Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tarikere Gururaja"'
Autor:
Yonchu Jenkins, Tian-Qiang Sun, Vadim Markovtsov, Marc Foretz, Wei Li, Henry Nguyen, Yingwu Li, Alison Pan, Gerald Uy, Lisa Gross, Kristen Baltgalvis, Stephanie L Yung, Tarikere Gururaja, Taisei Kinoshita, Alexander Owyang, Ira J Smith, Kelly McCaughey, Kathy White, Guillermo Godinez, Raniel Alcantara, Carmen Choy, Hong Ren, Rachel Basile, David J Sweeny, Xiang Xu, Sarkiz D Issakani, David C Carroll, Dane A Goff, Simon J Shaw, Rajinder Singh, Laszlo G Boros, Marc-André Laplante, Bruno Marcotte, Rita Kohen, Benoit Viollet, André Marette, Donald G Payan, Todd M Kinsella, Yasumichi Hitoshi
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81870 (2013)
Modulation of mitochondrial function through inhibiting respiratory complex I activates a key sensor of cellular energy status, the 5'-AMP-activated protein kinase (AMPK). Activation of AMPK results in the mobilization of nutrient uptake and cataboli
Externí odkaz:
https://doaj.org/article/9f3bbe0f39b0498d932c53dbf27c0985
Autor:
Ann Rowley, Brian S. Brown, Mary Stofega, Hana Hoh, Rebecca Mathew, Violeta Marin, Rong-Xian Ding, Ryan A. McClure, Fabiola M. Bittencourt, Jun Chen, Tarikere Gururaja, Taisei Kinoshita, Xueqing Wang, Alexey Rivkin, Kevin R. Woller
Publikováno v:
ACS Chemical Biology. 17:1315-1320
Interleukin-1 receptor-associated kinase 3 (IRAK3) is a pseudokinase mediator in the human inflammatory pathway, and ablation of its function is associated with enhanced antitumor immunity. Traditionally, pseudokinases have eluded "druggability" and
Autor:
Ann Mongan, Ronald J. Hill, Melissa Hopper, Taisei Kinoshita, Tarikere Gururaja, James P. Dean
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 372:331-338
Kinases form an attractive class of targets for small molecule inhibitors, but similarity among their adenosine triphosphate binding sites presents difficulties for developing selective drugs. Standard methods of evaluating selectivity of most revers
Autor:
Senthilnathan Palaniyandi, Ethan Strattan, Reena Kumari, Natalya Hakim, Melissa Kesler, Mutiah Apatira, Fabiola Bittencourt, Longcheng Wang, Zhaozhong Jia, Tarikere Gururaja, Ronald Hill, Gerhard C. Hildebrandt
Publikováno v:
Transplantation and Cellular Therapy. 28:S279-S280
Autor:
Juthamas Sukbuntherng, Taisei Kinoshita, Betty Chang, Jun Chen, Daniel Lu, Matthias Versele, Jennifer Whang, Tarikere Gururaja, Danelle F. James
Publikováno v:
European journal of haematology.
Objectives Bruton's tyrosine kinase (BTK) and tyrosine kinase expressed in hepatocellular carcinoma (TEC) are expressed by human platelets. These kinases participate in platelet activation through the collagen receptor glycoprotein VI and may perform
Autor:
Todd Kinsella, Scott K. Powers, Kathy White, Taisei Kinoshita, Tarikere Gururaja, George C. Yam, Kurt J. Sollanek, Donald G. Payan, Vanessa Taylor, John McLaughlin, Wayne Lang, Rongxian Ding, Baljit K. Singh, Mark D. Claypool, Marina Gelman, Derek Hansen, Ira J. Smith, Stephanie Yung, Ashley J. Smuder, Yan Chen, Kelly McCaughey, Raniel Alcantara, Wei Li, Rajinder Singh, Oh Sung Kwon, Guillermo Godinez, Jason Romero, Michael P. Wiggs, Esteban Masuda, Henry N. Nguyen, Annabelle M. Friera, Melissa S. Ho, Kristen Baltgalvis, Daniel P. Creger
Publikováno v:
The FASEB Journal
Controlled mechanical ventilation (CMV) is associated with the development of diaphragm atrophy and contractile dysfunction, and respiratory muscle weakness is thought to contribute significantly to delayed weaning of patients. Therefore, therapeutic
Autor:
Arvinder Sran, Kunbin Qu, Sambaiah Thota, David L. Carroll, Sacha Holland, Tarikere Gururaja, Christian Franci, Vanessa Taylor, D. Wayne Lang, Yonchu Jenkins, Rajinder Singh, George Clemens, Muhammad Baluom, Caroline M. R. Low, Elliott B. Grossbard, Steve Wong, Taisei Kinoshita, Donald G. Payan, Joe Lasaga, John R. McLaughlin, Ankush Argade, Angela Romane, Yanhong Zhu, Betty Chang, David J. Sweeny, Hui Li, Weiduan Xu, Yasumichi Hitoshi, Manjeet Parmer, Polly Pine, Vadim Markovtsov, Feifei Zhao, Erlina Pali, Marina Gelman
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 136:99-113
Aurora kinases play a key role in mitotic progression. Over-expression of Aurora kinases is found in several human cancers and correlated with histological malignancy and clinical outcomes. Therefore, Aurora kinase inhibitors should be useful in the
Autor:
Bernd O. Keller, D. C. Anderson, Jing Zheng, Donald G. Payan, Susan Catalano, Jorge Vialard, Liang Li, Jakob Maria Bogenberger, Michel Janicot, Weiqun Li, Yasumichi Hitoshi, Tarikere Gururaja
Publikováno v:
Chemistry & Biology. 10:927-937
Three nuclear-excluded antiproliferative peptides discovered in an intracellular peptide library screen contained variants of a leucine-rich nuclear exclusion motif. When tagged with N-terminal lys 7 , two peptides, but not quadruple alanine motif mu
Publikováno v:
Journal of Protein Chemistry. 20:507-519
Green fluorescent protein (GFP) is useful as an intracellular scaffold for the display of random peptide libraries in yeast. GFPs with a different sequence from Aequorea victoria have recently been identified from Renilla mulleri and Ptilosarcus gurn
Autor:
David C. Anderson, Ying Luo, Yngju Jang, David Padilla, Donald G. Payan, Garry P. Nolan, Betty Huang, James B. Lorens, Cindy Leo, Tarikere Gururaja, Tong Lin, Yasumichi Hitoshi, Eva Chan, Xiang Xu, Branimir I. Sikic
Publikováno v:
Nature Genetics. 27:23-29
We have expressed libraries of peptides in mammalian cells to select for trans-dominant effects on intracellular signaling systems. As an example-and to reveal pharmacologically relevant points in pathways that lead to Taxol resistance-we selected fo