Zobrazeno 1 - 10
of 7 352
pro vyhledávání: '"Target protein"'
Publikováno v:
Guangdong nongye kexue, Vol 51, Iss 8, Pp 138-150 (2024)
Ralstonia solanacearum usually infects the vascular bundle system through the roots of host plants, causing bacterial wilt and leading to irreversible wilting and death of plants. Bacterial wilt is a devastating soil-borne bacterial disease. At prese
Externí odkaz:
https://doaj.org/article/03c5f94a358d4b818228ac44c48c3214
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Recent studies have shifted the spotlight from adult disease to gametogenesis and embryo developmental events, and these are greatly affected by various environmental chemicals, such as drugs, metabolites, pollutants, and others. Growing res
Externí odkaz:
https://doaj.org/article/6fe029b931814ba4acb13ffd70a9b110
Autor:
Lan Huang, Buqing Ma, Chong Zhang, Jiaqi Shi, Rui Shen, Erci Zhang, Chenlei Lian, Cuifang Wang, Jieqing Liu
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-14 (2023)
Abstract Background Prostate cancer is a disease that seriously troubles men. However, there are some inevitable limitations in interventional therapy for prostate cancer patients at present, most of which are caused by low selectivity and high toxic
Externí odkaz:
https://doaj.org/article/a1a5a2510b1b45a292622d10218bcecc
Autor:
Qiao-Yu Fang, Yue-Ping Wang, Rui-Qin Zhang, Meng Fan, Li-Xing Feng, Xiao-Dong Guo, Chun-Ru Cheng, Xiong-Wen Zhang, Xuan Liu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Introduction: Carnosol exhibited ameliorating effects on muscle atrophy of mice developed cancer cachexia in our previous research.Method: Here, the ameliorating effects of carnosol on the C2C12 myotube atrophy result from simulated cancer cachexia i
Externí odkaz:
https://doaj.org/article/9a36eac94e424db5a4b09e00b3937853
Publikováno v:
Mathematical Biosciences and Engineering, Vol 20, Iss 6, Pp 10610-10625 (2023)
The prediction of drug-target protein interaction (DTI) is a crucial task in the development of new drugs in modern medicine. Accurately identifying DTI through computer simulations can significantly reduce development time and costs. In recent years
Externí odkaz:
https://doaj.org/article/8b57e8f1009040fcb9ceb116c22cae9b
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 662 (2024)
Keloid is characterized as the fibrotic tissue resulting from the increase of fibroblast activity. Uncaria gambir (Hunter) Roxb. possesses bioactive compounds that have potential as antifibrotic agents, while the mechanism of action in keloid has not
Externí odkaz:
https://doaj.org/article/6758287e65a04f3e96ccee5b0eb8fd36
Autor:
Xiao Jie, Zhang Ben, Yin Songmei, Xie Shuangfeng, Huang Kezhi, Wang Jieyu, Yang Wenjuan, Liu Hongyun, Zhang Guoyang, Liu Xiaoyan, Li Yiqing, Nie Danian
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 54, Pp 1244-1256 (2022)
Acute myeloid leukemia (AML) is one of the most common malignancies of the hematopoietic progenitor cell in adults. Quercetin has gained recognition over the years because of its anti-cancer effect with minimal toxicity. Herein, we aim to investigate
Externí odkaz:
https://doaj.org/article/c7c11c894f1e49118174cc222314c94a
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Methods for efficient insoluble protein production require further exploration. PagP, an Escherichia coli outer membrane protein with high β-sheet content, could function as an efficient fusion partner for inclusion body-targeted expression
Externí odkaz:
https://doaj.org/article/04be702e81ce4bbb9cb60852396056bb
Autor:
Hui Zhong, Qi Jiang, Cong Wu, Huanghe Yu, Bin Li, Xudong Zhou, Ronggeng Fu, Wei Wang, Wenbing Sheng
Publikováno v:
Molecules, Vol 29, Iss 2, p 409 (2024)
Five artemisinin bivalent ligands molecules 4a–4e were designed, synthesized, and confirmed by 1H NMR, 13C NMR, and low-resolution mass spectrometry, and the bioactivities of the target compounds were investigated against four human tumor cell line
Externí odkaz:
https://doaj.org/article/3a1e45c880bc43fb8b681ba84029c18d
Publikováno v:
Cells, Vol 13, Iss 2, p 175 (2024)
This review explores various methods for modulating protein stability to achieve target protein degradation, which is a crucial aspect in the study of biological processes and drug design. Thirty years have passed since the introduction of heat-induc
Externí odkaz:
https://doaj.org/article/52fcbb25205842af8767eee6fd25bd2e