Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation.

Autor: Sinatra L; Institute for Drug Discovery, Medical Faculty, Leipzig University, Brüderstraße 34, 04103 Leipzig, Germany., Vogelmann A; Institute of Pharmaceutical Sciences, University of Freiburg, Albertstraße 25, 79104 Freiburg, Germany., Friedrich F; Institute of Pharmaceutical Sciences, University of Freiburg, Albertstraße 25, 79104 Freiburg, Germany., Tararina MA; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States., Neuwirt E; Institute of Neuropathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacherstraße 64, 79106 Freiburg, Germany.; CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Schänzlestraße 18, 79104 Freiburg, Germany., Colcerasa A; Institute of Pharmaceutical Sciences, University of Freiburg, Albertstraße 25, 79104 Freiburg, Germany., König P; Department of Pharmaceutical & Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany., Toy L; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-University Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, 91058 Erlangen, Germany., Yesiloglu TZ; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, Wolfgang-Langenbeck-Straße 2-4, 06120 Halle (Saale), Germany., Hilscher S; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, Wolfgang-Langenbeck-Straße 2-4, 06120 Halle (Saale), Germany.; Department of Enzymology, Charles Tanford Protein Center, Institute of Biochemistry and Biotechnology, Martin-Luther-University Halle-Wittenberg, 06120 Halle, Germany., Gaitzsch L; Institute of Pharmaceutical Sciences, University of Freiburg, Albertstraße 25, 79104 Freiburg, Germany., Papenkordt N; Institute of Pharmaceutical Sciences, University of Freiburg, Albertstraße 25, 79104 Freiburg, Germany., Zhai S; Department of Pharmaceutical & Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany., Zhang L; Institute of Biochemistry, University of Freiburg, Albertstraße 21, 79104 Freiburg, Germany., Romier C; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, CNRS UMR 7104, Inserm UMR-S 1258, 1 rue Laurent Fries, F-67400 Illkirch, France., Einsle O; Institute of Biochemistry, University of Freiburg, Albertstraße 21, 79104 Freiburg, Germany., Sippl W; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, Wolfgang-Langenbeck-Straße 2-4, 06120 Halle (Saale), Germany., Schutkowski M; Department of Enzymology, Charles Tanford Protein Center, Institute of Biochemistry and Biotechnology, Martin-Luther-University Halle-Wittenberg, 06120 Halle, Germany., Gross O; Institute of Neuropathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacherstraße 64, 79106 Freiburg, Germany.; CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Schänzlestraße 18, 79104 Freiburg, Germany.; Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine, University of Freiburg, Breisacherstraße 64, 79106 Freiburg, Germany., Bendas G; Department of Pharmaceutical & Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany., Christianson DW; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States., Hansen FK; Institute for Drug Discovery, Medical Faculty, Leipzig University, Brüderstraße 34, 04103 Leipzig, Germany.; Department of Pharmaceutical & Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany., Jung M; Institute of Pharmaceutical Sciences, University of Freiburg, Albertstraße 25, 79104 Freiburg, Germany., Schiedel M; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-University Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, 91058 Erlangen, Germany.; Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Nov 09; Vol. 66 (21), pp. 14787-14814. Date of Electronic Publication: 2023 Oct 30.

Structure of the Repurposed Fungal Terpene Cyclase FlvF Implicated in the C-N Bond-Forming Reaction of Flavunoidine Biosynthesis.

Autor: Tararina MA; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States., Yee DA; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095-1405, United States., Tang Y; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095-1405, United States.; Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1405, United States., Christianson DW; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States.

Publikováno v: Biochemistry [Biochemistry] 2022 Sep 20; Vol. 61 (18), pp. 2014-2024. Date of Electronic Publication: 2022 Aug 29.

Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A.

Autor: Lin L, Olson ME, Sugane T, Turner LD, Tararina MA; Program in Biomolecular Pharmacology, Boston University School of Medicine, Boston, Massachusetts 02118, United States., Nielsen AL, Kurbanov EK; Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States., Pellett S; Department of Bacteriology, University of Wisconsin, 1550 Linden Drive, Madison, Wisconsin 53706, United States., Johnson EA; Department of Bacteriology, University of Wisconsin, 1550 Linden Drive, Madison, Wisconsin 53706, United States., Cohen SM; Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States., Allen KN; Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States., Janda KD

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Oct 08; Vol. 63 (19), pp. 11100-11120. Date of Electronic Publication: 2020 Sep 18.

Crystallography Coupled with Kinetic Analysis Provides Mechanistic Underpinnings of a Nicotine-Degrading Enzyme.

Autor: Tararina MA; Program in Biomolecular Pharmacology , Boston University School of Medicine , 72 East Concord Street , Boston , Massachusetts 02118 , United States., Xue S, Smith LC, Muellers SN; Department of Chemistry , Boston University , 590 Commonwealth Avenue , Boston , Massachusetts 02215 , United States., Miranda PO, Janda KD, Allen KN; Program in Biomolecular Pharmacology , Boston University School of Medicine , 72 East Concord Street , Boston , Massachusetts 02118 , United States.; Department of Chemistry , Boston University , 590 Commonwealth Avenue , Boston , Massachusetts 02215 , United States.

Publikováno v: Biochemistry [Biochemistry] 2018 Jul 03; Vol. 57 (26), pp. 3741-3751. Date of Electronic Publication: 2018 Jun 13.