Caractérisation du trafic cellulaire du canal potassique à deux domaines P UNC-58 par la protéine UNC-44 chez le nématode C. elegans

Autor: Tardy, Philippe

Les canaux potassiques à deux domaines P (K2P) contrôlent l’excitabilité cellulaire et jouent un rôle central dans l’établissement et le maintien du potentiel de repos membranaire dans la majorité des cellules animales. Depuis leur identifi

Externí odkaz: http://www.theses.fr/2018LYSE1157

A 3D model for annular displacements of wellbore completion fluids with casing movement

Autor: Tardy, Philippe M.J.

Publikováno v: In Journal of Petroleum Science and Engineering March 2018 162:114-136

Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels

Autor: Ben Soussia, Ismail, El Mouridi, Sonia, Kang, Dawon, Leclercq-Blondel, Alice, Khoubza, Lamyaa, Tardy, Philippe, Zariohi, Nora, Gendrel, Marie, Lesage, Florian, Kim, Eun-Jin, Bichet, Delphine, Andrini, Olga, Boulin, Thomas

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.787. ⟨10.1038/s41467-019-08710-3⟩
Nature Communications, 2019, 10 (1), pp.787. ⟨10.1038/s41467-019-08710-3⟩

Mutations that modulate the activity of ion channels are essential tools to understand the biophysical determinants that control their gating. Here, we reveal the conserved role played by a single amino acid position (TM2.6) located in the second tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::266c41ef1141a4166596211af053f14e
https://doaj.org/article/89358a70ca0b4f15867e6e9b7f65b48a

Reliable CRISPR/Cas9 Genome Engineering in Caenorhabditis elegans Using a Single Efficient sgRNA and an Easily Recognizable Phenotype

Autor: El Mouridi, Sonia, Lecroisey, Claire, Tardy, Philippe, Mercier, Marine, Leclercq-Blondel, Alice, Zariohi, Nora, Boulin, Thomas

Publikováno v: G3: Genes|Genomes|Genetics
G3
G3, 2017, 7 (5), pp.1429-1437. ⟨10.1534/g3.117.040824⟩
G3, Genetics Society of America, 2017, 7 (5), pp.1429-1437. ⟨10.1534/g3.117.040824⟩
G3: Genes, Genomes, Genetics, Vol 7, Iss 5, Pp 1429-1437 (2017)

International audience; CRISPR/Cas9 genome engineering strategies allow the directed modification of the Caenorhabditis elegans genome to introduce point mutations, generate knock-out mutants, and insert coding sequences for epitope or fluorescent ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::73e89a9a6ac8a52d2bc1facc7385c750
http://europepmc.org/articles/PMC5427500

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