Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Taras, Valovka"'
Autor:
Ilja Vietor, Domagoj Cikes, Kati Piironen, Theodora Vasakou, David Heimdörfer, Ronald Gstir, Matthias David Erlacher, Ivan Tancevski, Philipp Eller, Egon Demetz, Michael W Hess, Volker Kuhn, Gerald Degenhart, Jan Rozman, Martin Klingenspor, Martin Hrabe de Angelis, Taras Valovka, Lukas A Huber
Publikováno v:
eLife, Vol 12 (2023)
Delta-like homolog 1 (Dlk1), an inhibitor of adipogenesis, controls the cell fate of adipocyte progenitors. Experimental data presented here identify two independent regulatory mechanisms, transcriptional and translational, by which Ifrd1 (TIS7) and
Externí odkaz:
https://doaj.org/article/fa4d5e5f892d4d6f9b842a1710b1e52a
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The nuclear factor kappa B (NF-κB) family of dimeric transcription factors regulates a wide range of genes by binding to their specific DNA regulatory sequences. NF-κB is an important therapeutic target linked to a number of cancers as wel
Externí odkaz:
https://doaj.org/article/d7d7351fa7fa4902828aa877384f06ac
Autor:
Rémi Duclaux-Loras, Corinne Lebreton, Jérémy Berthelet, Fabienne Charbit-Henrion, Ophelie Nicolle, Céline Revenu de Courtils, Stephanie Waich, Taras Valovka, Anis Khiat, Marion Rabant, Caroline Racine, Ida Chiara Guerrera, Júlia Baptista, Maxime M. Mahe, Michael W. Hess, Béatrice Durel, Nathalie Lefort, Céline Banal, Mélanie Parisot, Cecile Talbotec, Florence Lacaille, Emmanuelle Ecochard-Dugelay, Arzu Meltem Demir, Georg F. Vogel, Laurence Faivre, Astor Rodrigues, Darren Fowler, Andreas R. Janecke, Thomas Müller, Lukas A. Huber, Fernando Rodrigues-Lima, Frank M. Ruemmele, Holm H. Uhlig, Filippo Del Bene, Grégoire Michaux, Nadine Cerf-Bensussan, Marianna Parlato
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Variants in the UNC45A cochaperone have been recently associated with a syndrome combining diarrhea, cholestasis, deafness, and bone fragility. Yet the mechanism underlying intestinal failure in UNC45A deficiency remains unclear. Here, biallelic vari
Externí odkaz:
https://doaj.org/article/6503ecabc11443e384dfca9f5f76d443
Autor:
Edda Haberlandt, Taras Valovka, Tanja Janjic, Thomas Müller, Georgios Blatsios, Daniela Karall, Andreas R. Janecke
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 9, Iss 3, Pp n/a-n/a (2021)
Abstract Background The epileptic encephalopathies display extensive locus and allelic heterogeneity. Biallelic truncating DOCK7 variants were recently reported in five children with early‐onset epilepsy, intellectual disability, and cortical blind
Externí odkaz:
https://doaj.org/article/7bd40df55dd6455398cd4c6b13bd02b3
Autor:
Peter D. Leitner, Thomas Jakschitz, Ronald Gstir, Stefan Stuppner, Sebastian Perkams, Maren Kruus, Alexander Trockenbacher, Christoph Griesbeck, Günther K. Bonn, Lukas A. Huber, Taras Valovka
Publikováno v:
Cells, Vol 11, Iss 9, p 1407 (2022)
Inflammatory skin diseases, including atopic dermatitis (AD) and psoriasis, are increasing in populations worldwide. The treatment of patients with AD and other forms of skin inflammation is mainly based on the use of topical corticosteroids or calci
Externí odkaz:
https://doaj.org/article/44fc41fe2bae4f339ad3dbdf76cd2a5c
CR4 Signaling Contributes to a DC-Driven Enhanced Immune Response Against Complement-Opsonized HIV-1
Autor:
Marta Bermejo-Jambrina, Michael Blatzer, Paula Jauregui-Onieva, Teodor E. Yordanov, Paul Hörtnagl, Taras Valovka, Lukas A. Huber, Doris Wilflingseder, Wilfried Posch
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Dendritic cells (DCs) possess intrinsic cellular defense mechanisms to specifically inhibit HIV-1 replication. In turn, HIV-1 has evolved strategies to evade innate immune sensing by DCs resulting in suboptimal maturation and poor antiviral immune re
Externí odkaz:
https://doaj.org/article/e5e2ae5d2cb3474293c79d483a1f2c7d
Autor:
Barbara Hausott, Jong-Whi Park, Taras Valovka, Martin Offterdinger, Michael W. Hess, Stephan Geley, Lars Klimaschewski
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Sprouty proteins act ubiquitously as signaling integrators and inhibitors of receptor tyrosine kinase (RTK) activated pathways. Among the four Sprouty isoforms, Sprouty2 is a key regulator of growth factor signaling in several neurological disorders.
Externí odkaz:
https://doaj.org/article/b7eb4f8c82ef4f0c8baec415553ed240
Autor:
Michael O. Hottiger, Max Gassmann, Stephan Keller, Taras Valovka, Simon Messner, Suheda Erener, Paul O. Hassa, Lubor Borsig, Michael Elser
Hypoxia-inducible factor 1 (HIF-1) is the key transcription factor regulating hypoxia-dependent gene expression. Lack of oxygen stabilizes HIF-1, which in turn modulates the gene expression pattern to adapt cells to the hypoxic environment. Activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec2b7ad7081efb235317ab87839a86c
https://doi.org/10.1158/1541-7786.c.6542742
https://doi.org/10.1158/1541-7786.c.6542742
Autor:
Michael O. Hottiger, Max Gassmann, Stephan Keller, Taras Valovka, Simon Messner, Suheda Erener, Paul O. Hassa, Lubor Borsig, Michael Elser
Supplementary Figure S1 from Poly(ADP-Ribose) Polymerase 1 Promotes Tumor Cell Survival by Coactivating Hypoxia-Inducible Factor-1–Dependent Gene Expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d5dbcc2f624ebfa4073369a29c0672
https://doi.org/10.1158/1541-7786.22520718
https://doi.org/10.1158/1541-7786.22520718
Publikováno v:
Biology Open, Vol 3, Iss 5, Pp 397-407 (2014)
The myc protooncogene encodes the Myc transcription factor which is the essential part of the Myc–Max network controlling fundamental cellular processes. Deregulation of myc leads to tumorigenesis and is a hallmark of many human cancers. We have re
Externí odkaz:
https://doaj.org/article/7924d665f39c4079b43583cef953f385