Systematic multi-trait AAV capsid engineering for efficient gene delivery

Autor: Fatma-Elzahraa Eid, Albert T. Chen, Ken Y. Chan, Qin Huang, Qingxia Zheng, Isabelle G. Tobey, Simon Pacouret, Pamela P. Brauer, Casey Keyes, Megan Powell, Jencilin Johnston, Binhui Zhao, Kasper Lage, Alice F. Tarantal, Yujia A. Chan, Benjamin E. Deverman

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Broadening gene therapy applications requires manufacturable vectors that efficiently transduce target cells in humans and preclinical models. Conventional selections of adeno-associated virus (AAV) capsid libraries are inefficient at search

Externí odkaz: https://doaj.org/article/63fea91c4ddf435fb80d6986bfc4dbae

Correlation of antigen expression with epigenetic modifications after rAAV delivery of a human factor IX variant in mice and rhesus macaques

Autor: Pekrun, Katja, Stephens, Calvin J., Gonzalez-Sandoval, Adriana, Goswami, Aranyak, Zhang, Feijie, Tarantal, Alice F., Blouse, Grant, Kay, Mark A.

Publikováno v: In Molecular Therapy 3 July 2024 32(7):2064-2079

Lipid nanoparticle-mediated mRNA delivery to CD34 ⁺ cells in rhesus monkeys.

Autor: Kim H; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA., Zenhausern R; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA., Gentry K; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA., Lian L; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA., Huayamares SG; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA., Radmand A; Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA.; Department of Chemical Engineering, Georgia Institute of Technology, Atlanta, GA, USA., Loughrey D; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA., Podilapu AR; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA., Hatit MZC; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA., Ni H; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA., Li A; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA., Shajii A; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA., Peck HE; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA., Han K; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA., Hua X; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA., Jia S; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA., Martinez M; California National Primate Research Center, University of California, Davis, Davis, CA, USA., Lee C; California National Primate Research Center, University of California, Davis, Davis, CA, USA.; Department of Pediatrics, University of California, Davis, Davis, CA, USA., Santangelo PJ; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA., Tarantal A; California National Primate Research Center, University of California, Davis, Davis, CA, USA.; Department of Pediatrics, University of California, Davis, Davis, CA, USA.; Department of Cell Biology and Human Anatomy, University of California, Davis, Davis, CA, USA., Dahlman JE; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA. james.dahlman@emory.edu.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2024 Nov 22. Date of Electronic Publication: 2024 Nov 22.

Die rol van tegnologiekoördineerders in inligting– en kommunikasie tegnologie [kommunikasietegnologie] in Suid–Afrikaanse skole / Tarantal J.C.

Autor: Tarantal, Jacobus Cornelius

Inligting en kommunikasietegnologie (IKT) vorm ‘n belangrike komponent van effektiewe onderrig en leer. Ten spyte van die gedokumenteerde voordele wat IKT vir onderrig en leer inhou, bly IKT–integrering in skole steeds gebrekkig. Die implementeri

Externí odkaz: http://hdl.handle.net/10394/7574

Rapid molecular imaging of active thrombi in vivo using aptamer-antidote probes

Autor: Gray, Bethany Powell, Kelly, Linsley, Steen-Burrell, Kady-Ann, Layzer, Juliana M., Rempel, Rachel E., Nimjee, Shahid M., Cooley, Brian C., Tarantal, Alice F., Sullenger, Bruce A.

Publikováno v: In Molecular Therapy - Nucleic Acids 14 March 2023 31:440-451