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The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab.

Autor: Gasser P; Department of BioMedical Research, University of Bern, Bern, Switzerland.; Department of Rheumatology, Immunology and Allergology, University Hospital Bern, Bern, Switzerland.; Graduate School of Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland., Tarchevskaya SS; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA., Guntern P; Department of BioMedical Research, University of Bern, Bern, Switzerland.; Department of Rheumatology, Immunology and Allergology, University Hospital Bern, Bern, Switzerland.; Graduate School of Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland., Brigger D; Department of BioMedical Research, University of Bern, Bern, Switzerland.; Department of Rheumatology, Immunology and Allergology, University Hospital Bern, Bern, Switzerland., Ruppli R; Department of BioMedical Research, University of Bern, Bern, Switzerland.; Department of Rheumatology, Immunology and Allergology, University Hospital Bern, Bern, Switzerland., Zbären N; Department of BioMedical Research, University of Bern, Bern, Switzerland.; Department of Rheumatology, Immunology and Allergology, University Hospital Bern, Bern, Switzerland., Kleinboelting S; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA., Heusser C; Pharmaceutical Research, Novartis AG, 4002, Basel, Switzerland., Jardetzky TS; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA. tjardetzky@stanford.edu., Eggel A; Department of BioMedical Research, University of Bern, Bern, Switzerland. alexander.eggel@dbmr.unibe.ch.; Department of Rheumatology, Immunology and Allergology, University Hospital Bern, Bern, Switzerland. alexander.eggel@dbmr.unibe.ch.

Publikováno v: Nature communications [Nat Commun] 2020 Jan 08; Vol. 11 (1), pp. 165. Date of Electronic Publication: 2020 Jan 08.

Accelerated disassembly of IgE-receptor complexes by a disruptive macromolecular inhibitor.

Autor: Kim B; Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA., Eggel A, Tarchevskaya SS, Vogel M, Prinz H, Jardetzky TS

Publikováno v: Nature [Nature] 2012 Nov 22; Vol. 491 (7425), pp. 613-7. Date of Electronic Publication: 2012 Oct 28.

Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha.

Autor: Garman SC; Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA., Wurzburg BA, Tarchevskaya SS, Kinet JP, Jardetzky TS

Publikováno v: Nature [Nature] 2000 Jul 20; Vol. 406 (6793), pp. 259-66.