Zobrazeno 1 - 10
of 10 350
pro vyhledávání: '"Targeted therapies"'
Publikováno v:
Inflammation and Regeneration, Vol 44, Iss 1, Pp 1-19 (2024)
Abstract Since chimeric antigen receptor T (CAR-T) cells were introduced three decades ago, the treatment using these cells has led to outstanding outcomes, and at the moment, CAR-T cell therapy is a well-established mainstay for treating CD19 + mali
Externí odkaz:
https://doaj.org/article/055e55e00c6444ae9384f75cf83645e1
Autor:
Jing Yan, Di Chen, Zi Ye, Xuqiang Zhu, Xueyuan Li, Henan Jiao, Mengjiao Duan, Chaoli Zhang, Jingliang Cheng, Lixia Xu, Hongjiang Li, Dongming Yan
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-32 (2024)
Abstract Tryptophan (Trp) metabolism involves three primary pathways: the kynurenine (Kyn) pathway (KP), the 5-hydroxytryptamine (serotonin, 5-HT) pathway, and the indole pathway. Under normal physiological conditions, Trp metabolism plays crucial ro
Externí odkaz:
https://doaj.org/article/8992828e1593424ea397307f1ee6b6d0
Autor:
Juliette Simon, Damien Reita, Eric Guerin, Benoit Lhermitte, Noelle Weingertner, François Lefebvre, Marie Karanian, Julien Masliah-Planchon, Veronique Lindner, Alina Onea, Sarah Jannier, Alexandra Salmon, Guillaume Bergthold, Florence Vincent, Marlène Deschuyter, Marie-Odile Barbaza, Natacha Entz-Werlé
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-18 (2024)
Abstract Introduction Faced to the growing development of collecting systematic molecular analyses in relapsed pediatric cancers to transform their targeted matched therapies, this study aimed to assess the clinical and therapeutic indications of sys
Externí odkaz:
https://doaj.org/article/fd4aae2496a942ca8d74a1c96e7ff44d
Autor:
Daniel Breadner, David M. Hwang, Don Husereau, Parneet Cheema, Sarah Doucette, Peter M. Ellis, Shaqil Kassam, Natasha Leighl, Donna E. Maziak, Shamini Selvarajah, Brandon S. Sheffield, Rosalyn A. Juergens
Publikováno v:
Current Oncology, Vol 31, Iss 10, Pp 6017-6031 (2024)
Lung cancer is the leading cause of cancer-related deaths in Canada, with non-small-cell lung cancer (NSCLC) accounting for the majority of cases. Timely access to comprehensive molecular profiling is critical for selecting biomarker-matched targeted
Externí odkaz:
https://doaj.org/article/f7cb34653c054cd781905d065bb3e78f
Publikováno v:
Case Reports in Oncology, Vol 17, Iss 1, Pp 1124-1130 (2024)
Introduction: Clear cell renal cell carcinoma (ccRCC), the most common type of kidney cancer in adults, presents significant challenges owing to its resistance to conventional therapies. Standard treatment primarily revolves around surgical methods,
Externí odkaz:
https://doaj.org/article/076105e65efc4472a9fc223c00e0aef4
Publikováno v:
Journal of Indian Academy of Oral Medicine and Radiology, Vol 36, Iss 3, Pp 254-258 (2024)
Background: Oral mucositis (OM) is an acute debilitating side effects of chemoradiotherapy (CRT) in head and neck cancer (HNC) patients. Salivary biomarkers are noninvasive and aid in early diagnosis and disease prevention. Objective: This study anal
Externí odkaz:
https://doaj.org/article/a8d59a1537ae41339e5189d7261c86df
Autor:
Lei Cao, Wencong Tian, Yongjie Zhao, Peng Song, Jia Zhao, Chuntao Wang, Yanhong Liu, Hong Fang, Xingqiang Liu
Publikováno v:
Global Medical Genetics, Vol 11, Iss 04, Pp 251-262 (2024)
Although gastrointestinal stromal tumors (GISTs) has been reported in patients of all ages, its diagnosis is more common in elders. The two most common types of mutation, receptor tyrosine kinase (KIT) and platelet-derived growth factor receptor a (P
Externí odkaz:
https://doaj.org/article/27a45c5ff0d545c584eec6ddde3be173
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-4 (2024)
Abstract Multiple classes of therapies targeting claudin-18 isoform 2 (CLDN18.2) are under development for the treatment of advanced gastroesophageal adenocarcinoma and other solid tumors. At the 2024 American Society of Clinical Oncology (ASCO) Annu
Externí odkaz:
https://doaj.org/article/7c852dae49844599adeca9f938191bc2
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Vol 7, Iss 3, Pp 159-167 (2024)
Introduction: In targeted therapies and immunotherapies, the occurrence of low-grade (e.g., grade 1–2) toxicities (LGT) is common, while dose-limiting toxicities (DLT) are relatively rare. As a result, conventional phase I trial designs, solely bas
Externí odkaz:
https://doaj.org/article/a95808ca83c7417cbe37e7c86e72bee8
Publikováno v:
Bioelectronic Medicine, Vol 10, Iss 1, Pp 1-7 (2024)
Abstract Bioelectronic Medicine (BEM), which uses implantable electronic medical devices to interface with electrically active tissues, aspires to revolutionize the way we understand and fight disease. By leveraging knowledge from microelectronics, m
Externí odkaz:
https://doaj.org/article/5cf0ed57b8a84a2fb38424fa944704b6