Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Tarek M. A. Abdel-Fatah"'
Autor:
Gemma A. Foulds, Jayakumar Vadakekolathu, Tarek M. A. Abdel-Fatah, Divya Nagarajan, Stephen Reeder, Catherine Johnson, Simon Hood, Paul M. Moseley, Stephen Y. T. Chan, A. Graham Pockley, Sergio Rutella, Stephanie E. B. McArdle
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Background: Interactions between the immune system and tumors are highly reciprocal in nature, leading to speculation that tumor recurrence or therapeutic resistance could be influenced or predicted by immune events that manifest locally, but can be
Externí odkaz:
https://doaj.org/article/ff8ec7bc8e834c0b9816a47eb4669bf7
Autor:
Emad A. Rakha, Tarek M. A. Abdel-Fatah, Muslim L. Alabdullah, Nigel P. Mongan, Adel Alblihy, Islam M. Miligy, Paul M. Moseley, Mashael Algethami, Michael S. Toss, Satya Narayan, Mansour Alsaleem, Stephen Chan, Reem Ali, Srinivasan Madhusudan
Publikováno v:
Oncogene
Targeting PARP1 [Poly(ADP-Ribose) Polymerase 1] for synthetic lethality is a new strategy for BRCA germ-line mutated or platinum sensitive ovarian cancers. However, not all patients respond due to intrinsic or acquired resistance to PARP1 inhibitor.
Autor:
Geraldine Laven-Law, Wilbert Zwart, Tarek M. A. Abdel-Fatah, Theresa E. Hickey, Mun N. Hui, Sarah Alexandrou, Luke A. Selth, Kee Ming Chia, Ian O. Ellis, C. Elizabeth Caldon, Daniel L. Roden, Jessica Finlay-Schultz, Suzan Stelloo, Shalini Jindal, Alexander Swarbrick, Wayne D. Tilley, Stephen N. Birrell, Carol A. Sartorius, Heloisa Helena Milioli, Richard Iggo, Carlo Palmieri, Esmaeil Ebrahimie, Jason S. Carroll, Elgene Lim
Publikováno v:
Nature Medicine, 27, pp. 310-320
Nature Medicine, 27, 310-320
NATURE MEDICINE
Nature Medicine, 27, 310-320
NATURE MEDICINE
The role of the androgen receptor (AR) in estrogen receptor (ER)-α-positive breast cancer is controversial, constraining implementation of AR-directed therapies. Using a diverse, clinically relevant panel of cell-line and patient-derived models, we
Autor:
Tarek M. A. Abdel-Fatah, Reem Ali, Pei Wen Chiang, Muslim L. Alabdullah, Ahmed Shoqafi, Nigel P. Mongan, Emad A. Rakha, Adel Alblihy, Islam M. Miligy, Katia A. Mesquita, Alan E. Tomkinson, Srinivasan Madhusudan, Mashael Algethami, Stephen Chan
Publikováno v:
Theranostics
Rationale: The human ligases (LIG1, LIG3 and LIG4) are essential for the maintenance of genomic integrity by catalysing the formation of phosphodiester bonds between adjacent 5′-phosphoryl and 3′-hydroxyl termini at single and double strand break
Autor:
Jennifer Walker, Elisabetta Giannotti, Stephen Chan, Graham Ball, Arlene Chan, Xin Chen, Emad Rakhah, Tarek M. A. Abdel-Fatah, Ian O. Ellis, Dorothee P. Auer, Ruizhe Li, A. Graham Pockley, Jun Lim
Publikováno v:
Cancer Research. 80:P3-07
Background: Recently neoadjuvant chemotherapy (NACT) is regarded as a potential standard approach whenever chemotherapy is indicated in principle and is considered as the preferred treatment approach for stage II/III triple-negative and HER2-positive
Autor:
Jennie N. Jeyapalan, Tarek M. A. Abdel-Fatah, Emad A. Rakha, Ahmed Shoqafi, Juliette Servante, Adel Alblihy, Stephen Chan, Mashael Algethami, Anna E. Harris, Michael S. Toss, Srinivasan Madhusudan, Andrew R. Green, Nigel P. Mongan
Publikováno v:
NPJ Breast Cancer
npj Breast Cancer, Vol 7, Iss 1, Pp 1-10 (2021)
npj Breast Cancer, Vol 7, Iss 1, Pp 1-10 (2021)
The MRE11–RAD50–NBS1 (MRN) complex is critical for genomic stability. Although germline mutations in MRN may increase breast cancer susceptibility, such mutations are extremely rare. Here, we have conducted a comprehensive clinicopathological stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d46fd616f64211389df73d72b82667
Autor:
Louise E. Reynolds, John G. Gribben, Joseph G Taylor, Andrew Clear, Kairbaan Hodivala-Dilke, Tarek M. A. Abdel-Fatah, Louise Jones, Stephen Chan, Marina Roy-Luzarraga
Publikováno v:
JAMA Network Open
Key Points Question Are phosphorylated–focal adhesion kinase (pY397-FAK) expression levels in endothelial or tumor cells and tumor blood vessel density associated with response to chemotherapy and relapse-free survival after neoadjuvant chemotherap
Autor:
Andrew R. Green, Sunil R. Lakhani, Stephen Chan, Amy E. McCart Reed, Carlos Caldas, Graham Ball, Peter T. Simpson, Lynne Reid, Pulari U. Thangavelu, Alan Graham Pockley, Ian O. Ellis, Lorinc Pongor, Pascal H.G. Duijf, Jodi M. Saunus, Paul M. Moseley, Balazs Gyorffy, Tarek M. A. Abdel-Fatah
Publikováno v:
JAMA Network Open
Key Points Question Are sperm-associated antigen 5 (SPAG5) transcript or protein expressions associated with treatment response in patients with estrogen receptor–positive breast cancer? Findings In this cohort study including 12 720 patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f559b29c5f7150ecf35d27449fa1ede
https://hdl.handle.net/11541.2/34349
https://hdl.handle.net/11541.2/34349
Autor:
Andrew H S Lee, Jennifer Walker, Emad Rakhah, Graham Ball, Zsolt Hodi, Rebekah Webb, Arlene Chan, Tarek M. A. Abdel-Fatah, Ian O. Ellis, A. Graham Pockley, Matthew Griffiths, Jun Lim, Stephen Chan
Publikováno v:
Cancer Research. 80:P5-06
Background: NACT is a standard option for BC (T2-4, N0-3, M0) and certain BC phenotypes. The choice of AT based on the pre-NACT biomarkers status may not be optimum for individual patient because dynamic phenotypic changes induced by NACT may alter t
Autor:
Jun Lu, Tarek M. A. Abdel-Fatah, David P. Lane, Emad A. Rakha, Paul M. Moseley, Baiqu Huang, Mohammed A. Aleskandarany, Dong-Xu Liu, Suling Liu, Stephen Chan, Yan Li, Reuben James Broom, Runlin Z. Ma, Le-Ann Hwang, Christopher C. Nolan, Wen-Ming Cao, Jo K. Perry, Longxin Chen, Xiaojia Wang, Ian O. Ellis, Lili Li, Andrew R. Green, Peter E. Lobie
Publikováno v:
British Journal of Cancer
Background SHON nuclear expression (SHON-Nuc+) was previously reported to predict clinical outcomes to tamoxifen therapy in ERα+ breast cancer (BC). Herein we determined if SHON expression detected by specific monoclonal antibodies could provide a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a32024bfaf02e3fad9261f7433216d