Zobrazeno 1 - 10
of 1 294
pro vyhledávání: '"Target engagement"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
T-cell engagers (TCEs) represent a promising therapeutic strategy for various cancers and autoimmune disorders. These bispecific antibodies act as bridges, connecting T-cell receptors (TCRs) to target cells (either malignant or autoreactive) via inte
Externí odkaz:
https://doaj.org/article/f29c23aa266f4820aa6aa24bd23b7e43
Autor:
Joseph A. Bell, Elizabeth R. Davies, Christopher J. Brereton, Milica Vukmirovic, James J.W. Roberts, Kerry Lunn, Leanne Wickens, Franco Conforti, Robert A. Ridley, Jessica Ceccato, Lucy N. Sayer, David A. Johnston, Andres F. Vallejo, Aiman Alzetani, Sanjay Jogai, Ben G. Marshall, Aurelie Fabre, Luca Richeldi, Phillip D. Monk, Paul Skipp, Naftali Kaminski, Emily Offer, Yihua Wang, Donna E. Davies, Mark G. Jones
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101695- (2024)
Summary: Matrix stiffening by lysyl oxidase-like 2 (LOXL2)-mediated collagen cross-linking is proposed as a core feedforward mechanism that promotes fibrogenesis. Failure in clinical trials of simtuzumab (the humanized version of AB0023, a monoclonal
Externí odkaz:
https://doaj.org/article/28bf070de21f4af1b6319da757012509
Autor:
Seiji Watanabe, Kangsa Amporndanai, Raheela Awais, Caroline Latham, Muhammad Awais, Paul M. O’Neill, Koji Yamanaka, S. Samar Hasnain
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Amyotrophic lateral sclerosis (ALS) selectively affects motor neurons. SOD1 is the first causative gene to be identified for ALS and accounts for at least 20% of the familial (fALS) and up to 4% of sporadic (sALS) cases globally with some ge
Externí odkaz:
https://doaj.org/article/5cce70c881dc4718bdc19c5c4fdd5fa7
Autor:
Valentina Kugler, Selina Schwaighofer, Andreas Feichtner, Florian Enzler, Jakob Fleischmann, Sophie Strich, Sarah Schwarz, Rebecca Wilson, Philipp Tschaikner, Jakob Troppmair, Veronika Sexl, Pascal Meier, Teresa Kaserer, Eduard Stefan
Publikováno v:
eLife, Vol 13 (2024)
Protein kinases act as central molecular switches in the control of cellular functions. Alterations in the regulation and function of protein kinases may provoke diseases including cancer. In this study we investigate the conformational states of suc
Externí odkaz:
https://doaj.org/article/71c92e4b1a0b490fa5cb3387e2ae8a9c
Autor:
Jacob L. Capener, James D. Vasta, Vittorio L. Katis, Ani Michaud, Michael T. Beck, Sabrina C. D. Daglish, Sarit Cohen-Kedar, Efrat Shaham Barda, Stefanie Howell, Iris Dotan, Matthew B. Robers, Alison D. Axtman, Frances M. Bashore
Publikováno v:
Frontiers in Chemical Biology, Vol 3 (2024)
Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase that is activated by phosphorylation events downstream of FcR, B-cell and T-cell receptors, integrins, and C-type lectin receptors. When the tandem Src homology 2 (SH2) domains of SYK bin
Externí odkaz:
https://doaj.org/article/5b14e25fb79449cd9a67529c673d86a8
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Intra-Target Microdosing (ITM), integral to Phase 0 clinical studies, offers a novel approach in drug development, effectively bridging the gap between preclinical and clinical phases. This methodology is especially relevant in streamlining early dru
Externí odkaz:
https://doaj.org/article/964904260afd4e1d9f72395df60255d0
Autor:
Christopher Fotsch, Debaleena Basu, Ryan Case, Qing Chen, Pratibha C. Koneru, Mei-Chu Lo, Rachel Ngo, Pooja Sharma, Amit Vaish, Xiang Yi, Stephan G. Zech, Peter Hodder
Publikováno v:
SLAS Discovery, Vol 29, Iss 4, Pp 100159- (2024)
To confirm target engagement of hits from our high-throughput screening efforts, we ran biophysical assays on several hundreds of hits from 15 different high-throughput screening campaigns. Analyzing the biophysical assay results from these screening
Externí odkaz:
https://doaj.org/article/2deb87592cfb4d24ab3ef0bdbdb9d00b
Autor:
Jimin Ren, Richard B. Dewey, Austin Rynders, Jacob Evan, Jeremy Evan, Shelia Ligozio, Karen S. Ho, Peter V. Sguigna, Robert Glanzman, Michael T. Hotchkin, Benjamin M. Greenberg
Publikováno v:
Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-11 (2023)
Abstract Background Impaired brain energy metabolism has been observed in many neurodegenerative diseases, including Parkinson’s disease (PD) and multiple sclerosis (MS). In both diseases, mitochondrial dysfunction and energetic impairment can lead
Externí odkaz:
https://doaj.org/article/26003f0f906d41cca6145faaa4fda104
Autor:
Shitalben Patel, Marie Karlsson, Joseph T. Klahn, Frank Gambino, Jr., Helena Costa, Kathleen A. McGuire, Christina K. Baumgartner, Jon Williams, Sarah Sandoz, James E. Kath
Publikováno v:
SLAS Discovery, Vol 29, Iss 2, Pp 100135- (2024)
The cellular thermal shift assay (CETSA®) is a target engagement method widely used for preclinical characterization of small molecule compounds. CETSA® has been used for semi-quantitative readouts in whole blood with PBMC isolation, and quantitati
Externí odkaz:
https://doaj.org/article/80857a2b20534901930e128e510dcb8b
Autor:
Spiro P. Pantazatos, James R. Mclntosh, Golbarg T. Saber, Xiaoxiao Sun, Jayce Doose, Josef Faller, Yida Lin, Joshua B. Teves, Aidan Blankenship, Sarah Huffman, Robin I. Goldman, Mark S. George, Paul Sajda, Truman R. Brown
Publikováno v:
Brain Stimulation, Vol 16, Iss 3, Pp 830-839 (2023)
Background: The communication through coherence model posits that brain rhythms are synchronized across different frequency bands and that effective connectivity strength between interacting regions depends on their phase relation. Evidence to suppor
Externí odkaz:
https://doaj.org/article/125bc3fa5fc941f58b425462b8d74fba