Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Tarek A Samad"'
Autor:
David von Schack, Michael J Agostino, B Stuart Murray, Yizheng Li, Padmalatha S Reddy, Jin Chen, Sung E Choe, Brian W Strassle, Christine Li, Brian Bates, Lynn Zhang, Huijuan Hu, Smita Kotnis, Brendan Bingham, Wei Liu, Garth T Whiteside, Tarek A Samad, Jeffrey D Kennedy, Seena K Ajit
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17670 (2011)
Neuropathic pain resulting from nerve lesions or dysfunction represents one of the most challenging neurological diseases to treat. A better understanding of the molecular mechanisms responsible for causing these maladaptive responses can help develo
Externí odkaz:
https://doaj.org/article/eb2ca94931af404d80273a0111199401
Autor:
Ryosuke Arakawa, Akihiro Takano, Sangram Nag, Zhisheng Jia, Nahid Amini, Kevin P. Maresca, Lei Zhang, Edmund J. Keliher, Christopher R. Butler, Justin R. Piro, Tarek A. Samad, Deborah Smith, Deane Nason, Steve O’Neil, Patrick Trapa, Kari R. Fonseca, John Litchfield, Timothy McCarthy, Richard E. Carson, Christer Halldin
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Background Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [11C]PF-06809247 into a
Externí odkaz:
https://doaj.org/article/0b2d2f0ac72047df80a3f5d00a8935c1
Autor:
Nora Rӧsch, Christian Barro, Zuzanna Michalak, Jens Kuhle, Carina Kaiser, Colin Mitchell, Aleksandra Maceski, Maria Pia Sormani, Jean Godin, Ludwig Kappos, David Leppert, Luke Chung, Alan Jacobs, Srinivas Shankara, Pascal Benkert, Evis Havari, Nadia Daizadeh, Tarek A Samad
Publikováno v:
Multiple Sclerosis Journal. 28:573-582
Background: Alemtuzumab efficacy and safety was demonstrated in CARE-MS I and extension studies (CAMMS03409; TOPAZ). Objective: Evaluate serum neurofilament light chain (sNfL) in CARE-MS I patients and highly active disease (HAD) subgroup, over 7 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344820f55c4a23065e16311d792d37cc
https://doi.org/10.1177/13524585211032348
https://doi.org/10.1177/13524585211032348
Autor:
Chad E. Beyer, Jason M. Dwyer, Michael J. Piesla, Brian J. Platt, Ru Shen, Zia Rahman, Karen Chan, Melissa T. Manners, Tarek A. Samad, Jeffrey D. Kennedy, Brendan Bingham, Garth T. Whiteside
Publikováno v:
Neurobiology of Disease, Vol 39, Iss 2, Pp 148-155 (2010)
Rimonabant was the first clinically marketed cannabinoid (CB)1 receptor antagonist developed to treat obesity. Unfortunately, CB1 receptor antagonism produced adverse psychiatric events in patients. To determine whether this occurs pre-clinically, we
Externí odkaz:
https://doaj.org/article/076a332ba28d4a31822f0239f65decee
Autor:
Akihiro Takano, Nahid Amini, Edmund J. Keliher, Christer Halldin, Lei Zhang, Richard E. Carson, Patrick Trapa, Sangram Nag, Ryosuke Arakawa, Deane M. Nason, Kevin P. Maresca, Zhisheng Jia, John Litchfield, Tarek A. Samad, Christopher Ryan Butler, Justin R. Piro, Timothy J. McCarthy, Deborah L. Smith, Steve O’Neil, Kari R. Fonseca
Background Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [11C]PF-06809247 into a clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b463c48140050426b0c96d37c2ff81
https://doi.org/10.21203/rs.3.rs-510615/v2
https://doi.org/10.21203/rs.3.rs-510615/v2
Autor:
Ryosuke, Arakawa, Akihiro, Takano, Sangram, Nag, Zhisheng, Jia, Nahid, Amini, Kevin P, Maresca, Lei, Zhang, Edmund J, Keliher, Christopher R, Butler, Justin R, Piro, Tarek A, Samad, Deborah, Smith, Deane, Nason, Steve, O'Neil, Patrick, Trapa, Kari R, Fonseca, John, Litchfield, Timothy, McCarthy, Richard E, Carson, Christer, Halldin
Publikováno v:
EJNMMI research. 12(1)
Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [Seven cynomolgus monkeys were enrolled for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a98c606e14bcd5e9f645c4b6b371c6bf
https://pubmed.ncbi.nlm.nih.gov/35244788
https://pubmed.ncbi.nlm.nih.gov/35244788
Autor:
Oskar Hansson, Michael W. Nagle, Julie Lee, Anders Mälarstig, Craig L. Hyde, Shorena Janelidze, Tarek A. Samad, Lori Fitz, Swetha Vijayaraghavan, Christopher D. Whelan, Erik Stomrud, Niklas Mattsson, Gayathri Ramaswamy, Richard A. Margolin
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-14 (2019)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
To date, the development of disease-modifying therapies for Alzheimer’s disease (AD) has largely focused on the removal of amyloid beta Aβ fragments from the CNS. Proteomic profiling of patient fluids may help identify novel therapeutic targets an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b833c2d9f5ae73ecc6317b1f6d0016
http://link.springer.com/article/10.1186/s40478-019-0795-2
http://link.springer.com/article/10.1186/s40478-019-0795-2
Autor:
Mostafa El-Negahy, Alaa Ahmed, Ahmed El-Adawy, Amr Mohamed, ElHewala, Tarek Abdel-Samad, Ali Hreik, Abdulla Milad
Publikováno v:
Zagazig University Medical Journal; 2022 Supplement, Vol. 28, p198-204, 7p
Autor:
Amr Mohamed El Adawy, Tarek Abdel Samad El Hewala, Omar Mohamed Abdel Wahab Kelany, Mohamed Adel Kamal Mohamed Abdeen
Publikováno v:
Zagazig University Medical Journal. 24:521-525
Background The goal of this study is to compare the results of long segment fixation versus short segment fixation with index level. Methods Fifty patients were enrolled in two groups twenty five patients each. First group was treated by long segment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7d3c91a8bbd8fe0092a4e70d6817731
https://doi.org/10.21608/zumj.2018.18294
https://doi.org/10.21608/zumj.2018.18294
Autor:
Matthieu Dumont, Maggie Roy, Pierre-Marc Jodoin, Felix C. Morency, Jean-Christophe Houde, Zhiyong Xie, Cici Bauer, Tarek A. Samad, Koene R. A. Van Dijk, James A. Goodman, Maxime Descoteaux, Alzheimer's Disease Neuroimaging Initiative
Publikováno v:
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience, Vol 11 (2019)
Frontiers in Aging Neuroscience, Vol 11 (2019)
Recent evidence show that neuroinflammation plays a role in many neurological diseases including mild cognitive impairment (MCI) and Alzheimer’s disease (AD), and that free water (FW) modeling from clinically acquired diffusion MRI (DTI-like acquis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39297d5f437d7170a1f9c2fb9caf135
https://doi.org/10.3389/fnagi.2019.00270
https://doi.org/10.3389/fnagi.2019.00270