeler, Rebekah Wale, Charles J. Ferro, Neeraj Dhaun, David J. Webb, Gemma Slinn
Publikováno v:
Edwards, N C, Price, A M, Mehta, S, Hiemstra, T F, Kaur, A, Greasley, P J, Webb, D J, Dhaun, N, MacIntyre, I M, Farrah, T, Melville, V, Herrey, A, Slinn, G, Wale, R, Ives, N, Wheeler, D C, Wilkinson, I, Steeds, R P, Ferro, C J & Townend, J N 2021, ' Effects of Spironolactone and Chlorthalidone on Cardiovascular Structure and Function in Chronic Kidney Disease : A Randomized, Open-Label Trial ', Clinical Journal of the American Society of Nephrology . https://doi.org/10.2215/CJN.01930221
Clin J Am Soc Nephrol
Clin J Am Soc Nephrol
Background and objectives In a randomized double-blind, placebo-controlled trial, treatment with spironolactone in early-stage CKD reduced left ventricular mass and arterial stiffness compared with placebo. It is not known if these effects were due t
Autor:
Iain M. MacIntyre, Emma J. Turtle, Tariq E. Farrah, Catriona Graham, James W. Dear, David J. Webb, Morag McCallum, Vanessa Melville, Henry Fok, Jame C. McCrae, Ashish Sule, Thomas M. Caparrotta, Nicholas S. Kirkby, Jane A. Mitchell
Publikováno v:
Circulation
MacIntyre, I, Turtle, E J, Farrah, T E, Graham, C, Dear, J W, Webb, D J & Melville, V & Caparrotta, T M 2022, ' Regular acetaminophen use and blood pressure in people with hypertension The PATH-BP Trial ', Circulation . https://doi.org/10.1161/CIRCULATIONAHA.121.056015
MacIntyre, I, Turtle, E J, Farrah, T E, Graham, C, Dear, J W, Webb, D J & Melville, V & Caparrotta, T M 2022, ' Regular acetaminophen use and blood pressure in people with hypertension The PATH-BP Trial ', Circulation . https://doi.org/10.1161/CIRCULATIONAHA.121.056015
Background: Acetaminophen is widely used as first-line therapy for chronic pain because of its perceived safety and the assumption that, unlike nonsteroidal anti-inflammatory drugs, it has little or no effect on blood pressure (BP). Although observat
Publikováno v:
Kidney International
Farrah, T, Dhillon, B, Keane, P A, Webb, D & Dhaun, N 2020, ' The eye, the kidney & cardiovascular disease: old concepts, better tools & new horizons ', Kidney International . https://doi.org/10.1016/j.kint.2020.01.039
Farrah, T, Dhillon, B, Keane, P A, Webb, D & Dhaun, N 2020, ' The eye, the kidney & cardiovascular disease: old concepts, better tools & new horizons ', Kidney International . https://doi.org/10.1016/j.kint.2020.01.039
Chronic kidney disease (CKD) is common, with hypertension and diabetes mellitus acting as major risk factors for its development. Cardiovascular disease is the leading cause of death worldwide and the most frequent end point of CKD. There is an urgen
Publikováno v:
British Journal of Pharmacology
PDE type 5 inhibitors (PDE5Is), such as sildenafil, tadalafil and vardenafil, are a class of drugs used to prolong the physiological effects of NO/cGMP signalling in tissues through the inhibition of cGMP degradation. Although these agents were origi