Analysis of mutations in precision oncology using the automated, accurate, and user-friendly web tool PredictONCO

Autor: Rayyan Tariq Khan, Petra Pokorna, Jan Stourac, Simeon Borko, Adam Dobias, Joan Planas-Iglesias, Stanislav Mazurenko, Ihor Arefiev, Gaspar Pinto, Veronika Szotkowska, Jaroslav Sterba, Jiri Damborsky, Ondrej Slaby, David Bednar

Publikováno v: Computational and Structural Biotechnology Journal, Vol 24, Iss , Pp 734-738 (2024)

Next-generation sequencing technology has created many new opportunities for clinical diagnostics, but it faces the challenge of functional annotation of identified mutations. Various algorithms have been developed to predict the impact of missense v

Externí odkaz: https://doaj.org/article/3d4ec3367bee4e13870e203cd22157b5

A computational workflow for analysis of missense mutations in precision oncology

Autor: Rayyan Tariq Khan, Petra Pokorna, Jan Stourac, Simeon Borko, Ihor Arefiev, Joan Planas-Iglesias, Adam Dobias, Gaspar Pinto, Veronika Szotkowska, Jaroslav Sterba, Ondrej Slaby, Jiri Damborsky, Stanislav Mazurenko, David Bednar

Publikováno v: Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-10 (2024)

Abstract Every year, more than 19 million cancer cases are diagnosed, and this number continues to increase annually. Since standard treatment options have varying success rates for different types of cancer, understanding the biology of an individua

Externí odkaz: https://doaj.org/article/138a77a9475c4a66973983bff91f0986

Synthesis, characterization, and molecular docking studies of novel hippuric acid anhydrides as potential antiurolithic, analgesic and free radical scavenging agents

Autor: Zahid Munawar, Kashif ur Rehman Khan, Humaira Nadeem, Saeed Ahmad, M Yasmin Begum, Ayesha Siddiqua, Huma Rao, Muhammad Tariq Khan

Publikováno v: Journal of Saudi Chemical Society, Vol 28, Iss 5, Pp 101902- (2024)

Hippuric acid is a biotransformation product in humans which is excreted through urine. Dietary intake of phenolic compounds increases its concentration in urine. Hippuric acid is experimentally proved to be a regulator of calcium oxalate super satur

Externí odkaz: https://doaj.org/article/6978b5f576b046cf8ac21922ae38c391

Cost-effectiveness of craniotomy versus decompressive craniectomy for UK patients with traumatic acute subdural haematoma

Autor: Emma Toman, David K Menon, Antonio Belli, Sridevi Nagarajan, Julie Woodfield, Ruichong Ma, Jason J Chang, Jonathan Cook, Mark Kotter, Vin Shen Ban, Martin Smith, John D Pickard, Diederik Bulters, Giles Critchley, Damian Holliman, Nicole Keong, Andrew King, Catherine McMahon, Carole Turner, Peter Whitfield, Mark Wilson, Melvin Stone, Paul Brennan, David Turner, Garry Barton, Rasheed Zakaria, Angelos G Kolias, Simon Shaw, Sean Christie, Dmitri Shastin, Allison Hirst, Soumya Mukherjee, Gareth Roberts, Simon Thomson, Peter J Hutchinson, Alexis Joannides, Emanuel Cirstea, Ashish Bindra, Vairavan Narayanan, David Menon, Francesca Hill, Ashwin Kumaria, Franco Servadei, Rhys Thomas, Midhun Mohan, Silvia Tarantino, Ioana Moldovan, Sara Venturini, Tariq Khan, Marianne Hare, Louise Young, Joan Grieve, Ardalan Zolnourian, Paula Carroll, Diederik Oliver Bulters, Mathew Guilfoyle, Lisa Julien, Barbara Gregson, Martin Hunn, Richard Nelson, Stuart Smith, Shahid Khan, András Büki, Deepak Gupta, Christos Tolias, David A Turner, Christopher Madden, Paul Johnston, Peter John Hutchinson, Patrick Holton, Panagiota Gkolia, Nicola Owen, Kesava Reddy, Hani Marcus, Ibrahim Jalloh, Shabin Joshi, Ian Anderson, Himanshu Shekhar, Daniel Holsgrove, Erin Lewis, Tracey Moore, Marios C Papadopoulos, Paula Kareclas, Peter Kirkpatrick, Laura Parker, Martina Stippler, Sarah Pyne, Peter J Kirkpatrick, James Piercy, Neil Davidson, Prasanna Epaliyanage, Barbara A Gregson, Christopher Uff, Malik Zaben, Charlotte Eglinton, Linetty Makawa, Jane Perez, Louise Harrison, Mutwakil Abdulla, Garry R Barton, Mathew Joseph, Anthony Bell, Sarah Trippier, Michael Canty, Jonathan Pollock, Manjul Tripathi, Harry Mee, Ivan Timofeev, Ellie Edlmann, Nadia Scantlebury, Joseph Frantzias, Yahia Al-Tamimi, Kismet Hossain-Ibrahim, Ciaran Hill, Elisa Visentin, Sonia Raj, Ioannis Fouyas, Siobhan Kearney, Karen Caldwell, Tamara Tajsic, Belinda Gunning, Emma Clarkson, Manjunath Prasad, Mary Kambafwile, Tim Lawrence, Emily Galea, Sebastian Ille, Hadie Adams, Shumaila Hasan, Matthew G Stovell, Edoardo Viaroli, Adel E Helmy, Ivan S Timofeev, Kirsty Grieve, Liz Corteen, Janet Corn, Mohammad Naushahi, Richard Mair, Kamila Walker, Selma Tülü, Chipo Chitsenega, Geetha Boyapati, Muhammad Bhatti, Natalia Ermalai, Joseph Merola Liudmila, Laurence Glanz, Lani Patterson, Colin Bergin, Maximina Ventura, Laura Ortiz-Ruiz de Gordoa, Husam Georges, Sam Jeffrey, Natasha Wilmhurst, Philip Kane, Geraint Sunderland, John Kitchen, Mathew JosephMathew JosephGallagher, Sonia Fernandez Lopez, Andrea D’Mello, Jo-Anna Conyngham, Miriam Taylor, Charlaine Reeve, Vasileios Arzoglou, Arif Zafar, Efosa Ukponmwan, Anastasios Giamouriadis, Adam Wahba, Patrick Easton, Rose Clegg, Grace Cole, Louise Finlay, Alex Leggate, Terrie-Louise Cromie, Javier Magan Ventura, Ruth Womer, Beverley Fulkner, Geraldine Ward, Kareen Damley, Emma Fleming, Roddy O’Kane, Indira Devi Bhagavatula, Dhananjaya Ishwar Bhat, Dhaval Prem Shukla, Kanti Konar, Nagesh Shanhag, Vaishali Nl Valluri, Manoj Kumar Tewari, Kaveri Sharma, Christine Lock, Chen Min Wei, Julian Han, Janell Kwok, Nicolas Kon, Kam King, Emmalin Nelton, Louis Anthony Whitworth, Sonja Stutzman, Caryn Harper, Alice Salazar, Rocco Armonda, George B Moses, Patricia Tanjucto, Jamie Ullman, Orseola Arapi, Betsy Moclair, Nrupen Baxi, John Adair Prall, Meghan Baldwin, Jamie Jones, Clare Gallagher, Ish Bains, Leodante Da Costa, Fahad Alkherayf, Rafael Ochoa Sanchez, Kostas Fountas, Thanasis Paschalis, Sandro Krieg, Maria Luisa, Gandia Gomez, Alfonso Legares, Ana Maria Castaño Leon, Gábor Lenzsér, Mukhtar Khan, Massimo Tomei, Ronie Romelean Jayapalan, Sarah C Pyne, A David Mendelow, Christopher Cowie, Carol Davis-Wilkie, Tapiwa Tungamirai, Kerstin Wolf, Natalia Igosheva, Alicia Gore, Michele Jillings, Christopher Bushell, Peter McCabe

Publikováno v: BMJ Open, Vol 14, Iss 6 (2024)

Objective To estimate the cost-effectiveness of craniotomy, compared with decompressive craniectomy (DC) in UK patients undergoing evacuation of acute subdural haematoma (ASDH).Design Economic evaluation undertaken using health resource use and outco

Externí odkaz: https://doaj.org/article/42e2c9e0dc6e45be90a762e1f99bfb8e

An international, prospective observational study on traumatic brain injury epidemiology study protocol: GEO-TBI: Incidence [version 2; peer review: 2 approved]

Autor: David Clark, Tommi Kalevi Korhonen, Sara Venturini, Sujit Gnanakumar, Thomas Bashford, Midhun Mohan, Indira Devi Bhagavatula, Ronnie Baticulon, Rocío Fernández-Méndez, Ignatius Esene, Deepak Gupta, Anthony Figaji, Tsegazeab Laeke, Tariq Khan, David Menon, Michael Martin, Kee B. Park, Wellingson Paiva, Andres M. Rubiano, Jogi V. Pattisapu, Hamisi Shabani, Vijaya Sekhar, Davi Solla, Kachinga Sichizya, Manjul Tripathi, Abenezer Tirsit, Bart Depreitere, Carole Turner, Laura Lippa, Corrado Iaccarino, Gail Rosseau, Andrew Reisner, Rikin Trivedi, Franco Servadei, Angelos Kolias, Vicknes Waran, Peter Hutchinson, Alexis Joannides

Publikováno v: NIHR Open Research, Vol 3 (2024)

Background The epidemiology of traumatic brain injury (TBI) is unclear – it is estimated to affect 27–69 million individuals yearly with the bulk of the TBI burden in low-to-middle income countries (LMICs). Research has highlighted significant be

Externí odkaz: https://doaj.org/article/04f4d68bdd8b49b9b88be758d48e8675