Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Tarek Z, Deeb"'
Autor:
Noell Cho, Georgina Kontou, Joshua L. Smalley, Christopher Bope, Jacob Dengler, Kristopher Montrose, Tarek Z. Deeb, Nicholas J. Brandon, Tadashi Yamamoto, Paul A. Davies, Georgios Giamas, Stephen J. Moss
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109512- (2024)
Summary: LMTK3 is a brain-specific transmembrane serine/threonine protein kinase that acts as a scaffold for protein phosphatase-1 (PP1). Although LMKT3 has been identified as a risk factor for autism and epilepsy, its physiological significance is u
Externí odkaz:
https://doaj.org/article/fe648812ed2245d28cd51d531ae0f3c3
Autor:
Joshua L. Smalley, Georgina Kontou, Catherine Choi, Qiu Ren, David Albrecht, Krithika Abiraman, Miguel A. Rodriguez Santos, Christopher E. Bope, Tarek Z. Deeb, Paul A. Davies, Nicholas J. Brandon, Stephen J. Moss
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanisms neurons use to regulate its membrane trafficking, stability and activity are ill-defined. To address these issues, we used affinity purifi
Externí odkaz:
https://doaj.org/article/baaab0297501451c838881430fb7712c
Autor:
Matt R. Kelley, Ross A. Cardarelli, Joshua L. Smalley, Thomas A. Ollerhead, Peter M. Andrew, Nicholas J. Brandon, Tarek Z. Deeb, Stephen J. Moss
Publikováno v:
EBioMedicine, Vol 32, Iss , Pp 62-71 (2018)
Mesial temporal lobe epilepsy (mTLE) is the most common form of epilepsy, believed to arise in part from compromised GABAergic inhibition. The neuronal specific K+/Cl− co-transporter 2 (KCC2) is a critical determinant of the efficacy of GABAergic i
Externí odkaz:
https://doaj.org/article/48778aaa8f3145169b545ba38e5c06bc
Autor:
Jianjia Fan, Rui Qi Zhao, Cameron Parro, Wenchen Zhao, Hsien-Ya Chou, Jerome Robert, Tarek Z. Deeb, Carina Raynoschek, Samantha Barichievy, Ola Engkvist, Marcello Maresca, Ryan Hicks, Johan Meuller, Stephen J. Moss, Nicholas J. Brandon, Michael W. Wood, Iva Kulic, Cheryl L. Wellington
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 5, Pp 830-842 (2018)
apoE is the primary lipid carrier within the CNS and the strongest genetic risk factor for late onset Alzheimer's disease (AD). apoE is primarily lipidated via ABCA1, and both are under transcriptional regulation by the nuclear liver X receptor (LXR)
Externí odkaz:
https://doaj.org/article/07292a8383824ead85d89855673a9620
Autor:
Yvonne E. Moore, Leslie C. Conway, Heike J. Wobst, Nicholas J. Brandon, Tarek Z. Deeb, Stephen J. Moss
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
GABAA receptor-mediated currents shift from excitatory to inhibitory during postnatal brain development in rodents. A postnatal increase in KCC2 protein expression is considered to be the sole mechanism controlling the developmental onset of hyperpol
Externí odkaz:
https://doaj.org/article/2d919810634e497cb6cdda67faa87e98
Autor:
Christopher Lucaj, Jamie Maguire, Nicholas J. Brandon, Stephen J. Moss, Tarek Z. Deeb, Krithika Abiraman, Thomas A. Ollerhead, Kathryn L Lee
Publikováno v:
Brain
First-in-line benzodiazepine treatment fails to terminate seizures in about 30% of epilepsy patients, highlighting a need for novel antiseizure strategies. Impaired GABAergic inhibition is key to the development of such benzodiazepine-resistant seizu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018a4df44f63b60805563c8f4bd561c8
https://europepmc.org/articles/PMC9050525/
https://europepmc.org/articles/PMC9050525/
Autor:
Eamonn Sheridan, Ellanor L. Whiteley, Tarek Z. Deeb, Roland Bürli, Nicholas J. Brandon, Gonzalo S. Tejeda, George S. Baillie, Stephen J. Moss
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Phosphodiesterase 10A (PDE10A) is as a target of interest in Huntington’s disease (HD) as levels of the enzyme have been shown to decrease prior to the development of the hallmark motor symptoms. Clearly, a better understanding of how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e5e26a2f4c7b5ae300e2ca14df891e
http://europepmc.org/articles/PMC6955301
http://europepmc.org/articles/PMC6955301
Autor:
Nicholas J. Brandon, Georgina Kontou, Paul Davies, Joshua L. Smalley, David Albrecht, Miguel A. Rodriguez Santos, Tarek Z. Deeb, Stephen J. Moss, Krithika Abiraman, Catherine Choi, Qiu Ren, Christopher E. Bope
KCC2 plays a critical role in determining the efficacy of synaptic inhibition and deficits in its activity lead to epilepsy and neurodevelopmental delay. Here we use unbiased proteomic analyses to demonstrate that KCC2 forms stable protein complexes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45867b0170f1a2dfd9ed2aca472d6d00
Autor:
Joshua L. Smalley, Peter M. Andrew, Stephen J. Moss, Matt R. Kelley, Tarek Z. Deeb, Thomas A. Ollerhead, Ross A. Cardarelli, Nicholas J. Brandon
Publikováno v:
EBioMedicine, Vol 32, Iss, Pp 62-71 (2018)
EBioMedicine
EBioMedicine
Mesial temporal lobe epilepsy (mTLE) is the most common form of epilepsy, believed to arise in part from compromised GABAergic inhibition. The neuronal specific K+/Cl− co-transporter 2 (KCC2) is a critical determinant of the efficacy of GABAergic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7b82eca4c78d2007ade07cec0d8503
https://doi.org/10.1016/j.ebiom.2018.05.029
https://doi.org/10.1016/j.ebiom.2018.05.029
Autor:
Wenchen Zhao, Johan Meuller, Jianjia Fan, Carina Raynoschek, Jerome Robert, Cheryl L. Wellington, Iva Kulic, Tarek Z. Deeb, Samantha Barichievy, Rui Qi Zhao, Cameron Parro, Hsien-Ya Chou, Ryan Hicks, Ola Engkvist, Nicholas J. Brandon, Marcello Maresca, Stephen J. Moss, Michael W. Wood
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 5, Pp 830-842 (2018)
J Lipid Res
J Lipid Res
apoE is the primary lipid carrier within the CNS and the strongest genetic risk factor for late onset Alzheimer's disease (AD). apoE is primarily lipidated via ABCA1, and both are under transcriptional regulation by the nuclear liver X receptor (LXR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9cf9291f69614030989bdc48aae7ff
https://doi.org/10.1194/jlr.m081851
https://doi.org/10.1194/jlr.m081851