Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Taraneh Zarin"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010238 (2022)
A major challenge to the characterization of intrinsically disordered regions (IDRs), which are widespread in the proteome, but relatively poorly understood, is the identification of molecular features that mediate functions of these regions, such as
Externí odkaz:
https://doaj.org/article/cb97a63ed41d4fd2a040177bf0b5297a
Publikováno v:
eLife, Vol 10 (2021)
In previous work, we showed that intrinsically disordered regions (IDRs) of proteins contain sequence-distributed molecular features that are conserved over evolution, despite little sequence similarity that can be detected in alignments (Zarin et al
Externí odkaz:
https://doaj.org/article/a6e4dce7bd0e4410a47cefd1282bcbdc
Publikováno v:
eLife, Vol 8 (2019)
Intrinsically disordered regions make up a large part of the proteome, but the sequence-to-function relationship in these regions is poorly understood, in part because the primary amino acid sequences of these regions are poorly conserved in alignmen
Externí odkaz:
https://doaj.org/article/1ef704afc0bf411db20f5fbcef6b58fb
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006735 (2017)
Regulatory networks often increase in complexity during evolution through gene duplication and divergence of component proteins. Two models that explain this increase in complexity are: 1) adaptive changes after gene duplication, such as resolution o
Externí odkaz:
https://doaj.org/article/f0ef18ca1ff94da990049a0607b78b52
Autor:
Nadia Sachewsky, Jessica Hunt, Michael J. Cooke, Ashkan Azimi, Taraneh Zarin, Carween Miu, Molly S. Shoichet, Cindi M. Morshead
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 8, Pp 953-961 (2014)
Cyclosporin A (CsA) has direct effects on neural stem and progenitor cells (together termed neural precursor cells; NPCs) in the adult central nervous system. Administration of CsA in vitro or in vivo promotes the survival of NPCs and expands the poo
Externí odkaz:
https://doaj.org/article/8b890c3c17724be7916a1e8d4033a2e2
A major challenge to the characterization of intrinsically disordered regions (IDRs), which are widespread in the proteome, but relatively poorly understood, is the identification of molecular features that mediate functions of these regions, such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6566ffa05809bacf6bb9a0e93c4cfb3e
https://doi.org/10.1101/2021.07.29.454330
https://doi.org/10.1101/2021.07.29.454330
Publikováno v:
Biochemical Society transactions. 48(5)
What do we know about the molecular evolution of functional protein condensation? The capacity of proteins to form biomolecular condensates (compact, protein-rich states, not bound by membranes, but still separated from the rest of the contents of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6374a71fea12d282fc9f464f2626dbcf
https://pubmed.ncbi.nlm.nih.gov/32985656
https://pubmed.ncbi.nlm.nih.gov/32985656
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Previously, we showed that intrinsically disordered regions in proteins (IDRs) contain multiple sequence-distributed molecular features that are conserved over evolution, despite little sequence similarity that can be detected in alignments (Zarin et
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2e62dcc6f8db7d5f41d420181e1def
https://doi.org/10.1101/2020.06.23.167361
https://doi.org/10.1101/2020.06.23.167361