Výsledky vyhledávání - "Tarek Khreiss"

Inhibition of K+ efflux prevents mitochondrial dysfunction, and suppresses caspase-3-, apoptosis-inducing factor-, and endonuclease G-mediated constitutive apoptosis in human neutrophils

Autor: Driss El Kebir, Levente Jozsef, Tarek Khreiss, János G. Filep

Publikováno v: Cellular Signalling. 18:2302-2313

Neutrophils die rapidly via apoptosis and their survival is contingent upon rescue from constitutive programmed cell death by signals from the microenvironment. In these experiments, we investigated whether prevention of K + efflux could affect the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d64171be4127c21233926b3b0749c63
https://doi.org/10.1016/j.cellsig.2006.05.013

Zobrazit plný text záznamu

Activation of TLR-9 Induces IL-8 Secretion through Peroxynitrite Signaling in Human Neutrophils

Autor: Driss El Kebir, Tarek Khreiss, János G. Filep, Levente Jozsef

Publikováno v: The Journal of Immunology. 176:1195-1202

Bacterial DNA containing unmethylated CpG motifs is emerging as an important regulator of functions of human neutrophil granulocytes (polymorphonuclear leukocytes (PMN)). These motifs are recognized by TLR-9. Recent studies indicate that peroxynitrit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba9f7757dea7650fd29ed3bce76da5b
https://doi.org/10.4049/jimmunol.176.2.1195

Zobrazit plný text záznamu

Opposing Effects of C-Reactive Protein Isoforms on Shear-Induced Neutrophil-Platelet Adhesion and Neutrophil Aggregation in Whole Blood

Autor: Tarek Khreiss, János G. Filep, Levente Jozsef, Lawrence A. Potempa

Publikováno v: Circulation. 110:2713-2720

Background—Plasma C-reactive protein (CRP) level is a powerful predictor of cardiovascular events. However, it is not known whether CRP could affect neutrophil-platelet adhesion and neutrophil aggregation, key events in acute coronary syndromes. Em

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90720a4b76965399d41f6d3bd941d07a
https://doi.org/10.1161/01.cir.0000146846.00816.dd

Zobrazit plný text záznamu

Activation of extracellular signal-regulated kinase couples platelet-activating factor-induced adhesion and delayed apoptosis of human neutrophils

Autor: John S.D. Chan, Tarek Khreiss, János G. Filep, Levente Jozsef

Publikováno v: Cellular Signalling. 16:801-810

Platelet-activating factor (PAF) promotes adhesion of neutrophil granulocytes to the endothelium, which is also linked to neutrophil survival. Here we report that PAF can prolong neutrophil survival by suppressing spontaneous apoptosis. PAF induced c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e889ecf78e10513ccb5ceb997323285
https://doi.org/10.1016/j.cellsig.2003.12.005

Zobrazit plný text záznamu

Conformational Rearrangement in C-Reactive Protein Is Required for Proinflammatory Actions on Human Endothelial Cells

Autor: Lawrence A. Potempa, János G. Filep, Levente Jozsef, Tarek Khreiss

Publikováno v: Circulation. 109:2016-2022

Background—C-reactive protein (CRP) has been suggested to actively amplify the inflammatory response underlying coronary heart diseases by directly activating endothelial cells. In this study, we investigated whether loss of the cyclic pentameric s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638084d6a193d59ec92e0d893de67c1f
https://doi.org/10.1161/01.cir.0000125527.41598.68

Zobrazit plný text záznamu

Extracellular signal-regulated kinase plays an essential role in endothelin-1-induced homotypic adhesion of human neutrophil granulocytes

Autor: János G. Filep, Alain Fournier, Levente Jozsef, Tarek Khreiss, John S.D. Chan

Publikováno v: British Journal of Pharmacology. 135:1167-1174

Endothelin-1 (ET-1) stimulates integrin-dependent adhesion of neutrophil granulocytes to endothelial cells, one of the early key events in acute inflammation. However, the signalling pathway(s) of ET-1-stimulated neutrophil adhesive responses has not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91ee43e610e9cbc2295cc07a11d192d0
https://doi.org/10.1038/sj.bjp.0704561

Zobrazit plný text záznamu

CpG motifs in bacterial DNA delay apoptosis of neutrophil granulocytes

Autor: Levente Jozsef, János G. Filep, Tarek Khreiss

Publikováno v: The FASEB Journal. 18:1776-1778

Human neutrophil granulocytes die rapidly, and their survival is contingent upon rescue from programmed cell death by signals from the environment. We now show that a novel signal for delaying neutrophil apoptosis is unmethylated CpG motifs prevalent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe5c042144d6bd308f8139e058386f5
https://doi.org/10.1096/fj.04-2048fje

Zobrazit plný text záznamu

Aspirin-triggered lipoxins override the apoptosis-delaying action of serum amyloid A in human neutrophils: a novel mechanism for resolution of inflammation

Autor: Driss El Kebir, János G. Filep, Charles N. Serhan, Nicos A. Petasis, Levente Jozsef, Wanling Pan, Tarek Khreiss

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 179(1)

Elevated plasma levels of the acute-phase reactant serum amyloid A (SAA) have been used as a marker and predictor of inflammatory diseases. SAA regulates leukocyte activation; however, it is not known whether it also modulates neutrophil apoptosis, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209dd3c2f643706b891122a4d9953800
https://pubmed.ncbi.nlm.nih.gov/17579083

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání