Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Tarextumab"'
Autor:
Zishuo Ian Hu, Johanna C. Bendell, Andrea Bullock, Noelle K. LoConte, Hassan Hatoum, Paul Ritch, Hugo Hool, Joseph W. Leach, James Sanchez, Davendra P. S. Sohal, John Strickler, Ravindranath Patel, Andrea Wang‐Gillam, Irfan Firdaus, Kenneth H. Yu, Ann M. Kapoun, Eric Holmgren, Lei Zhou, Jakob Dupont, Vincent Picozzi, Vaibhav Sahai, Eileen M. O'Reilly
Publikováno v:
Cancer Medicine, Vol 8, Iss 11, Pp 5148-5157 (2019)
Abstract Purpose Notch signaling dysregulation is implicated in the development of pancreatic adenocarcinoma (PDAC). Tarextumab is a fully human IgG2 antibody that inhibits Notch2/3 receptors. Patients and Methods Aphase 2, randomized, placebo‐cont
Externí odkaz:
https://doaj.org/article/65d331d0de7c4b2799fe21f23c85e265
Autor:
Kenneth H. Yu, James Sanchez, Jakob Dupont, Hassan Hatoum, Noelle K. LoConte, Eric Holmgren, Zishuo Ian Hu, Davendra Sohal, Paul S. Ritch, Andrea Wang-Gillam, John H. Strickler, Ravindranath Patel, Irfan Firdaus, Hugo Hool, Lei Zhou, Ann M. Kapoun, Andrea J. Bullock, Johanna C. Bendell, Eileen M. O'Reilly, Vaibhav Sahai, Joseph W. Leach, Vincent J. Picozzi
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 8, Iss 11, Pp 5148-5157 (2019)
Cancer Medicine, Vol 8, Iss 11, Pp 5148-5157 (2019)
Purpose Notch signaling dysregulation is implicated in the development of pancreatic adenocarcinoma (PDAC). Tarextumab is a fully human IgG2 antibody that inhibits Notch2/3 receptors. Patients and methods Aphase 2, randomized, placebo-controlled, mul
Autor:
Shi Hu, Ying Tang, Yue Yu, Wenyan Fu, Xuting Ye, Min Ding, Shuowu Liu, Yongji Yang, Fangxing Lin, Xiaoyan Fan, Changhai Lei, Tian Li, Yafeng Shen
Publikováno v:
Clinical Cancer Research. 25:2835-2847
Purpose: Both EGFR and PI3K-Akt signaling pathways have been used as therapeutically actionable targets, but resistance is frequently reported. In this report, we show that enrichment of the cancer stem cell (CSC) subsets and dysregulation of Notch s
A phase 1 dose escalation and expansion study of Tarextumab (OMP-59R5) in patients with solid tumors
Autor:
Anthony W. Tolcher, Kyriakos P. Papadopoulos, Rashmi Chugh, David Smith, Robert Joseph Stagg, Ann M. Kapoun, Amita Patnaik, Min Wang, Lu Xu, Jakob Dupont
Publikováno v:
Investigational New Drugs
Summary Purpose This Phase I trial evaluated the maximum tolerated dose, safety, pharmacokinetics, pharmacodynamics and preliminary efficacy of tarextumab (OMP-5948), a novel cross-reactive antibody which binds and selectively inhibits signaling via
Publikováno v:
Clinical Cancer Research. 21:955-961
Over 100 years have passed since the first observation of the notched wing phenotype in Drosophila melanogaster, and significant progress has been made to characterize the role of the Notch receptor, its ligands, downstream targets, and cross-talk wi
Autor:
Gaojian Lv, Ying Tang, Changhai Lei, Feifei Wang, Shi Hu, Yongji Yang, Wenyan Fu, Xuting Ye, Tian Li, Xiaoyan Fan, Yafeng Shen, Fangxing Lin, Yuanyuan Lv, Qingning Yuan
Publikováno v:
Science translational medicine. 9(380)
Epidermal growth factor receptor (EGFR) blockade and radiation are efficacious in the treatment of cancer, but resistance is commonly reported. Studies have suggested that dysregulation of Notch signaling and enrichment of the cancer stem cell popula
The Notch pathway and the Wnt pathway are fundamental stem cell pathways that are frequently deregulated in cancer, and components of these pathways have long been recognized to possess oncogenic potential. However, efforts to generate therapeutics h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c1d3e6780bcc439227d1adf6cedc066
https://doi.org/10.1016/b978-0-12-803892-5.00017-6
https://doi.org/10.1016/b978-0-12-803892-5.00017-6
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Akademický článek
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Autor:
Anne C. Chiang, Afshin Dowlati, Jerome H. Goldschmidt, Ann M. Kapoun, T.J. Beck, Davey B. Daniel, Grace K. Dy, Lowell L. Hart, David R. Spigel, Bonnie S. Glisson, Stephen V. Liu, Leonardo Faoro, Robert M. Jotte, Charles M. Rudin, Martin J. Edelman, Rodolfo Bordoni, Timothy F. Burns
Publikováno v:
Annals of Oncology. 28:v540