Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Tariq Arshad"'
Autor:
Ahmed Abdullah Ahmed, Shuang Chen, Maria Roman-Escorza, Richard Angell, Sally Oxenford, Matthew McConville, Naomi Barton, Mihiro Sunose, Dan Neidle, Shozeb Haider, Tariq Arshad, Stephen Neidle
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The tetrasubstituted naphthalene diimide compound QN-302 binds to G-quadruplex (G4) DNA structures. It shows high potency in pancreatic ductal adenocarcinoma (PDAC) cells and inhibits the transcription of cancer-related genes in these cells
Externí odkaz:
https://doaj.org/article/6e2ed99e2cc7475b8ea3594c22ec910c
Autor:
Ahmed A. Ahmed, William Greenhalf, Daniel H. Palmer, Nicole Williams, Jenny Worthington, Tariq Arshad, Shozeb Haider, Effrosyni Alexandrou, Dilek Guneri, Zoe A. E. Waller, Stephen Neidle
Publikováno v:
Molecules, Vol 28, Iss 6, p 2452 (2023)
The naphthalene diimide compound QN-302, designed to bind to G-quadruplex DNA sequences within the promoter regions of cancer-related genes, has high anti-proliferative activity in pancreatic cancer cell lines and anti-tumor activity in several exper
Externí odkaz:
https://doaj.org/article/591626fbac0d4eabb244b440fd15c9c6
Publikováno v:
Soft Computing for Problem Solving ISBN: 9789811965241
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38c86a59ed7e61ba4219b2123f4f451d
https://doi.org/10.1007/978-981-19-6525-8_10
https://doi.org/10.1007/978-981-19-6525-8_10
Autor:
Geoff Clarke, Howard Donninger, Raphael Jigo, Tariq Arshad, Becca von Baby, Rachel Ferrill, Mike Sabo, Joe Burlison, John Trent
Publikováno v:
Molecular Cancer Research. 21:B005-B005
Since RAS mutations are rare in Breast Cancer, RAS has not traditionally been considered as an important driver of this disease. However, RAS signaling pathways are frequently hyper-activated in breast cancers and genetic/epigenetic inactivation of R
Autor:
Geoff Clarke, Tariq Arshad, Howard Donninger, Becca von Baby, Rachel Ferrill, Mike Sabo, Joe Burlison, John Trent
Publikováno v:
Molecular Cancer Research. 21:B006-B006
RAS oncogenes are frequently activated by mutations in pancreatic and lung cancer, where they appear to act as driving mutations. This study examines the activity of a series of novel direct RAS inhibitors with a predicted unique interaction region.
Publikováno v:
Cancer Research. 83:4981-4981
The compound QN-302, a tetra-substituted naphthalene diimide (ND) derivative has been designed to have high affinity for G-quadruplex (G4) nucleic acids. It has single-digit nM anti-proliferative activity in a panel of human pancreatic cancer cell li
Publikováno v:
Cancer Research. 83:390-390
The compound QN-302, a tetra-substituted naphthalene diimide (ND) derivative has been designed as a potent compound for targeting quadruplex sequences in cancer genes. It has single-digit nM anti-proliferative activity in a panel of human pancreatic
Publikováno v:
Cancer Research. 83:2708-2708
Introduction and Purpose: Triple-negative breast cancer (TNBC) accounts for 12% of breast cancers (BC) in the US and 15% worldwide. It lacks expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor recep
Autor:
Scott J. Bornheimer, Julie Berube, Wei Huang, Maurice R.G. O'Gorman, Michelle McNamara, Marsha Hartman, Suraj Saksena, Tariq Arshad
Publikováno v:
Cytometry
Cytometry Part A
Cytometry Part A
A reduced peripheral blood absolute lymphocyte count with an elevated neutrophil count has been a consistent observation in hospitalized coronavirus disease 2019 (COVID-19) patients. In this brief meta-analysis, the reduction of lymphocyte subset cou
Publikováno v:
Cancer Research. 82:A079-A079
The human genome contains multiple sites of quadruplex (G4) arrangements, with over-representation in promoter regions of many oncogenes. Small molecule G4 stabilization down-regulates the transcription of these genes, leading to selective inhibition