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Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma

Autor: Corre, Sébastien, Tardif, Nina, Mouchet, Nicolas, Leclair, Héloïse M., Boussemart, Lise, Gautron, Arthur, Bachelot, Laura, Perrot, Anthony, Soshilov, Anatoly, Rogiers, Aljosja, Rambow, Florian, Dumontet, Erwan, Tarte, Karin, Bessede, Alban, Guillemin, Gilles J., Marine, Jean-Christophe, Denison, Michael S., Gilot, David, Galibert, Marie-Dominique

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications, 2018, 9 (1), pp.4775. ⟨10.1038/s41467-018-06951-2⟩
Corre, S; Tardif, N; Mouchet, N; Leclair, HM; Boussemart, L; Gautron, A; et al.(2018). Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma. Nature Communications, 9(1), 4775. doi: 10.1038/s41467-018-06951-2. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/1jf4j4r5
Nature communications, vol 9, iss 1
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.4775. ⟨10.1038/s41467-018-06951-2⟩

BRAF inhibitors target the BRAF-V600E/K mutated kinase, the driver mutation found in 50% of cutaneous melanoma. They give unprecedented anti-tumor responses but acquisition of resistance ultimately limits their clinical benefit. The master regulators

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d5841be9aefb4fd97a9496ed11115dc8
http://link.springer.com/article/10.1038/s41467-018-06951-2

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