Zobrazeno 1 - 10
of 577
pro vyhledávání: '"Targeted molecular therapy"'
Autor:
Allison R. Valerius, Lauren M. Webb, Anna Thomsen, Eric J. Lehrer, William G. Breen, Jian L. Campian, Cecile Riviere-Cazaux, Terry C. Burns, Ugur Sener
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10570 (2024)
Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Despite an established standard of care including surgical resection, radiation therapy, and chemotherapy, GBM unfortunately is associated with a dismal prognosis. Therefo
Externí odkaz:
https://doaj.org/article/f800915163e4446c94f4cf39567f55a8
Autor:
Kevin P. Labadie, Adrienne L. Lehnert, Aimee L. Kenoyer, Donald K. Hamlin, Andrew D. Ludwig, Alan F. Utria, Sara K. Daniel, Tara N. Mihailovic, Alexander Prossnitz, Johnnie J. Orozco, Yawen Li, D. Scott Wilbur, Robert S. Miyaoka, James O. Park
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Background Early intrahepatic recurrence is common after surgical resection of hepatocellular carcinoma (HCC) and leads to increased morbidity and mortality. Insensitive and nonspecific diagnostic imaging contributes to EIR and results in mi
Externí odkaz:
https://doaj.org/article/de5efabc7d0b4c4991c791912e3e2374
Autor:
Ayumi Kanemaru, Satoru Shinriki, Mimi Kai, Kanae Tsurekawa, Kazuya Ozeki, Shota Uchino, Naoki Suenaga, Kou Yonemaru, Shunsuke Miyake, Takeshi Masuda, Ryusho Kariya, Seiji Okada, Hisashi Takeshita, Yuki Seki, Hiromu Yano, Yoshihiro Komohara, Ryoji Yoshida, Hideki Nakayama, Jian-Dong Li, Hideyuki Saito, Hirofumi Jono
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-17 (2022)
Abstract Background Tumor suppressor CYLD dysfunction by loss of its expression, triggers malignant transformation, especially drug resistance and tumor invasion/metastasis. Although loss of CYLD expression is significantly associated with poor progn
Externí odkaz:
https://doaj.org/article/c45d71ac42ac4c2f8a2c50b7731b06b2
Autor:
Chang Zhang, Hao Li
Publikováno v:
Pediatric Investigation, Vol 6, Iss 2, Pp 111-122 (2022)
ABSTRACT Atypical teratoid/rhabdoid tumors (AT/RTs) are lethal central nervous system tumors, which are primarily diagnosed in infants. Current treatments for AT/RTs include surgery, radiotherapy, and chemotherapy; these treatments have poor prognose
Externí odkaz:
https://doaj.org/article/deb8dc379d9b45548ac4cf373ec0c5e3
Autor:
Daniel Alexander Hescheler, Milan Janis Michael Hartmann, Burkhard Riemann, Maximilian Michel, Christiane Josephine Bruns, Hakan Alakus, Costanza Chiapponi
Publikováno v:
Endocrine Connections, Vol 11, Iss 4, Pp 1-13 (2022)
Objective: Anaplastic thyroid cancer (ATC) is one of the most lethal human cancers with meager treatment options. We aimed to identify the targeted drugs already approved by the Food and Drug Administration (FDA) for solid cancer in general, which co
Externí odkaz:
https://doaj.org/article/cbb104cb020247e2b52d12a4064a821a
Publikováno v:
Frontiers in Surgery, Vol 9 (2023)
Diffuse malignant peritoneal mesothelioma (DMPM) is an unusual and life-threatening locally invasive tumor. The morbidity and mortality of the disease are associated with progressive local effects in the abdominal cavity, such as abdominal distention
Externí odkaz:
https://doaj.org/article/496adaae50114a18a79d7074202219d0
Autor:
Faustyna Piędel, Agata Agnieszka Rocka, Klaudia Daria Szumna, Dominika Katarzyna Madras, Patryk Piotr Jasielski
Publikováno v:
Journal of Education, Health and Sport, Vol 10, Iss 3, Pp 133-139 (2020)
Introduction: According to the National Cancer Register in Poland, the number of cancers including breast cancers has more than doubled in the past three decades. Poly(ADP-ribose) polymerase (PARP) inhibitors lead to the death of cells with a BRCA1/2
Externí odkaz:
https://doaj.org/article/aa469454b0604acbb55b48b8a6a53ec4
Autor:
Daniel A. Hescheler, Burkhard Riemann, Milan J. M. Hartmann, Maximilian Michel, Michael Faust, Christiane J. Bruns, Hakan Alakus, Costanza Chiapponi
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
BackgroundA limited number of targeted therapy options exist for papillary thyroid cancer (PTC) to date. Based on genetic alterations reported by the “The Cancer Genome Atlas (TCGA)”, we explored whether PTC shows alterations that may be targetab
Externí odkaz:
https://doaj.org/article/d07d402afccd4e9794144d52258d53df
Autor:
Alec Kacew, Randy F. Sweis
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
FGFR3 is a prognostic and predictive marker and is a validated therapeutic target in urothelial bladder cancer. Its utility as a marker and target in the context of immunotherapy is incompletely understood. We review the role of FGFR3 in bladder canc
Externí odkaz:
https://doaj.org/article/adddc4ad2aea42a79a9dd433f47468fe
