Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Target identification and validation"'
Autor:
Matthew J. Winter, Yosuke Ono, Jonathan S. Ball, Anna Walentinsson, Erik Michaelsson, Anna Tochwin, Steffen Scholpp, Charles R. Tyler, Steve Rees, Malcolm J Hetheridge, Mohammad Bohlooly-Y
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The clinical heterogeneity of heart failure has challenged our understanding of the underlying genetic mechanisms of this disease. In this respect, large-scale patient DNA sequencing studies have become an invaluable strategy for identifying potentia
Externí odkaz:
https://doaj.org/article/c5241e27f188422cbb46be887827542a
Autor:
Benjamin S. Glicksberg, Letizia Amadori, Nicholas K. Akers, Katyayani Sukhavasi, Oscar Franzén, Li Li, Gillian M. Belbin, Kristin L. Akers, Khader Shameer, Marcus A. Badgeley, Kipp W. Johnson, Ben Readhead, Bruce J. Darrow, Eimear E. Kenny, Christer Betsholtz, Raili Ermel, Josefin Skogsberg, Arno Ruusalepp, Eric E. Schadt, Joel T. Dudley, Hongxia Ren, Jason C. Kovacic, Chiara Giannarelli, Shuyu D. Li, Johan L. M. Björkegren, Rong Chen
Publikováno v:
BMC Medical Genomics, Vol 12, Iss S6, Pp 1-16 (2019)
Abstract Background Genetic loss-of-function variants (LoFs) associated with disease traits are increasingly recognized as critical evidence for the selection of therapeutic targets. We integrated the analysis of genetic and clinical data from 10,511
Externí odkaz:
https://doaj.org/article/a76b99477ddb49caaac1147906552dfc
Publikováno v:
Brazilian Archives of Biology and Technology, Vol 62 (2019)
Abstract Phytochemicals present in plant extract include a number of biological active compounds which have shown promising antioxidant and anti-inflammatory activities in many animal studies. Present knowledge about the biochemical interactions of t
Externí odkaz:
https://doaj.org/article/5fea7d85c8654b4cb534321528558c50
Autor:
Bo Liu, Omar Abdel-Wahab
Publikováno v:
eLife, Vol 6 (2017)
The loss of genes that encode RNA splicing factors weakens cancer cells in a way that could be exploited by new approaches to treatment.
Externí odkaz:
https://doaj.org/article/f07a5304ec44458a945b141fe8f154a5
Autor:
Brenton R Paolella, William J Gibson, Laura M Urbanski, John A Alberta, Travis I Zack, Pratiti Bandopadhayay, Caitlin A Nichols, Pankaj K Agarwalla, Meredith S Brown, Rebecca Lamothe, Yong Yu, Peter S Choi, Esther A Obeng, Dirk Heckl, Guo Wei, Belinda Wang, Aviad Tsherniak, Francisca Vazquez, Barbara A Weir, David E Root, Glenn S Cowley, Sara J Buhrlage, Charles D Stiles, Benjamin L Ebert, William C Hahn, Robin Reed, Rameen Beroukhim
Publikováno v:
eLife, Vol 6 (2017)
Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes that are essential in the context
Externí odkaz:
https://doaj.org/article/8eec2bdf4b584beabb46e378e18f1d59
Publikováno v:
Current Opinion in Chemical Biology. 60:20-29
Activity-based protein profiling (ABPP) is recognized as a powerful and versatile chemoproteomic technology in drug discovery. Central to ABPP is the use of activity-based probes to report the activity of specific enzymes or reactivity of amino acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec62b9087b27c16b9beea787ad7ef08
https://doi.org/10.1016/j.cbpa.2020.06.011
https://doi.org/10.1016/j.cbpa.2020.06.011
Akademický článek
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Akademický článek
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Autor:
Johan Björkegren, Rong Chen, Arno Ruusalepp, Letizia Amadori, Kipp W. Johnson, Benjamin S. Glicksberg, Nicholas K. Akers, Li Li, Christer Betsholtz, Chiara Giannarelli, Khader Shameer, Gillian M. Belbin, Marcus A. Badgeley, Ben Readhead, Hongxia Ren, Kristin L. Ayers, Oscar Franzén, Katyayani Sukhavasi, Bruce J. Darrow, Jason C. Kovacic, Josefin Skogsberg, Eimear E. Kenny, Joel T. Dudley, Eric E. Schadt, Shuyu D. Li, Raili Ermel
Publikováno v:
BMC Medical Genomics
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-1 (2019)
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-1 (2019)
Background Genetic loss-of-function variants (LoFs) associated with disease traits are increasingly recognized as critical evidence for the selection of therapeutic targets. We integrated the analysis of genetic and clinical data from 10,511 individu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff92adecb637039a739a9b8cb0711b6
https://doi.org/10.1186/s12920-019-0573-9
https://doi.org/10.1186/s12920-019-0573-9
Kniha
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