Zobrazeno 1 - 10
of 2 300
pro vyhledávání: '"Targeted proteomics"'
Autor:
Alexandra Rabin, Elisa Bello, Saurabh Kumar, Dalia Abou Zeki, Khashayar Afshari, Mugdha Deshpande, Nimmy Francis, Farnaz Khalighinejad, Raffaella Umeton, Irina Radu, Fatima Qutab, Danny Kwong, Mariana Kurban, Christopher Hemond, Jillian M. Richmond, Carolina Ionete
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Multiple sclerosis (MS) is an inflammatory demyelinating disease with heterogeneous clinical presentations and variable long-term disability accumulation. There are currently no standard criteria to accurately predict disease outcomes. In th
Externí odkaz:
https://doaj.org/article/41ff790284f0454e8e0950748bd5fe39
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Diabetic retinopathy (DR) is a serious complication of diabetes featuring abnormal lipid metabolism. However, the specific lipid molecules associated with onset and progression remain unclear. We used a broad-targeted lipidomics approach to
Externí odkaz:
https://doaj.org/article/ed17398087d14a919c7144ff6a5741b3
Autor:
Lauren Breithaupt, Laura M. Holsen, Chunni Ji, Jie Hu, Felicia Petterway, Megan Rosa-Caldwell, Ida A.K. Nilsson, Jennifer J. Thomas, Kyle A. Williams, Regine Boutin, Meghan Slattery, Cynthia M. Bulik, Steven E. Arnold, Elizabeth A. Lawson, Madhusmita Misra, Kamryn T. Eddy
Publikováno v:
Biological Psychiatry Global Open Science, Vol 4, Iss 5, Pp 100332- (2024)
Background: Proteomics offers potential for detecting and monitoring anorexia nervosa (AN) and its variant, atypical AN (atyp-AN). However, research has been limited by small protein panels, a focus on adult AN, and lack of replication. Methods: In t
Externí odkaz:
https://doaj.org/article/5e8ec272db2e4c6dbf96303e4cff090a
Autor:
Maitray A. Patel, Douglas D. Fraser, Mark Daley, Gediminas Cepinskas, Noemi Veraldi, Serge Grazioli
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-12 (2024)
Abstract Background The Multi-System Inflammatory Syndrome in Children (MIS-C) can develop several weeks after SARS-CoV-2 infection and requires a distinct treatment protocol. Distinguishing MIS-C from SARS-CoV-2 negative sepsis (SCNS) patients is im
Externí odkaz:
https://doaj.org/article/28ac426af3e445aba61928b19f8e4d06
Autor:
Hugo Amedei, Niels Benjamin Paul, Brian Foo, Lisa Neuenroth, Stephan E. Lehnart, Henning Urlaub, Christof Lenz
Publikováno v:
Frontiers in Analytical Science, Vol 4 (2024)
IntroductionCo-fractionation mass spectrometry couples native-like separations of protein-protein complexes with mass spectrometric proteome analysis for global characterization of protein networks. The technique allows for both de novo detection of
Externí odkaz:
https://doaj.org/article/2aede4e5fb4049c2903bdce2b375d161
Autor:
Jingjing Ma, Zhiguang Lin, Yaqi Zhang, Yun Ding, Qiming Tang, Yufeng Qian, Bo Jin, Ruben Y. Luo, Wei-Li Liao, Sheeno Thyparambil, Zhi Han, C. James Chou, James Schilling, Qing Li, Mengxue Zhang, Yunan Lin, Yan Ma, Karl G. Sylvester, Seema Nagpal, Doff B. McElhinney, Xuefeng B. Ling, Bobin Chen
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionPrimary central nervous system lymphoma (PCNSL) is a rare type of non-Hodgkin’s lymphoma that affects brain parenchyma, eyes, cerebrospinal fluid, and spinal cord. Diagnosing PCNSL can be challenging because imaging studies often show s
Externí odkaz:
https://doaj.org/article/dbd73c16b6144b0ab5b436e20370a0da
Autor:
Thais Cristina Tirado, Kelly Cavalcanti Machado, Patrícia Shigunov, Michel Batista, Fabiano Borges Figueiredo
Publikováno v:
Data in Brief, Vol 53, Iss , Pp 110217- (2024)
The targeted LC-MS/MS method has been widely applied for peptide quantification, offering sensibility, specificity, and reproducibility to the analysis. However, it requires the prior selection of targets, including the construction of a spectral lib
Externí odkaz:
https://doaj.org/article/f4f5904940d744ff93b6139aeebc2ba9
Autor:
Kodai Yajima, Takeshi Akiyoshi, Kazuho Sakamoto, Yoshiaki Suzuki, Takayuki Oka, Ayuko Imaoka, Hisao Yamamura, Junko Kurokawa, Hisakazu Ohtani
Publikováno v:
Journal of Pharmacological Sciences, Vol 153, Iss 3, Pp 153-160 (2023)
Transporter-mediated clearance is determined by two factors, its single-molecule clearance, and expression level. However, no reliable method has been developed to evaluate them separately. This study aimed to develop a reliable method for evaluating
Externí odkaz:
https://doaj.org/article/c05ac3de23b04300a276f1cd40eb7de1
Autor:
Liujia Qian, Jianqing Zhu, Zhangzhi Xue, Tingting Gong, Nan Xiang, Liang Yue, Xue Cai, Wangang Gong, Junjian Wang, Rui Sun, Wenhao Jiang, Weigang Ge, He Wang, Zhiguo Zheng, Qijun Wu, Yi Zhu, Tiannan Guo
Publikováno v:
Molecular Oncology, Vol 17, Iss 8, Pp 1567-1580 (2023)
High‐grade serous ovarian carcinoma (HGSOC) is the most common subtype of ovarian cancer with 5‐year survival rates below 40%. Neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) is recommended for patients with advanced
Externí odkaz:
https://doaj.org/article/8619fcefd55247989b5c3a84bdf9c3e1
Autor:
Keiko Kasahara, Ryohei Narumi, Satoshi Nagayama, Keiko Masuda, Tsuyoshi Esaki, Kazutaka Obama, Takeshi Tomonaga, Yoshiharu Sakai, Yoshihiro Shimizu, Jun Adachi
Publikováno v:
Cancer Medicine, Vol 12, Iss 6, Pp 7616-7626 (2023)
Abstract Purpose The pathogenesis of cancers depends on the molecular background of each individual patient. Therefore, verifying as many biomarkers as possible and clarifying their relationships with each disease status would be very valuable. We pe
Externí odkaz:
https://doaj.org/article/9dcc0f8c635348a9b9c2ce58f85e379f