Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tarana, Umar"'
Publikováno v:
Chemical Biology & Drug Design. 100:674-681
Alzheimer's disease (AD) is one of the prominent causes for disability and lowered quality of life worldwide in elderly population. It has fostered immense burden to AD patients, families and society. Burgeoning progress in the field of pathogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a1d3c192f7e1cb485e192ac0af906c
https://doi.org/10.1111/cbdd.14133
https://doi.org/10.1111/cbdd.14133
Publikováno v:
ChemistrySelect. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaecfe3ebfdb1be4b52e417a282c48e0
https://doi.org/10.1002/slct.202204960
https://doi.org/10.1002/slct.202204960
Autor:
Jitendra Kumar, Shruti Shalini, Kausar Raza, Prerna Seth, Manisha Tiwari, Siddharth Gusain, Nasimul Hoda, Tarana Umar
Publikováno v:
European Journal of Medicinal Chemistry. 175:2-19
2-(piperazin-1-yl) N-(1H-pyrazolo[3,4-b]pyridin-3-yl)acetamides are described as a new class of selective and potent acetylcholinesterase (AChE) inhibitors and amyloid β aggregation inhibitors. Formation of synthesized compounds (P1 P9) was justifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a012ef13a42ef0263fb50d12376f5b8c
https://doi.org/10.1016/j.ejmech.2019.04.038
https://doi.org/10.1016/j.ejmech.2019.04.038
Autor:
Shruti Shalini, Manisha Tiwari, Waqar Ahmed, Jitendra Kumar, Kausar Raza, Nasimul Hoda, Tarana Umar, Siddharth Gusain
Publikováno v:
MedChemComm. 9:1891-1904
In the journey towards the development of potent multi-targeted ligands for the treatment of Alzheimer's disease, a series of Aβ aggregation inhibitors having quinoline scaffold were designed utilizing computational biology tools, synthesized and ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4452d8dc557dbd4dca70d1646750ea4a
https://doi.org/10.1039/c8md00312b
https://doi.org/10.1039/c8md00312b
Naphthalene-triazolopyrimidine hybrid compounds as potential multifunctional anti-Alzheimer's agents
Autor:
Kausar Raza, Nasimul Hoda, Manisha Tiwari, Siddharth Gusain, Jitendra Kumar, Tarana Umar, Shruti Shalini
Publikováno v:
Bioorganicmedicinal chemistry. 27(14)
In an attempt to construct potential anti-Alzheimer’s agents Naphthalene-triazolopyrimidine hybrids were synthesized and screened in vitro against the two cholinesterases (ChE)s, amyloid β aggregation and for antioxidation activity. Single-crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040c3de51552adcc6a93d7b19a034cb6
https://pubmed.ncbi.nlm.nih.gov/31176571
https://pubmed.ncbi.nlm.nih.gov/31176571
Autor:
Tarana, Umar, Shruti, Shalini, Md Kausar, Raza, Siddharth, Gusain, Jitendra, Kumar, Waqar, Ahmed, Manisha, Tiwari, Nasimul, Hoda
Publikováno v:
MedChemComm. 9(11)
In the journey towards the development of potent multi-targeted ligands for the treatment of Alzheimer's disease, a series of Aβ aggregation inhibitors having quinoline scaffold were designed utilizing computational biology tools, synthesized and ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8bae7577efe42dab5fbb6e0eddf0987d
https://pubmed.ncbi.nlm.nih.gov/30568757
https://pubmed.ncbi.nlm.nih.gov/30568757
Autor:
Nasimul Hoda, Tarana Umar
Publikováno v:
MedChemComm. 6:2063-2080
Neurodegenerative disease appears as a result of genomic lesions which lead to alterations at multiple levels like genomic product and biological pathways. It involves destruction of existing neuroprotective mechanisms inside body which initiates the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07e8375673bb3c54a5b97c06b1626b50
https://doi.org/10.1039/c5md00419e
https://doi.org/10.1039/c5md00419e
Autor:
Nasimul Hoda, Tarana Umar
Publikováno v:
Current topics in medicinal chemistry. 17(31)
Alzheimer's Disease (AD) is a fatal neurodegenerative disorder, having a complex aetiology with numerous possible drug targets. There are targets that have been known for years while more new targets and theories have also emerged. Beta amyloid and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0c86b3c1e79e18c085a0ff3c709a16
https://pubmed.ncbi.nlm.nih.gov/29332579
https://pubmed.ncbi.nlm.nih.gov/29332579
Autor:
Mohammad Mobashir, Tasneem Kausar, Nasimul Hoda, Shahid M. Nayeem, Tarana Umar, Jitendra Kumar
Publikováno v:
Journal of molecular modeling. 23(1)
The phosphodiesterase (PDE) family of proteins are important regulators of signal transduction, which they achieve by controlling the secondary messengers cyclic AMP (cAMP) and cyclic GMP (cGMP). cAMP and cGMP are involved in many critical intracellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dfa99f16e5297d921449bc85417921b
https://pubmed.ncbi.nlm.nih.gov/27966018
https://pubmed.ncbi.nlm.nih.gov/27966018