Zobrazeno 1 - 10
of 1 168
pro vyhledávání: '"Targeted protein degradation"'
Autor:
Ziqi Huang, Kun Zhang, Yurui Jiang, Mengmeng Wang, Mei Li, Yuda Guo, Ruolin Gao, Ning Li, Chenyang Wang, Jia Chen, Jiefu Wang, Ning Liu, Xiang Liu, Shuangwei Liu, Mingming Wei, Cheng Yang, Guang Yang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 9, Pp 4001-4013 (2024)
Cancer stem cells (CSCs) play a pivotal role in tumor initiation, proliferation, metastasis, drug resistance, and recurrence. Consequently, targeting CSCs has emerged as a promising avenue for cancer therapy. Recently, 3-phosphoglycerate dehydrogenas
Externí odkaz:
https://doaj.org/article/f12cd5184227441eb476af3f499d3c9a
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-24 (2024)
Abstract Targeted therapies, such as small molecule kinase inhibitors, have made significant progress in the treatment of hematologic malignancies by directly modulating protein activity. However, issues such as drug toxicity, drug resistance due to
Externí odkaz:
https://doaj.org/article/44aa040c0e97457dbd58f150108b00d7
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Microtubule-associated protein tau is inextricably linked to a group of clinically diverse neurodegenerative diseases termed tauopathies. The ratio balance of the major tau splicing isoform groups (3 R- and 4 R-tau) is critical in maintaining healthy
Externí odkaz:
https://doaj.org/article/9297d8ec05824b7c802c145729c35762
Publikováno v:
eLife, Vol 13 (2024)
The development of proteolysis targeting chimeras (PROTACs), which induce the degradation of target proteins by bringing them into proximity with cellular E3 ubiquitin ligases, has revolutionized drug development. While the human genome encodes more
Externí odkaz:
https://doaj.org/article/6ebd71dcf0384a5ca00c736d20c97618
Autor:
Francis J. Prael, III, Jiayi Cox, Noé Sturm, Peter Kutchukian, William C. Forrester, Gregory Michaud, Jutta Blank, Lingling Shen, Raquel Rodríguez-Pérez
Publikováno v:
Artificial Intelligence in the Life Sciences, Vol 6, Iss , Pp 100100- (2024)
Targeted protein degradation (TPD) is a rapidly developing drug discovery technique with unique efficacy and target scope stemming from its degradation-based activity. Molecular glue degraders are a promising arm of TPD, as evidenced by the FDA-appro
Externí odkaz:
https://doaj.org/article/55a983e8b68c47b29a24a8f5a592f2c3
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The Suppressor of Cytokine Signalling (SOCS) protein family play a critical role in cytokine signalling and regulation of the JAK/STAT pathway with functional consequences to the immune response. Members of this family are implicated in multiple diff
Externí odkaz:
https://doaj.org/article/34a09c0362e74bb489f1d43a614bcd9f
Autor:
Jianghua Shi, Luo Wang, Xuanwei Zeng, Chengzhi Xie, Zhaowei Meng, Anahit Campbell, Lulu Wang, Heli Fan, Huabing Sun
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Proteolysis-targeting chimeras (PROTACs) offer a groundbreaking approach to selectively degrade disease-related proteins by utilizing the ubiquitin-proteasome system. While this strategy shows great potential in preclinical and clinical settings, off
Externí odkaz:
https://doaj.org/article/e22f7234aa9c45069bff31c5a51836d0
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 6, Pp 2402-2427 (2024)
Targeted protein degradation (TPD) represented by proteolysis targeting chimeras (PROTACs) marks a significant stride in drug discovery. A plethora of innovative technologies inspired by PROTAC have not only revolutionized the landscape of TPD but ha
Externí odkaz:
https://doaj.org/article/dadeb76a64ec4253b040e28101ee915d
Akademický článek
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Autor:
Nobendu Mukerjee
Publikováno v:
Clinical and Translational Discovery, Vol 4, Iss 4, Pp n/a-n/a (2024)
Abstract Human Immunodeficiency Virus (HIV) significantly increases the risk of various cancers due to chronic immune suppression and viral oncogenes. Traditional therapies, including antiretroviral therapy (ART), chemotherapy, and radiation, often f
Externí odkaz:
https://doaj.org/article/28c15e913b244fdea2f463cae5f9b01b