Zobrazeno 1 - 10
of 241
pro vyhledávání: '"Targeted enrichment"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101352- (2024)
Evaluation of host integration profiles by adeno-associated virus (AAV) is an important component of de-risking novel AAV gene therapies. Targeted enrichment sequencing (TES) is a cost-effective and comprehensive method for assessing integration. Mos
Externí odkaz:
https://doaj.org/article/654cd3cfc1ad47d7988230718f57b959
Autor:
Jake D'Addiego, Sonal Shah, Ayşe Nur Pektaş, Bi̇nnur Köksal Bağci, Murtaza Öz, Sasha Sebastianelli, Nazif Elaldı, David J Allen, Roger Hewson
Publikováno v:
Virus Research, Vol 350, Iss , Pp 199464- (2024)
Crimean-Congo haemorrhagic fever (CCHF) is the most prevalent human tick-borne viral disease, with a reported case fatality rate of 30 % or higher. The virus contains a tri-segmented, negative-sense RNA genome consisting of the small (S), medium (M)
Externí odkaz:
https://doaj.org/article/a55ee49ef89645f682a39966e56229d1
Autor:
Cristina Mejías-Molina, Anna Pico-Tomàs, Sandra Martínez-Puchol, Marta Itarte, Helena Torrell, Núria Canela, Carles M. Borrego, Lluís Corominas, Marta Rusiñol, Sílvia Bofill-Mas
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-14 (2024)
Abstract Background Human viruses released into the environment can be detected and characterized in wastewater. The study of wastewater virome offers a consolidated perspective on the circulation of viruses within a population. Because the occurrenc
Externí odkaz:
https://doaj.org/article/e44ee5caddbf4c8db1c4a52689faaf60
Autor:
Adrian C. Paskey, Kevin L. Schully, Logan J. Voegtly, Catherine E. Arnold, Regina Z. Cer, Kenneth G. Frey, Paul W. Blair, Danielle V. Clark, Hong Ge, Allen L. Richards, Christina M. Farris, Kimberly A. Bishop-Lilly
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Infection with either Rickettsia prowazekii or Orientia tsutsugamushi is common, yet diagnostic capabilities are limited due to the short window for positive identification. Until now, although targeted enrichment had been applied to increase sensiti
Externí odkaz:
https://doaj.org/article/3d595ae3e3004b54a1737aa718e68971
Autor:
Elias M. Oziolor, Steven W. Kumpf, Jessie Qian, Mark Gosink, Mark Sheehan, David M. Rubitski, Leah Newman, Laurence O. Whiteley, Thomas A. Lanz
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 395-405 (2023)
Many current gene therapy targets use recombinant adeno-associated virus (AAV). The majority of delivered AAV therapeutics persist as episomes, separate from host DNA, yet some viral DNA can integrate into host DNA in different proportions and at gen
Externí odkaz:
https://doaj.org/article/408d92ef4a474a9ab96737ca95b99093
Autor:
Christina Wurst, Frank Maixner, Alice Paladin, Alexandra Mussauer, Guido Valverde, Jagat Narula, Randall Thompson, Albert Zink
Publikováno v:
Annals of Global Health, Vol 90, Iss 1, Pp 6-6 (2024)
Background: Several computed tomographic studies have shown the presence of atherosclerosis in ancient human remains. However, while it is important to understand the development of atherosclerotic cardiovascular disease (ASCVD), genetic data concern
Externí odkaz:
https://doaj.org/article/3f3e3bd292204ad4911fd7469cb57c37
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Akademický článek
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Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-15 (2021)
Abstract Photothermal therapy (PTT), which converts light energy to heat energy, has become a new research hotspot in cancer treatment. Although researchers have investigated various ways to improve the efficiency of tumor heat ablation to treat canc
Externí odkaz:
https://doaj.org/article/a541424e0a654670a983b3516bc987c0