Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Taraneh Mirzadegan"'
Autor:
Scott D. Bembenek, Hariharan Venkatesan, Hillary M. Peltier, Mark D. Rosen, Terrance D. Barrett, Kimon C. Kanelakis, Heather L. Palomino, Theresa I. Brondstetter, Taraneh Mirzadegan, Michael H. Rabinowitz
Publikováno v:
ACS Omega, Vol 4, Iss 4, Pp 6703-6708 (2019)
Externí odkaz:
https://doaj.org/article/2f7bcabc827d4448a44a96c74939a085
Autor:
Kelly L. Damm-Ganamet, Alan D. Wickenden, Taraneh Mirzadegan, Marie-Laure Rives, Heather M. McAllister
Publikováno v:
J Biol Chem
Excitatory amino acid transporters (EAATs) represent a protein family that is an emerging drug target with great therapeutic potential for managing central nervous system disorders characterized by dysregulation of glutamatergic neurotransmission. As
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d110c0bb332f0e5ce669aeea4b3a2edf
https://doi.org/10.1074/jbc.ac119.011190
https://doi.org/10.1074/jbc.ac119.011190
Autor:
Renee L. DesJarlais, Tami Marrone, Jamie M. Schiffer, Amy Y. Shih, Taraneh Mirzadegan, Kelly L. Damm-Ganamet, Laura Pérez-Benito
Publikováno v:
Journal of Medicinal Chemistry. 63:1929-1936
The topic of gender equality within the United States workforce is receiving a great deal of attention. The field of chemistry is no exception and is increasingly focused on taking steps to achieve gender diversity within the chemistry workforce. Ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::714622272a902f3d98fc482c6a5dad2e
https://doi.org/10.1021/acs.jmedchem.9b01512
https://doi.org/10.1021/acs.jmedchem.9b01512
Autor:
Eduardo V. Mercado-Marin, Jim Na, Renee L. DesJarlais, Helena C. Steffens, Genesis M. Bacani, Mark Seierstad, De Michael Chung, Taraneh Mirzadegan, Mark S. Tichenor
Publikováno v:
ACS Med Chem Lett
[Image: see text] Drug discovery building blocks available commercially or within an internal inventory cover a diverse range of chemical space and yet describe only a tiny fraction of all chemically feasible reagents. Vendors will eagerly provide to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e8eae69e6bffcbc5c1849a0bd619e3
https://europepmc.org/articles/PMC8591720/
https://europepmc.org/articles/PMC8591720/
Publikováno v:
Journal of chemical information and modeling. 60(11)
Relative free energy perturbation (FEP) methods have become increasingly popular within the pharmaceutical industry; however, despite time constraints within drug discovery cycles, caution should be applied in the deployment of such methods as protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4af670c566f4bfccfe34f48609e9c56
https://pubmed.ncbi.nlm.nih.gov/32786514
https://pubmed.ncbi.nlm.nih.gov/32786514
Autor:
Kelly L, Damm-Ganamet, Renee L, DesJarlais, Tami, Marrone, Amy Y, Shih, Jamie M, Schiffer, Laura, Perez-Benito, Taraneh, Mirzadegan
Publikováno v:
Journal of medicinal chemistry. 63(5)
The topic of gender equality within the United States workforce is receiving a great deal of attention. The field of chemistry is no exception and is increasingly focused on taking steps to achieve gender diversity within the chemistry workforce. Ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba5fad6079a446aa32eea26fe7bfe24c
https://pubmed.ncbi.nlm.nih.gov/31913036
https://pubmed.ncbi.nlm.nih.gov/31913036
Publikováno v:
Biophysical Journal. 114:32-39
The stimulator-of-interferon-genes (STING) protein is involved in innate immunity. It has recently been shown that modulation of STING can lead to an aggressive antitumor response. DMXAA is an antitumor agent that had shown great promise in murine mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d599e08c8cefcabe54ca0736416317f2
https://doi.org/10.1016/j.bpj.2017.10.027
https://doi.org/10.1016/j.bpj.2017.10.027
Autor:
Taraneh Mirzadegan, Navin Rao, Alec D. Lebsack, Kelly L. Damm-Ganamet, Nidhi Arora, John J. M. Wiener, James P. Edwards, Stéphane Bécart, Lori Westover, Marina I. Nelen, Heather M. McAllister
Publikováno v:
Journal of chemical information and modeling. 59(5)
At the onset of a drug discovery program, the goal is to identify novel compounds with appropriate chemical features that can be taken forward as lead series. Here, we describe three prospective case studies, Bruton Tyrosine Kinase (BTK), RAR-Related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbade40c3c722e76c4ce85a5dd9e29c6
https://pubmed.ncbi.nlm.nih.gov/30817167
https://pubmed.ncbi.nlm.nih.gov/30817167
Autor:
Arjun Saha, Annie X. Liu, Samantha J Allen, Teena M Varghese, Michael D. Hack, Taraneh Mirzadegan
Publikováno v:
Journal of chemical information and modeling. 58(10)
Since many projects at pharmaceutical organizations get their start from a high-throughput screening (HTS) campaign, improving the quality of the HTS deck can improve the likelihood of discovering a high-quality lead molecule that can be progressed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3005dae336d7eccd61e7169f0cce2531
https://pubmed.ncbi.nlm.nih.gov/30204440
https://pubmed.ncbi.nlm.nih.gov/30204440
Determination of a Focused Mini Kinase Panel for Early Identification of Selective Kinase Inhibitors
Publikováno v:
Journal of chemical information and modeling. 58(7)
We analyzed an extensive data set of 3000 Janssen kinase inhibitors (spanning some 40 therapeutic projects) profiled at 414 kinases in the DiscoverX KINOME scan to better understand the necessity of using such a full kinase panel versus simply profil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038723eb4d773fcc27cc4adb9e6d4a50
https://pubmed.ncbi.nlm.nih.gov/29792797
https://pubmed.ncbi.nlm.nih.gov/29792797